Determination of rate and equilibrium binding constants for macromolecular interactions using surface plasmon resonance: Use of nonlinear least squares analysis methods

Analytical Biochemistry

Volumn 212, Issue 2, 1993, Pages 457-468

  O'Shannessy, Daniel J ^a   Brigham Burke, Michael ^a   Karl Soneson, K ^b   Hensley, Preston ^a   Brooks, Ian ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

^b KKS Software Inc ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; BINDING AFFINITY; MACROMOLECULE; MOLECULAR INTERACTION; PRIORITY JOURNAL; STATISTICS;

ANIMAL; ANTIBODIES, MONOCLONAL; ANTIGENS, CD4; BIOSENSING TECHNIQUES; CHEMISTRY, ANALYTICAL; KINETICS; LEAST-SQUARES ANALYSIS; MACROMOLECULAR SYSTEMS; MATHEMATICAL COMPUTING; MICE; MODELS, BIOLOGICAL; SPECTRUM ANALYSIS;

ASSOCIATION REACTIONS; DISSOCIATION; EQUILIBRIUM CONSTANTS; GOLD COATINGS; LEAST SQUARES APPROXIMATIONS; LIGANDS; LINEAR TRANSFORMATIONS; PLASMONS; SURFACE PLASMON RESONANCE;

ASSOCIATION RATE CONSTANTS; DISSOCIATION PROCESS; DISSOCIATION RATE CONSTANT; EQUILIBRIUM BINDING CONSTANT; INTEGRATED RATE EQUATIONS; NON-LINEAR LEAST SQUARES; NONLINEAR LEAST SQUARES METHODS; OPTICAL DETECTION METHODS;

RATE CONSTANTS;

EID: 0027293351     PISSN: 00032697     EISSN: 10960309     Source Type: Journal    
DOI: 10.1006/abio.1993.1355     Document Type: Article

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