Mechanisms of Action of Cyclosporine: Considerations for the Treatment of Autoimmune Diseases

Clinical Immunology and Immunopathology

Volumn 68, Issue 2, 1993, Pages 220-228

  Hess, Allan D ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOSPORIN;

AUTOIMMUNITY; CONFERENCE PAPER; HUMAN; IMMUNE RESPONSE; MYOCARDITIS; PRIORITY JOURNAL;

AMINO ACID ISOMERASES; ANIMAL; AUTOIMMUNE DISEASES; CALMODULIN; CARRIER PROTEINS; CYCLOSPORINE; HUMAN; IMMUNITY; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; LYMPHOKINES; PEPTIDYLPROLYL ISOMERASE; RECEPTORS, INTERLEUKIN-2; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0027281611     PISSN: 00901229     EISSN: None     Source Type: Journal    
DOI: 10.1006/clin.1993.1122     Document Type: Article

References (41)

1. Altma, A., Coggeshall, and Mustelin, T., Molecular events mediating T cell activation. Adv. Immunol. 48, 227-360, 1990.
2. Borel, J. F., Pharmacology of cyclosporine IV. Pharmacological properties in vivo. Pharmacol. Rev. 41, 259-371, 1989.
3. Borel, J. F., Feurer, C., Gubler, H. U., and Stahelin, H., Biological effect of cyclosporine A: A new antilymphocyte agent. Agents Actions 6, 468-475, 1976.
4. Borel, J. F., Feurer, C., Magnee, C., and Stahelin, H., Effects of the new antilymphocytic peptide cyclosporin A in animals. Am. munolagy 32, 1017-1025, 1977.
5. Bunjes, D., Hardt, C., Rollinghoff, M., and Wagner, H., Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2. Eur. J. Immunol. 8, 657-662, 1981.
6. Citterio, F., and Kahan, B. P., Effects of cyclosporine on nuclear function. Transplant. Proc. 20(Suppl. 2), 75-79, 1988.
7. Colombani, P. M., Robb, A., and Hess, A. D., Cyclosporin A binding to calmodulin: A possible site of action on T-lymphocytes. Science 228, 337-339, 1985.
8. Di Padova, F. E., Pharmacology of cyclosporine. V. Pharmacological effects on immune function: in vitro studies. Pharmacol. Rev. 41, 373-405, 1989.
9. Elliott, J. F., Lin, Y., Mizel, S. B., Bleackley, R. C., Hamish, D, G., and Paetkau, V., Induction of interleukin 2 messenger RNA inhibited by cyclosporin A. Science 226, 1439-1141, 1984.
10. Fisch, G., Wittman-Liebold, B., Lanf, K., Kiefhaber, T., and Schmid, F. X., Cyclophilin and peptidyl-prolyl-ds-¿rcms isomerase are probably identical proteins. Nature 337, 476-479, 1989.
11. Foxwell, B. M. J., Siman, J., Herrero, I. J., Taylor, D., Woerly, G., Cantrell, D., and Ryffel, B., Anti-CD3 antibody induced expression of both p55 and p75 chains of the high affinity IL-2 receptor on human T lymphocytes is inhibited by cyclosporin A. Immunology 69, 104-109, 1990.
12. Granelli-Pipemo, A., In situ hybridization for interleukin 2 and interleukin 2 receptor m RNA in T cells activated in the presence and absence of Cs A. J. Exp. Med. 168, 1649-1658, 1988.
13. Granelli-Piperno, A., Inaba, K., and Steinman, R., Stimulation of lymphokine release from T lymphoblasts. Requirement for m RNA synthesis and inhibition by cyclosporin A. J. Exp. Med. 160, 1792-1801, 1984.
14. Handschumacher, R. E., Harding, M. W., Rice, J., and Drugge, R. J., Cyclophilin: A specific cytosolic binding protein for cyclosporin A. Science 226, 544-546, 1984.
15. Heeg, K., Gillis, S., and Wagner, N., IL-4 bypassed the immune suppressive effect of Cyclosporin A during the in vitro induction of immune cytotoxic T lymphocytes. J. Immunol 141, 2330-2337, 1988.
16. Hess, A. D., Effect of interleukin 2 on the immunosuppressive action of cyclosporine. TYaaspianiiaiion, 39, 62-68, 1985.
17. Hess, A. D., and Bright, E. C., The effect of the CD 28 activation pathway on the immunosuppressive action of cyclosporine. Transplantation 51, 1232-1240, 1991.
18. Hess, A. D., Esa, A. N., and Colombani, P. M., Mechanisms of action of cyclosporine: Effect on cells of the immune system and on subcellular events in T cell activation. Transplant. Proc. 20(Suppl. 2), 29-40, 1988.
19. Hess, A. D., Tutschka, P. J., Pu, Z., and Santos, G. W., Effect of cyclosporin A on human lymphocyte responses in vitro. IV. Production of T cell stimulatory growth factors and development of responsiveness to these growth factors in Cs A-treated primary MLR cultures. J. Immunol. 128, 360-365, 1982.
20. Hess, A. D., Tutschka, P. J., and Santos, G. W., Effect of cyclosporine on the induction of cytotoxic T lymphocytes: Role of interleukin 1 and interleukin 2. Transplant. Proc. 15, 2248-2257, 1983.
21. Hodgkin, P. D., Hapel, A. J., Johnson, R. M., Yound, I. G., and Lafferty, K. J., Blocking of the delivery of the antigen-mediated signal to the nucleus of T cells by cyclosporine. Transplantation 43, 685-691, 1987.
22. June, C. H., Ledbetter, J. A., Gellespie, M. M., Lindtsen, T., and Thompson, C. B., T cell proliferation involving the CD 28 pathway is associated with cyclosporine-resistant interleukin 2 gene expression. Mol. Cell Biol., 7, 4472-4481, 1987.
23. Kahan, B. D., Cyclosporine. N. Engl. J. Med. 21, 1725-1738, 1989.
24. Kay, J, E., Benzier, C. R., and Borghetti, A. F., Effect of cyclosporin A on lymphocyte activation by the calcium ionophore A23187. Immunology 50, 441-449, 1983.
25. Keown, P. A., Emerging indications for the use of cyclosporin in organ transplantation and autoimmunity. Drugs 40, 315-325, 1990.
26. Larsson, E. L., Cyclosporin A and dexamethasone suppress T cell responses by selectively acting at distinct sites of the triggering process. J. Immunol. 124, 2828-2834, 1980.
27. Le Guee, D., Turner, R., Weisbrodt, N., and Dedman, J., Does the binding of cyclosporine to calmodulin result in immunosuppression? Science 234, 68-70, 1986.
28. Lillehoj, H. S., Malek, T. R., and Shevach, E. M., Differential effect of cyclosporin A on the expression of T and B lymphocyte activation antigens. J. Immunol, 133, 244-252, 1984.
29. Morris, P. J., Cyclosporin A. Transplantation 32, 349-354, 1981.
30. Miyawaki, T., Yachie, A., Ohzeki, S., Nagoaki, T., and Taniguchi, N., Cyclosporin A does not prevent expression of TAC antigen, a probable TCGF receptor molecule on mitogen stimulated human T cells. J. Immunol. 130, 2737-2743, 1983.
31. Palacios, R., and Moller, G., Cyclosporin A blocks receptors for HLA-DR antigens on T cells. Nature 290, 792-794, 1981.
32. Reed, J. C., Prystowsky, M. B., and Nowell, P. C., Regulation of gene expression in lectin-stimulated or lymphokine-stimulated T lymphocytes. Transplantation 26(Suppl.), 85-91, 1988.
33. Ryffel, B., Pharmacology of cyclosporine VI. Cellular activation: Regulation of intracellular events by cyclosporine. Pharmacol. Rev. 41, 407-422, 1989.
34. Sigal, N. H., Dumont, F., Durette, P., Siekierka, J. J., Peterson, L., Rich, D. H., Dunlap, B. E., Staruch, M. J., Melino, M. R., Koprak, S. L., Williams, D., Witzel, B., and Pisano, J., Is cyclophilin involved in the immunosuppressive and nephrotoxic mechanism of action of cyclosporin A. J. Exp. Med. 173, 619-628, 1991.
35. Ullman, K. S., Northrop, J. P., Verweji, C. L., and Crabtree, G. R., Transmission of signals from the T lymphocyte antigen receptor to the genes responsible for cell proliferation and immune function: The missing link. Annu. Rev. Immunol. 8, 421-443, 1990.
36. Wagner, H., Cyclosporine A: mechanism of action. Transplant Proc. 15, 523-526, 1983.
37. Wagner, H., Hardt, C., Rouse, B., Rollinghoff, M., Scheurich, P., and Pfizermaier, F., Dissection of the proliferative and differentiative signals controlling murine cytotoxic T lymphocyte responses. J. Exp. Med. 155, 1876-1885, 1982.
38. Wells, M. S., Vogelsang, G. B., Colombani, P. M., and Hess, A. D., Cyclosporine binding to calmodulin. Transplant. Proc. 21, 850-853, 1989.
39. Wenger, R. M., Pharmacology of cyclosporin II chemistry. Pharmacol. Rev. 41, 243-247, 1989.
40. Lin, J., Farmer, J. D., Lane, W. S., Friedman, J., Weissman, I., and Schreiber, S. L., Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK06 complexes. Cell 66, 807-815, 1991.
41. Schreier, M. H., Bauman, G., and Zenke, F., Inhibition of T-Cell signalling pathways by immunophilin drug complexes: Are side effects inherent to immunosuppressive properties? Transplant. Proc. 25, 502-507, 1993.