Penicillin-Binding Protein Expression at Different Growth Stages Determines Penicillin Efficacy In Vitro and In Vivo: An Explanation for the Inoculum Effect

Journal of Infectious Diseases

Volumn 167, Issue 6, 1993, Pages 1401-1405

  Stevens, Dennis L ^a,b,c   Van, Sizhuang ^a,b,c   Bryant, Amy E ^a,b,c  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF IDAHO   (United States)

^c Boise VA Medical Center   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA LACTAM ANTIBIOTIC; CLINDAMYCIN; PENICILLIN G;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBIOTIC SENSITIVITY; ARTICLE; BACTERIAL GROWTH; DRUG EFFICACY; DRUG PROTEIN BINDING; GROWTH CURVE; INOCULATION; MINIMUM INHIBITORY CONCENTRATION; MOUSE; MYOSITIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; STREPTOCOCCUS INFECTION; STREPTOCOCCUS PYOGENES;

ANIMAL; CARRIER PROTEINS; KINETICS; MICE; MICROBIAL SENSITIVITY TESTS; MURAMOYLPENTAPEPTIDE CARBOXYPEPTIDASE; MYOSITIS; PENICILLINS; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PYOGENES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.;

EID: 0027285367     PISSN: 00221899     EISSN: 15376613     Source Type: Journal    
DOI: 10.1093/infdis/167.6.1401     Document Type: Article

References (22)

1. Kirby WMM, Bacteriostatic and lytic actions of penicillin on sensitive and resistant staphylococci, J Clin Invest 1945; 24: 165-9.
2. Eagle H, Experimental approach to the problem of treatment failure with penicillin, I, Group A streptococcal infection in mice, Am J Med 1952; 13: 389-99.
3. Stevens DL, Gibbons AE, Bergstrom R, Winn V, The Eagle effect revisited: efficacy ofclindamycin, erythromycin, and penicillin in the treatment of streptococcal myositis, J Infect Dis 1988; 158: 23-8.
4. Stratton CW IV, In vitro testing: correlation between bacterial susceptibility, body fluid levels and effectiveness of antibacterial therapy, In: Lorian V, ed, Antibiotics in laboratory medicine, Baltimore: Williams & Wilkins, 1991: 849-79.
5. Zak O, Sande MA, Correlation of in vitro antimicrobial activity ofantibiotics with results of treatment in experimental animal models and human infection, In: Sabath LD, ed, Action ofantibiotics in patients, Bern, Switzerland: Hans Huber, 1992: 55-67.
6. Tuomanen E, Cozens R, Tosch W, Zak O, Tomasz A, The rate of killing of Escherichia coli by beta-Iactam antibiotics is strictly proportional to the rate of bacterial growth, J Gen Microbiol 1986; 132: 1297-304.
7. Bryan L, Godfrey A, Beta-Iactam antibiotics: mode ofaction and bacterial resistance, In: Lorian V, ed, Antibiotics in laboratory medicine, Baltimore: Williams & Wilkins, 1991: 599-664.
8. Blaszczak LC, Halligan NG, Radioiododentannylation, Convenient synthesis of a stable penicillin derivative for rapid penicillin binding protein (PBP) assay, J Labelled Compounds Radiopharm 1988; 17: 401-6.
9. Preston DA, Wu CYE, Blaszczak LC, Seitz DE, Halligan NG, Biological characterization of a new radioactive labeling reagent for bacterial penicillin-binding proteins, Antimicrob Agents Chemother 1990; 34: 718-21.
10. Stevens DL, Tanner MH, Winship J, Reappearance of scarlet fever toxin A among streptococci in the Rocky Mountain West: severe group A streptococcal infections associated with a toxic shocklike syndrome, N Engl J Med 1989; 321: 1-7.
11. Holm SE, Tornovist ID, Cars O, Paradoxical effects of antibiotics, Scand J Infect Dis 1991; 74(suppl): 113-7.
12. Kim KS, Kaplan EL, Association of penicillin tolerance with failure to eradicate group A streptococci from patients with pharyngitis, J Pediatr 1985; 107: 681-4.
13. Gastanaduy AS, Kaplan EL, Huwe BB, McKay C, Wannamaker LW, Failure of penicillin to eradicate group A streptococci during an outbreak of pharyngitis, Lancet 1980; 2: 498-502.
14. Brook I, Role of beta-Iactamase-producing bacteria in the failure of penicillin to eradicate group A streptococci, Pediatr Infect Dis 1985; 4: 491-5.
15. Feldman WE, Concentration of bacteria in cerebrospinal fluid of patients with bacterial meningitis, J Pediatr 1976; 88: 549-52.
16. Benjamin WH Jr, Posey BS, Briles D, Effects of in vitro growth phase on the pathogenesis of Salmonella typhimurium in mice, J Gen MicroBiol 1986; 132: 1283-95.
17. Brown MRW, Williams P, The influence of environment on the evelope properties affecting survival of bacteria in infections, Annu Rev Microbiol 1985; 39: 527-56.
18. Mendelman PM, Chaffin DO, Two penicillin binding proteins of Haemophilus influenzae are lost after cells enter stationary phase, FEMS Microbiol Lett 1985; 30: 399-402.
19. Gemmell CG, Peterson PK, Schmeling D, Potentiation ofopsonization and phagocytosis of Streptococcus pyogenes following growth in the presence ofclindamycin, J Clin Invest 1981; 67: 1249-56.
20. Stevens DL, Invasive group A streptococcus infections, Clin Infect Dis 1992; 14: 2-13.
21. Kessler CM, Nussbaum E, Tuazon CU, Disseminated intravascular coagulation associated with Staphylococcus aureus septicemia is mediated by peptidoglycan-induced platelet aggregation, J Infect Dis 1991; 164: 101-7.
22. Peterson PK, Schmeling D, Cleary PP, Wilkinson BH, Kim Y, Quie PG, Inhibition of alternative complement pathway opsonization by group A streptococcal M protein, J Infect Dis 1979; 139: 575-85.