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2
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0025254559
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Transduction of Receptor Signal into Modulation of Effector Activity by G Proteins: the First 20 Years or so...
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(1990)
FASEB J
, vol.4
, pp. 3178-3188
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Birnbaumer1
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3
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0027232606
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Molecular and Functional Diversity of Mammalian GS stimulated Adenylyl Cyclases
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in press
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(1993)
FASEB J
, vol.7
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Iyengar1
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6
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0025663760
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Identification of a Specialized Adenylyl Cyclase that May Mediate Odorant Detection
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(1990)
Science
, vol.250
, pp. 1403-1406
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-
Bakalyar1
Reed2
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8
-
-
0026680815
-
Isolation and Characterization of a Novel Cardiac Adenylyl Cyclase cDNA
-
of special interest, Cloning of the type 5 enzyme, and demonstration of its relative abundance in heart.
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(1992)
J Biol Chem
, vol.267
, pp. 13553-13557
-
-
Ishikawa1
Katsushika2
Chen3
Halnon4
Kawabe5
Homcy6
-
9
-
-
0026744081
-
Two Members of a Widely Expressed Subfamily of Hormone Stimulated Adenylyl Cyclases
-
of outstanding interest, edn l, Cloning of the type 5 and 6 adenylyl Cyclases. Characterization of the type 6 enzyme as a a'Y-subunit-insensitive, Gsa stimulated adenylyl Cyclase. Analyses of relationship among mammalian adenylyl Cyclases. This paper highlights additional regions of homology between members of the subfamilies of adenylyl Cyclases.
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(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 9809-9813
-
-
Premont1
Chen2
Ma3
Ponnapalli4
Iyengar5
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10
-
-
0027497599
-
Cloning and Expression of an Adenylyl Cyclase Localized to the Corpus Striatum
-
of special interest, Cloning of the type 5 enzyme from a striatal cDNA library. The claim that this enzyme is brain-specific is not correct (see also [8 of special interest ,9 of outstanding interest, 13 of special interest, 42]). The observation that within the brain the type 5 enzyme is mainly found in the striatum, however, is corroborated by others. Localization of types 1 and 2 adenylyl Cyclases by in situ hybridization is in agreement with the data from other laboratories (see [19,20]).
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(1993)
Nature
, vol.361
, pp. 536-538
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-
Glatt1
Snyder2
-
13
-
-
0026487069
-
Molecular Diversity in the Adenylyl Cyclase Family. Evidence for Eight Forms of the Enzyme and Cloning of Type VI
-
of special interest, Shows the existence of the type 7 adenylyl Cyclase, and confirms that the presence of the type 8 enzyme is brain-specific. Very limited sequences of types 7 and 8 adenylyl Cyclases are presented.
-
(1992)
J Biol Chem
, vol.267
, pp. 24858-24862
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-
Krupinski1
Legman2
Frankenfield3
Zwaagstra4
Watson5
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16
-
-
0025874613
-
Expression and Characterization of Calmodulin-Activated (Type I) Adenylyl Cyclase
-
2+ sensor. The paper also demonstrates that the two halves of adenylyl cyclase need not be covalently linked to obtain Gs regulated catalytic activity.
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(1991)
J Biol Chem
, vol.266
, pp. 8595-8603
-
-
Tang1
Krupinski2
Gilman3
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17
-
-
0026567423
-
2+/Calmodulin-Responsive Adenylyl Cyclase
-
of special interest, A mutation in the Drosopbila type 1 enzyme is characterized. Conversion of a conserved glycine to arginine in a highly conserved region of the carboxy-terminal cytoplasmic tail results in loss of catalytic activity.
-
(1992)
Cell
, vol.68
, pp. 479-489
-
-
Levin1
Han2
Hwang3
Feinstein4
Davis5
Reed6
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18
-
-
0026701283
-
The Type III Calcium/Calmodulin-Sensitive Adenylyl Cyclase is Not Specific to Olfactory Sensory Neurons
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(1992)
Neurosci Lett
, vol.144
, pp. 169-173
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-
Xia1
Choi2
Wang3
Storm4
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19
-
-
0026100792
-
Distribution of mRNA for the Calmodulin-Sensitive Adenylate Cyclase in Rat Brain: Expression in Areas Associated with Learning and Memory
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(1991)
Neuron
, vol.6
, pp. 431-443
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-
Xia1
Refsdal2
Merchant3
Dorsa4
Storm5
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20
-
-
0027336152
-
2+-Insensitive Adenylyl Cyclases in Rat Brain
-
of special interest, in press, A very detailed study of the in situ distribution of types 1 and 2 adenylyl cyclase mRNAs in various brain regions.
-
(1993)
Synapse
-
-
Mons1
Yoshimura2
Cooper3
-
21
-
-
0026744212
-
Localization of Adenylyl and Guanylyl Cyclase in Rat Brain by in situ Hybridization: Comparison with Calmodulin mRNA Distribution
-
of special interest, Distribution of the type 8 adenylyl Cyclase in regions of the brain by in situ hybridization.
-
(1992)
J Neurosci
, vol.12
, pp. 3350-3360
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-
Matsuoka1
Gium2
Poyard3
Stengel4
Parma5
Gueliaen6
Hanoune7
-
23
-
-
0027200238
-
Inhibition of Cloned Adenylyl Cyclases by Mutant Activated Gia and Specific Suppression of Type 2 Adenylyl Cyclase Inhibition by Phorbol Ester Treatment
-
of outstanding interest, in press, This paper shows for the first time that α-subunit modulation of a G protein/effector function can be regulated in an effector subtype-specific manner. Activated Giainhibits types 2, 3 and 6 adenylyl Cyclases. PKC activation suppresses the G;a inhibition of the type 2 enzyme, but does not affect types 3 and 6 adenylyl Cyclases.
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(1993)
J Biol Chem
-
-
Chen1
Iyengar2
-
24
-
-
0027418233
-
Stimulation of Specific Types of Gs Stimulated Adenylyl Cyclases by Phorbol Ester Treatment
-
of special interest, Effects of PKC activation on the activities of adenylyl Cyclase types 1–6 are analyzed. Type 2 adenylyl Cyclase is demonstrated to be the major functional target for the effects of PKC.
-
(1993)
J Biol Chem
, vol.268
, pp. 3829-3832
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Jacobowitz1
Chen2
Premont3
Iyengar4
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25
-
-
0026681492
-
Stimulation of the Type III Olfactory Adenylyl Cyclase by Calcium and Calmodulin
-
(1992)
Bio. chemistry
, vol.31
, pp. 6492-6498
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Choi1
Xia2
Storm3
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26
-
-
0023645429
-
A Novel Mechanism for the Inhibition of Adenylate Cyclase via Inhibitory GTPBinding Proteins. Calmodulin-Dependent Inhibition of the Cyclase Catalyst by the af-Subunits of GTP-Binding Proteins
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(1987)
J Biol Cbem
, vol.262
, pp. 11897-11900
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Katada1
Kusakabe2
Oinuma3
Ui4
-
27
-
-
0026418426
-
Type-Specific Regulation of Adenylyl Cyclase by G protein βγ subunits
-
sαs-subunits. The data also show that the direction of regulation of the effector by [3y-subunits can be specific for the different types of adenylyl Cyclase. The data presented here give rise to the idea that G-proteins can have multiple effects by differentially regulating different adenylyl Cyclase subtypes.
-
(1991)
Science
, vol.254
, pp. 1500-1503
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Tang1
Gilman2
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29
-
-
0027513980
-
Type Specific Stimulation of Adenylyl Cyclase by Protein Kinase C
-
(1993)
J Biol Chem
, vol.268
, pp. 4604-44607
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Yoshimura1
Cooper2
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32
-
-
0026460414
-
Lowered Responsiveness of the Catalyst of Adenylyl Cyclase to Stimulation by Gs in Heterologous Desensitization: A Role for Adeno sine 3′5′-Monophosphate-Dependent Phosphorylation
-
of special interest, Functional evidence that PKA inhibits adenylyl Cyclase during heterologous desensitization. Type 6 adenylyl Cyclase is identified as a possible target.
-
(1992)
Endocrinology
, vol.131
, pp. 2774-2784
-
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Premont1
Jacobowitz2
Iyengar3
-
33
-
-
0026771948
-
Calcium and Muscarinic Agonist Stimulation of Type I Adenylylcyclase in Whole Cells
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2+.
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(1992)
J Biol Cbem
, vol.267
, pp. 12440-12442
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Choi1
Wong2
Hinds3
Storm4
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38
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0016417439
-
Regulation of Cyclic Adenosine 3′: 5′ Monophosphate Levels in Guinea Pig Cerebral Cortex by Interaction of Alpha Adrenergic and Adenosine Receptor Activity
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(1975)
J Pbarmacol Exp Ther
, vol.192
, pp. 22-32
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Sattin1
Rall2
Zanela3
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39
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0021954015
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Characterization of the Relationship between y-Aminobutyric Acid B Agonists and TransmitterCoupled Cyclic Nucleotide-Generating Systems in Rat Brain
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(1985)
Mol Pbarmacol
, vol.27
, pp. 53-59
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Karbon1
Enna2
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41
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0027526590
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Enhancement of R-Adrenergic Responses by Gi-Linked Receptors in Rat Hippocampus
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(1993)
Neuron
, vol.10
, pp. 83-88
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Andrade1
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