Somatic mutation of APC gene in desmoid tumour in familial adenomatous polyposis

The Lancet

Volumn 342, Issue 8870, 1993, Pages 552-553

  Sen Gupta, S ^a,b   van der Luijt, R B ^a,b   Bowles, L V ^a,b   Khan, P Meera ^a,b   Delhanty, J D A ^a,b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

DESMOID TUMOR; FAMILIAL POLYPOSIS; GENE MUTATION; HUMAN; HUMAN CELL; LETTER; PRIORITY JOURNAL; SOMATIC MUTATION;

ABDOMINAL MUSCLES; ABDOMINAL NEOPLASMS; ADENOMATOUS POLYPOSIS COLI; CASE REPORT; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 5; FIBROMA; GENE EXPRESSION REGULATION; HUMAN; MUTATION; SUPPORT, NON-U.S. GOV'T; TUMOR CELLS, CULTURED;

EID: 0027296465     PISSN: 01406736     EISSN: None     Source Type: Journal    
DOI: 10.1016/0140-6736(93)91677-E     Document Type: Letter

References (8)

1. Localisation of the gene for familial adenomatous polyposis on chromosome 5
2. Somatic mutations of the APC gene in colorectal tumours: mutation cluster region in the APC gene
3. APC mutations occur early during colorectal tumorigenesis
4. Clonal chromosomal abnormalities in desmoid tumours
5. Molecular nature of chromosome 5q loss in colorectal tumors and desmoids from patients with familial adenomatous polyposis
6. Two cases of 5q deletions in patients with familial adenomatous polyposis possible link with Caroli's disease
7. Identification and characterization of the familial adenomatous polyposis coli gene
8. Eight novel germline mutations at the APC gene identified by denaturing gradient gel electrophoresis