An improved extraction method for the HPLC determination of morphine and its metabolites in plasma

Journal of Pharmaceutical and Biomedical Analysis

Volumn 11, Issue 4-5, 1993, Pages 401-406

  Pawula, Maria ^a   Barrett, David A ^a   Shaw, P Nicholas ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

High performance liquid chromatography; morphine; morphine 3 glucuronide; morphine 6 glucuronide; plasma.; solid phase extraction

Indexed keywords

DRUG METABOLITE; MORPHINE; MORPHINE 3 GLUCURONIDE; MORPHINE 6 GLUCURONIDE; NORMORPHINE;

ANIMAL TISSUE; ARTICLE; DRUG BLOOD LEVEL; DRUG METABOLISM; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; SOLID PHASE EXTRACTION;

ANIMAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ELECTROCHEMISTRY; HYDROGEN-ION CONCENTRATION; INJECTIONS, INTRAVENOUS; MORPHINE; MORPHINE DERIVATIVES; SHEEP; SPECTROMETRY, FLUORESCENCE;

EID: 0027289542     PISSN: 07317085     EISSN: None     Source Type: Journal    
DOI: 10.1016/0731-7085(93)80036-Z     Document Type: Article

References (19)

1. Direct determination of codeine, norcodeine, morphine and normorphine with their corresponding O-glucuronide conjugates by high-performance liquid chromatography with electrochemical detection