The Effectiveness Of A Mixture Of β-Carotene, A-Tocopherol, Glutathione, And Ascorbic Acid For Cancer Prevention

Nutrition and Cancer

Volumn 20, Issue 2, 1993, Pages 145-151

  Shklar, Gerald ^a   Schwartz, Joel ^a   Trickier, Diane ^a   Cheverie, Susan Reid ^a  

^a HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; BETA CAROTENE; GLUTATHIONE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; CANCER INHIBITION; CANCER PREVENTION; CONTROLLED STUDY; DIET SUPPLEMENTATION; DIET THERAPY; MALE; MOUTH CANCER; NONHUMAN; STATISTICAL ANALYSIS; SYRIAN HAMSTER; TUMOR MODEL;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ADMINISTRATION, ORAL; ANIMAL; ASCORBIC ACID; BETA CAROTENE; CAROTENOIDS; DRUG COMBINATIONS; DRUG SYNERGISM; GLUTATHIONE; HAMSTERS; LEUKOPLAKIA; MALE; MESOCRICETUS; MOUTH NEOPLASMS; VITAMIN E;

EID: 0027295593     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635589309514281     Document Type: Article

References (40)

1. Suda, D, Schwartz, J, and Shklar, G: “Inhibition of Experimental Oral Carcinogenesis by Topical Beta-Carotene.” Carcinogenesis 7, 711–715, 1986.
2. Suda, D, Schwartz, J, and Shklar, G: “GGT Reduction in Beta-Carolene Inhibition of Hamster Buccal Pouch Carcinogenesis.” Eur J Cancer Clin Oncol 23, 43-46,1987.
3. Trickier, D, and Shklar, G: “Prevention by Vitamin E of Oral Carcinogenesis.” JNCI 78, 165–169, 1987.
4. Shklar, G, Schwartz, JL, Trickier, DP, and Reid, S: “Prevention of Experimental Cancer and Immunostimulation by Vitamin E (Immunosurveillance).” J Oral Pathol Med 19, 60–64, 1990.
5. Shklar, G, and Schwartz, J: “Tumor Necrosis Factor in Experimental Cancer: Regression With Alpha-Toco-pherol, Beta-Carotene and Algae Extract.” J Cancer Clin Oncol 24, 839–850, 1988.
6. Menkes, MS, Comstock, GW, Vuilleumier, JP, Helsing, KJ, Ridder, AA, et al.: “Serum Beta-Carotene, Vitamins A and E, Selenium, and the Risk of Lung Cancer.” N Engl J Med 315, 1250–1254, 1986.
7. Palan, PR, Mikhail, MS, Basu, J, and Romney, SL: “Plasma Levels of Antioxidants Beta-Carotene and a-Tocopherol in Uterine Cervix Dysplasia and Cancer.” Nutr Cancer 15, 13–20, 1991.
8. Rotstein, JB, and Slaga, TJ: “Effect of Exogenous Glutathione on Tumor Progression in the Murine Skin Multistage Carcinogenesis Model.” Carcinogenesis 9, 1547–1551, 1988.
9. Trickier, D, Shklar, G, and Schwartz, J: “Systemically Administered Glutathione Inhibits DMBA Carcinogenesis of Hamster Buccal Pouch” (abstr). J Dent Res 70, 594, 1990.
10. Packer, JE, Slater, TF, and Wilson, RL: “Direct Observation of a Free Radical Interaction Between Vitamin E and Vitamin C.” Nature 278, 737–739, 1979.
11. Shklar, G, Schwartz, J, Trickier, D, and Reid, S: “Regression of Experimental Cancer by Oral Administration of Combined Alpha-Tocopherol and Beta-Carotene.” Nutr Cancer 12, 321–325, 1989.
12. Palozza, P, and Krinsky, NI: “Beta-Carotene and a-Tocopherol Are Synergistic Antioxidants.” Arch Biochem Biophys 297, 184–187, 1992.
13. Schwartz, JL, Tanaka, V, Khandekar, V, Herman, TS, and Teicher, BA: “P-Carotene and/or Vitamin E as Modulators of Alkylating Agents in SCC-25 Human Squamous Carcinoma Cells.” Cancer Chemother Pharmacol 29, 207–213, 1992.
14. Burton, GW, and Ingold, KU: “p-Carotene: An Unusual Type of Lipid Antioxidant.” Science 224, 569–573, 1984.
15. Schwartz, JL, Antoniades, DZ, and Zhao, S: “Molecular and Biochemical Reprogramming of Oncogenesis Through the Activity of Antioxidants and Prooxidants.” Ann NY Acad Sci 9320, 262–279, 1993.
16. Kuchan, MJ, and Milner, JA: “Influence of Intracellular Glutathione on Selenite-Mediated Growth Inhibition of Canine Mammary Tumor Cells.” Cancer Res 52, 1091–1095, 1992.
17. Biaglow, JE, Vames, ME, Epp, ER, Clark, EP, Tuttle, SW, et al.: “Role of Glutathione and Other Thiols in Cellular Response to Radiation and Drugs.” Drug Metab Rev 20, 1–12, 1989.
18. Zhang, L, and Mock, D: “Alteration in Glutathione Level During Carcinogenesis of Hamster Buccal Pouch Mucosa.” J Dent Res 70, 1061–1063, 1991.
19. Misra, HP: “Generation of Superoxide Free Radical During the Autoxidation of Thiols.” J Biol Chem 249, 2151–2155, 1974.
20. Svingen, BA, O’Neal, FO, and Aust, SD: “The Role of Superoxide and Singlet Oxygen and Lipid Peroxidation.” Photochem Photobiol 28, 803–809, 1978.
21. Morgenstem, R, and DePierre, JW: “Microsomal Glutathione Transferase. “Purification in Unactivated Form and Further Characterization of the Activation Process, Substrate Specificity and Amino Acid Composition.” Eur J Biochem 134, 591–597, 1983.
22. Waxman, AJ: “GIutathione-S-Transferases: Role in Alkylating Agent Resistance and Possible Target for Modulation Chemotherapy—A Review.” Cancer Res 50, 6449–6454, 1990.
23. Nebert, DW, and Negishi, M: “Multiple Forms of Cytochrome P-450 and the Importance of Molecular Biology and Evolution.” Biochem Pharmacol 31, 2311–2321, 1982.
24. Gongales, FJ: “The Molecular Biology of Cytochrome p4505.” Pharmacol Rev 40, 245–253, 1988.
25. Trickier, D, Shklar, G, and Schwartz, J: “Systemically Administered Glutathione Inhibits DMBA Carcinogenesis of Hamster Buccal Pouch” (abstr). J Dent Res 70, 594, 1991.
26. Schwartz, JL, Flynn, E, Trickier, D, and Shklar, G: “Directed Lysis of Experimental Cancer by Beta-Carotene in Liposomes.” Nutr Cancer 16, 124–197, 1991.
27. Shklar, G, and Schwartz, J: “Oral Inhibition by Micronutrients. The Experimental Basis for Clinical Trials.” Oral Oncol Eur J Cancer 29B, 9–16, 1993.
28. Shklar, G, Schwartz, J, and Trickier, D: “Vitamin C Augments DMBA Carcinogenesis of Hamster Buccal Pouch” (abstr). J Dent Res 70, 594, 1991.
29. Slaga, TJ, Gleason, GL, Mills, G, Ewald, L, Fu, PP, et al.: “Comparison of the Skin Tumor-Initiating Activities of Dihydrodiol and Diol-Epoxides of Various Polycyclic Aromatic Hydrocarbons.” Cancer Res 40, 1981–1984, 1980.
30. Golumbic, C, and Mattill, HA: “Antioxidants and the Autoxidants of Fats. XIII. The Antioxygenic Action of Ascorbic Acid in Association With Tocopherols, Hydroquinones, and Related Compounds.” J Am Chem Soc 63, 1279–1280, 1941.
31. McCay, PB: “Vitamin E: Interactions With Free Radicals and Ascorbate.” Amu Rev Nutr 5, 323–340, 1985.
32. Reed, DJ: “Interaction of Vitamin E, Ascorbic Acid, and Glutathione in Protection Against Oxidative Damage.” In Vitamin E in Health and Disease, L Packer and J Fuchs (eds). New York: Dekker, 1993, pp 269–280.
33. Scarpa, M, Rigo, A, Maiorino, M Ursini, R, and Gregolin, C: “Formation of a-Tocophero Radical and Recycling of a-Tocopherol by Ascorbate During Peroxidation of Phosphatidylcholine Liposomes. An Electron Paramagnetic Resonance Study.” Biophys Acta 801, 215–219, 1984.
34. Shklar, G, Trickier, D, and Schwartz, JL: “p53 and Vitamin E Inhibition of Oral Carcinogenesis” (abstr). J Dent Res 78, 285, 1993.
35. Finlay, CA, Hinds, PW, and Levine, AJ: “The p53 Proto-Oncogene Can Act as a Suppressor of Transformation.” Cell 57, 1083–1093, 1989.
36. Landon, JD, and Partridge, M: “Expression of the Tumor Suppression Gene p53 in Oral Cancer.” Br J Oral Maxillofac Surg 30, 214–220, 1992.
37. Gusterson, BA, Anbazhagan, R, Warren, W, Midgely, C, Lane, DP, et al.: “Expression of p53 in Premalignant and Malignant Squamous Epithelium.” Oncogene 6, 1785–1790, 1991.
38. Schwartz, JL, Teicher, BA, and Stringham, JM: “Carotenoids as Cell Cycle Specific Inhibitors” (abstr). Cancer Res 33, 441, 1992.
39. Schwartz, JL: “Beta-Carotene Induced Programmed Cell Death” (abstr). J Dent Res 72, 285, 1993.
40. Weitberg, AB: “Effect of Combinations of Antioxidants on Phagocyte-Induced Sister-Chromatid Exchanges.” Mutat Res 224, 1–4, 1989.