Identification of P450 enzymes involved in metabolism of verapamil in humans

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 348, Issue 3, 1993, Pages 332-337

  Kroemer, Heyo K ^a   Gautier, Jean Charles ^b   Beaune, Philipe ^b   Henderson, Colin ^c   Roland Wolf, C ^c   Eichelbaum, Michel ^a  

^a DR MARGARETE FISCHER BOSCH INSTITUTE OF CLINICAL PHARMACOLOGY   (Germany)

^b HÔPITAL NECKER ENFANTS MALADES   (France)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Cytochrome P450; Human liver; Metabolism; Verapamil

Indexed keywords

CYTOCHROME P450 ISOENZYME; DEALKYLVERAPAMIL; DRUG METABOLITE; ENZYME ANTIBODY; ETHOXYRESORUFIN DEETHYLASE; NORVERAPAMIL; O DEMETHYLASE; TESTOSTERONE; UNSPECIFIC MONOOXYGENASE; VERAPAMIL;

ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; GENE EXPRESSION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; LIVER MICROSOME; PARTIAL HEPATECTOMY; PRIORITY JOURNAL; YEAST CELL;

BIOTRANSFORMATION; BLOTTING, WESTERN; CYTOCHROME P-450 ENZYME SYSTEM; HUMAN; IN VITRO; LIVER; MICROSOMES, LIVER; MIXED FUNCTION OXYGENASES; SUPPORT, NON-U.S. GOV'T; VERAPAMIL; YEASTS;

EID: 0027295760     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/BF00169164     Document Type: Article

References (31)

1. Metabolism of verapamil in a family pedigree with deficient N-oxidation of trimethylamine
2. Near total reduction in verapamil bioavailability by rifampicine
3. The pharmacological treatment of atrial fibrillation
4. Identification and characterization of the cytochrome P450 enzymes involved in N-dealkylation of propafenone: molecular base for interaction potential and variable disposition of active metabolites
5. Catalytic activities of human liver cytochrome P-4503A4 expressed sacharomyces cerevisiae
6. Enantioselective N-oxygenation of verapamil by hepatic flavin-containing monooxygenase
7. The metabolism of DL[14C]-verapamil in man
8. Verapamil and drug metabolism by cytochrome P450 isoform CYP1A2
9. The molecular biology of cytochrome P450s
10. Pharmacokinetics and pharmacodynamics of the enantiomers of gallopamil
11. Purification and characterization of liver microsomal cytochrome P450: electrophoretic, spectral, catalytic and immunochemical properties and inducibility of eight isozymes isolated from rats treated with phenobarbital or naphtoflavone
12. Comparison of levels of several human microsomal cytochrome P-450 enzymes and epoxide hydrolase in normal and disease states using immunochemical analysis of surgical liver samples
13. Predictability of the in vivo metabolism of verapamil from in vitro data: contribution of individual metabolic pathways and stereoselective aspects
14. Cyclosporine metabolism in human liver: identification of cytochrome P 450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs
15. Verapamil inhibits cyclosporine metabolism
16. Protein measurement with Folin phenol reagent
17. Dealkylation of pentoxyresorufin: a rapid and sensitive assay for measuring induction of cytochrome(s) P-450 phenobarbital and other xenobiotics in the rat
18. Effects of imidazole derivatives on cytochromes P450 from human hepatocytes in primary cultures
19. Verapamil. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension
20. Hepatic monooxygenase activities in subjects with genetic defect in drug oxidation
21. Interaction of verapamil and cimetidine: stereochemical aspects of drug metabolism, drug disposition and drug action
22. On the substrate specificity of cytochrome P450IIIA 1
23. Regiochemistry and substrate stereoselectivity of O-demethylation of verapamil in the presence of the microsomal fraction from rat and human liver
24. Verapamil-induced inhibition of theophylline in healthy humans
25. The carbon monoxide binding pigment of liver microsomes
26. Effects of chronic phenobarbital on verapamil disposition in humans
27. Furafylline is a potent and selective inhibitor of cytochrome P 4501 A2 in man
28. Human liver microsomal cytochromes P450 mephenytoin 4-hydroxylases a prototype of genetic polymorphism in oxydative drug metabolism. Purification and characterization of two similar forms involved in the reaction
29. Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications
30. Increased quinidine plasma concentrations during administration of verapamil: a new quinidine — verapamil interaction
31. Identification of an inducible form of cytochrome P450 in human liver