The effect of hemodialysis on protein metabolism: A leucine kinetic study

Journal of Clinical Investigation

Volumn 91, Issue 6, 1993, Pages 2429-2436

  Lim, Victoria S ^a   Bier, Dennis M ^b   Flanigan, Michael J ^b   Sum Ping, Sam T ^b  

^a UNIVERSITY OF IOWA HOSPITALS AND CLINICS   (United States)

^b NONE

Author keywords

Hemodialysis; Leucine kinetics; Protein flux

Indexed keywords

2 OXOISOCAPROIC ACID; BICARBONATE; CUPROPHANE; LEUCINE;

ADULT; AMINO ACID BLOOD LEVEL; AMINO ACID TRANSPORT; ARTICLE; CLINICAL ARTICLE; DIALYSATE; FEMALE; HEMODIALYSIS; HUMAN; MALE; OXIDATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN METABOLISM; PROTEIN SYNTHESIS;

ADULT; BICARBONATES; CARBON DIOXIDE; CARBON ISOTOPES; FEMALE; HUMAN; KETO ACIDS; KINETICS; LEUCINE; MALE; MIDDLE AGE; PROTEINS; RENAL DIALYSIS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027289732     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI116477     Document Type: Article

References (31)

1. Bergstrom, J., A. Alvestrand. and A. Gutierrez. 1986. Acute and chronic metabolic effects of hemodialysis. In Immune and Metabolic Aspects of Therapeutic Blood Purification Systems: Proceedings of the International Symposium on Purification Systems. L. Smeby. S. Jorstead, and T.-E. Wideroe, editors. Karger. Basel, Switzerland/New York. 254-273.
2. Heidland, A., R. M. Schaefer, E. Heidbreder, and W. H. Horl. 1988. Catabolic factors in renal failure: therapeutic approaches. Nephrol. Dial. Transplant. 3:8-16.
3. Heidland, A., W. H. Horl, N. Heller, H. Heine, S. Neumann, and E. Heidbreder. 1983. Proteolytic enzymes and cataholism: enhanced release of granulocyte proteinases in uremic intoxication and during hemodialysis. Kidney Int. Suppl. 24:S27-S36.
4. Kopple, J. D., M. E. Swendseid, J. H. Shinaherger, and C. Y. Umezawa CY. 1973. The free and bound amino acids removed by hemodialysis. Trans. Am. Soc. Artif. Intern. Organs. 19:309-313.
5. Tepper, T., G. K. Van Der Hem, H. G. Klip, and A. J. M. Donker. 1981. Loss of amino acids during hemodialysis. Effect of oral essential amino acid supplementation. Nephron. 29:25-29.
6. Wolfson, M., M. R. Jones, and J. D. Kopple. 1982. Amino acid losses during hemodialysis with infusion of amino acids and glucose. Kidney Int. 21:500-506.
7. Farrell, P. C., and P. W. Hone. 1980. Dialysis-induced catabolism. Am. J. Clin. Nutr. 33:1417-1422.
8. Ward, R. A., M. J. Shirlow, J. M. Haves, G. V. Chapman, and P. C. Farrell. 1979. Protein catabolism during hemodialysis. Am. J. Clin. Nutr. 32:2443-2449.
9. Borah, M. F., P. Y. Schoenteld, F. A. Gotch, J. A. Sargent, M. Wolfson, and M. H. Humphreys. 1978. Nitrogen balance during intermittent dialysis therapy of uremia. Kidney Int. 14:491-500.
10. Lim, V. S., and M. J. Flanigan. 1989. The effect of interdialytic interval on protein metabolism: evidence suggesting dialysis-induced catabolism. Am. J. Kidney Dis. 14:96-100.
11. Pedrini. L. A., S. Zereik, and S. Rasmy. 1988. Causes, kinetics and clinical implications of post-hemodialysis urea rebound. Kidney Int. 34:817-824.
12. Bier, D. M. 1989. Intrinsically difficult problems: the kinetics of body proteins and amino acids in man. Diabetes Metab. Rev. 5:111-132.
13. Gotch, F. A. 1986. Kinetics of hemodialysis. Artif. Organs. 10:272-281.
14. Gutierrez, A., A. Alvestrand, J. Wahren, and J. Bergstrom. 1990. Effect of in vivo contact between blood and dialysis membranes on protein catabolism in humans. Kidney Int. 38:487-494.
15. Lim, V. S., M. J. Flanigan, and J. Fangman. 1990. Effect of hematocrit on solute removal during high efficiency hemodialysis. Kidney Int 37:1557-1562.
16. Matthews, D. E., K.J. Motil, D. K. Rohrbaugh, J. F. Burke, V. R. Young, and D. M. Bier. 1980. Measurement of leucine metabolism in man from a primed, continuous infusion of L-[1-13C] lcucine. Am. J. Physiol. 238:473-E479.
17. Motil, K. J., D. E. Matthews, D. M. Bier, J. F. Burke, H. N. Munro, and V. R. Young. 1981. Whole-body leucine and lysine metabolism: response to dietary protein intake in young men. Am. J. Physiol. 240:E712-E721.
18. Matthews, D. E., D. M. Bier, M. J. Rennie, R. H. T. Edwards, D. Halliday, D. J. Millward, and G. A. Clugston. 1981. Regulation of leucine metabolism in man: a stable isotope study. Science (Wash. DC). 214:1129-1131.
19. Bier, D. M., D. E. Matthews, and V. R. Young. 1985. Interpretation of amino acid kinetic studies in the context of whole-body protein metabolism. In Substrate and Energy Metabolism. J. S. Garrow and D. Halliday, editors. John Libbey. London. 27-36.
20. 13C] leucine infusion in man: a method for measuring human intracellular leucine tracer enrichment. Metabolism 31:1105-1112.
21. Schwenk, W. F., B. Beaufrere, and M. W. Haymond. 1985. Use of reciprocal pool specific activities to model leucine metabolism in humans. Am. J. Physiol. 249:E646-E650.
22. Matthews, D. E., E. Ben-Galim, and D. M. Bier. 1979. Determination of stable isotopic enrichment in individual plasma amino acids by chemical ionization mass spectrometry. Anal. Chem. 51:80-84.
23. Schwarz, H. P., I. E. Karl, and D. M. Bier. 1980. The a-keto acids: simplified derivatization for physiological samples and complete separation as quinoxalinols by packed column gas chromatography. Anal Biochem. 108:360-366.
24. Cohen, S. A., T. L. Tarvin, and B. A. Bidlingmeyer. 1984. Analysis of amino acids. Am. Lab. (Shelton). 16:48-59.
25. Westenskow, D. R., C. A. Culler, and W. D. Wallace. 1984. Instrumentation for monitoring gas exchange and metabolic rate in critically ill patients. Crit. Care Med. 12:183-187.
26. Adrogue, H., J. Brensilver, J. Cohen, and N. Madias. 1983. Influence of steady-state alterations in acid-base equilibrium on the fate of administered bicarbonate in the dog. J Clin. Invest. 71:867-883.
27. Tolchin, N., J. Roberts, and E. Lewis. 1978. Respiratory gas exchange by high-efficiency hemodialyzers. Nephron. 21:137-145.
28. Alvestrand, A., P. Furst, and J. Bergstrom. 1982. Plasma and muscle free amino acids in uremia: influence of nutrition with amino acids. Clin. Nephrol. 18:297-305.
29. Alvestrand, A., P. Furst, and J. Bergstrom. 1983. Intracellular amino acids in uremia. Kidney Int. Suppl. 24:S9-S16.
30. Lindsay, R. M., and E. Spanner. 1989. A hypothesis: the protein catabolic rate is dependent upon the type and amount of treatment in dialyzed uremic patients. Am. J. Kidney Dis. 13:382-389.
31. Luger, A., J. Kovaric, H. K. Stummvoll, A. Urbanska, and T. A. Luger. 1987. Blood-membrane interaction in hemodialysis leads to increased cytokine production. Kidney Int. 32:84-88.