메뉴 건너뛰기




Volumn 3, Issue 6, 1993, Pages 1035-1040

Stable isosteres of neurotensin c-terminal pentapeptides derived by modification of the amide function

Author keywords

[No Author keywords available]

Indexed keywords

NEUROTENSIN DERIVATIVE; NEUROTENSIN RECEPTOR; NEUROTENSIN[9-13][9 LYSINE]; PENTAPEPTIDE; UNCLASSIFIED DRUG;

EID: 0027286213     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)80282-6     Document Type: Article
Times cited : (27)

References (20)
  • 1
    • 0015821329 scopus 로고
    • The Isolation of a New Hypotensive Peptide, Neurotensin, from Bovine Hypothalami
    • (1973) J. Biol. Chem. , vol.248 , pp. 6854-6861
    • Carraway1    Leeman2
  • 3
    • 0022623486 scopus 로고
    • The Interaction of Neurotensin with Dopaminergic Pathways in the Central Nervous System: Basic Neurobiology and Implications for the Pathogenesis and Treatment of Schizophrenia
    • (1986) Psychoneuroendochrinology , vol.11 , pp. 15-37
    • Nemeroff1
  • 7
    • 0002463274 scopus 로고
    • Enzymatic Barriers to Peptide and Protein Absorption and the use of Penetration Enhancers to Modify Absorption
    • S.S. Davis, L. Illum, E. Tomlinson, Plenum Press, New York
    • (1986) Delivery Systems for Peptides Drugs , pp. 87-104
    • Lee1
  • 10
    • 84913175820 scopus 로고    scopus 로고
    • Cain, Gary A. et al., Manuscript submitted for publication in J. Med. Chem.
  • 11
    • 0019947041 scopus 로고
    • New Methods and Reagents in Organic Synthesis; A Practical Method for Preparation of Optically Active N-Protected α-Amino Aldehydes and Peptide Aldehydes
    • (1982) Chem. Pharm. Bull. , vol.30 , pp. 1921-1924
    • Hamada1    Shioiri2
  • 12
    • 84913175819 scopus 로고    scopus 로고
    • Mixed anhydride coupling using isobutyl chloroformate of the appropriate BOC protected amine and benzyl protected -COOH amino acids; BOC deprotection using 4 M HCl in dioxane; benzyl deprotection hydrogenation.
  • 14
    • 0141610329 scopus 로고
    • Naloxone-inaccessible σ Receptor in Rat Central Nervous System
    • d is it's dissociation constant.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 6703-6707
    • Tam1
  • 16
    • 84873776176 scopus 로고
    • A method for Evaluating both Non-Narcotic and Narcotic Analgesics
    • b. Test compounds for i.v. administration were suspended in an aqueous vehicle containing 2% by volume of Tween ® 80. I.V. doses were administered in a volume of 10 ml/kg body weight and are expressed as mg/kg doses. For i.c.v. administration, compounds were dissolved in 100% dimethylsulfoxide. Unilateral i.c.v. doses were injected in a volume of 5 microliters and are expressed as microgram/mouse doses. Test compounds were administered i.c.v. or i.v. to fasted (17–21 hours) male white mice (CF1), 5–15 animals per graded dose. After 5 minutes, aqueous 0.01% phenyl-p-benzoquinone, 0.125 mg/kg, was injected intraperitoneally. After the additional time indicated in the table, mice were observed for 10 minutes for the charateristic stretching or writhing [[Truncated]]
    • (1957) Proc. Soc. Exp. Biol. Med. , vol.95 , pp. 729-731
    • Seigmund1    Cadumus2    Lu3
  • 17
    • 70449139880 scopus 로고
    • Pharmacological Effects Produced by Intracerebral Injection of Drugs in the Conscious Mouse
    • (1957) Br. J. Pharmacol. , vol.12 , pp. 12-15
    • Haley1    McCormick2
  • 18
    • 84957354361 scopus 로고
    • Use of Moving Averages and Interpolation to Estimate Median-Effective Dose
    • (1947) Bac. Rev. , vol.11 , pp. 115-145
    • Thompson1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.