An investigation of the filtration capacity and the fate of large filtered sterically-stabilized microspheres in rat spleen

BBA - General Subjects

Volumn 1157, Issue 2, 1993, Pages 233-240

  Moghimi, S M ^a   Hedeman, H ^a   Muir, I S ^a   Illum, L ^a   Davis, S S ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Drug carrier; Filtration; Kupffer cells; Liver (Rat); Microsphere; Spleen; Spleen macrophages

Indexed keywords

DRUG CARRIER; MICROSPHERE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; FILTRATION; KUPFFER CELL; MACROPHAGE; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SPLEEN;

ANIMAL; ETHYLENEDIAMINES; FILTRATION; LATEX; LIVER; MACROPHAGES; MALE; MICROSPHERES; OPSONINS; POLYETHYLENE GLYCOLS; RATS; RATS, WISTAR; SPLEEN; SUPPORT, NON-U.S. GOV'T; TIME FACTORS;

EID: 0027292348     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/0304-4165(93)90105-H     Document Type: Article

References (25)

1. Activity of amphipathic poly(ethylene glycol) 5000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposome binding to target
2. Role of liposome size and RES blockade in controlling biodistribution and tumor uptake of GM1-containing liposomes