The significance of low bcl-2 expression by CD45RO T cells in normal individuals and patients with acute viral infections. The role of apoptosis in T cell memory

Journal of Experimental Medicine

Volumn 178, Issue 2, 1993, Pages 427-438

  Akbar, Arne N ^a   Borthwick, Nicola ^a   Salmon, Michael ^b   Gombert, Wendy ^a   Boftll, Margarita ^a   Shamsadeen, Nazarin ^b   Pilling, Darrell ^b   Pett, Sarah ^c   Grundy, Jane E ^a   Janossy, George ^a  

^a ROYAL FREE HOSPITAL   (United Kingdom)

^b UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^c Department of Infectious and Tropical Diseases   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

LYMPHOCYTE ANTIGEN;

APOPTOSIS; ARTICLE; CELL SURVIVAL; CHICKENPOX; CLINICAL ARTICLE; CONTROLLED STUDY; EPSTEIN BARR VIRUS; FEMALE; GENE EXPRESSION; HERPES ZOSTER; HUMAN; HUMAN CELL; IMMUNOLOGICAL MEMORY; INFECTIOUS MONONUCLEOSIS; MALE; PRIORITY JOURNAL; PROTO ONCOGENE; T LYMPHOCYTE ACTIVATION;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ACUTE DISEASE; ADULT; ANTIGENS, CD45; APOPTOSIS; BIOPSY; CELLS, CULTURED; CHICKENPOX; FEMALE; FIBROBLASTS; HUMANS; IMMUNOLOGIC MEMORY; INFECTIOUS MONONUCLEOSIS; INTERLEUKIN-2; LYMPH NODES; LYMPHOCYTE ACTIVATION; MALE; MIDDLE AGED; PROTEIN-TYROSINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; T-LYMPHOCYTE SUBSETS; VIRUS DISEASES;

EID: 0027281563     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.178.2.427     Document Type: Article

References (47)

1. Korsmeyer, S.J. 1992. Bcl-2 initiates a new category of oncogenes: Regulators of cell death. Blood.80:879.
2. Tsujimoto, Y., J. Gorham, J. Cossman, E. Jaffe, and C.M. Croce. 1985. The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining. Science (Wash. DC).229:1390.
3. Korsmeyer, S.J. 1992. Bcl-2: a repressor of lymphocyte death. Immunol. Today.13:285.
4. Hockenbery, D.M., M. Zutter, W. Hickey, M. Nahm, and S.J. Korsmeyer. 1991. BCL2 protein is topographically restricted in tissues characterized by apoptotic cell death. Proc. Natl. Acad. Sci. USA.88:6961.
5. Liu, Y.J., D.E. Joshua, G.T. Williams, C.A. Smith, J. Gordon, and I.C. Maclennan. 1989. Mechanism of antigen-driven selection in germinal centres. Nature (Lond.).342:929.
6. Liu, Y.J., D.Y. Mason, G.D. Johnson, S. Abbot, C.D. Gregory, D.L. Hardie, J. Gordon, and I.C. Maclenan. 1991. Germinal center cells express bcl-2 protein after activation by signals which prevent their entry into apoptosis. Eur. J. Immunol.21:1905.
7. Raff, M.C. 1992. Social controls on cell survival and cell death. Nature (Lond.).356:397.
8. Williams, G.T. 1991. Programmed cell death: apoptosis and oncogenesis. Cell.65:1097.
9. Sentman, C.L., J.R. Shutter, D. Hockenbery, O. Kanagawa, and S.J. Korsmeyer. 1991. Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell.67:879.
10. Nunez, G., D. Hockenbery, T.J. Mcdonnell, C.M. Sorensen, and S.J. Korsmeyer. 1991. Bcl-2 maintains B cell memory. Nature (Lond.).353:71.
11. Strasser, A., S. Whittingham, D.L. Vaux, M.L. Bath, J.M. Adams, S. Cory, and A.W. Harris. 1991. Enforced BCL2 expression in B-lymphoid cells prolongs antibody responses and elicits autoimmune disease. Proc. Natl. Acad. Sci. USA.88:8661.
12. Siegel, R.M., M. Katsumata, T. Miyashita, D.C. Louie, M.L Greene, and J.C. Reed. 1992. Inhibition of thymocyte apoptosis and negative antigenic selection in bcl-2 transgenic mice. Proc. Natl. Acad. Sci. USA.89:7003.
13. Cheeseman, S.H. 1988. Infectious mononucleosis. Semin. Hematol.25:261.
14. + T cells as a sign of in vivo activation in infectious mononucleosis. Clin. Exp. Immunol. 83:447.
15. Cauda, R., C.E. Grossi, R.J. Whitley, and A.B. Tilden. 1987. Analysis of immune function in herpes zoster patients: demonstration and characterization of suppressor cells. J. Immunol. 138:1229.
16. Rickinson, A.B., D.J. Moss, L.E. Wallace, M. Rowe, I.S. Misko, M.A. Epstein, and J.H. Pope. 1981. Long-term T-cell-mediated immunity to Epstein-Barr virus. Cancer Res.41:4216.
17. Beverley, P.C.L. 1990. Is T-cell memory maintained by crossreactive stimulation?Immunol. Today.11:203.
18. Sanders, M.E., M.W. Makgoba, and S. Shaw. 1988. Human naive and memory T cells: reinterpretation of helper inducer and suppressor inducer subsets. Immunol. Today.9:195.
19. Akbar, A.N., M. Salmon, and G. Janossy. 1991. The synergy between naive and memory T cells during activation.Immunol. Today.12:184.
20. Clement, L.T. 1992. Isoforms of the CD45 common leukocyte antigen family: markers for human T-cell differentiation. J. Clin. Immunol.12:1.
21. Bofill, M., G. Janossy, C.A. Lee, D. MacDonald Burns, A.N. Phillips, C. Sabin, A. Timms, M.A. Johnson, and P.B.A. Kernoff. 1992. Laboratory control values for CD4 and CD8 T lymphocytes. Implications for HIV-1 diagnosis. Clin. Exp Immunol.88:243.
22. Campana, D., E. Coustan-Smith, L. Wong, and G. Janossy. 1989. Expression of T cell receptor associated proteins during human T cell development. Progress in Immunology.7:1276.
23. Pezzella, F., M. Jones, E. Ralfkiaer, J. Ersboll, K.C. Gatter, and D.Y. Mason. 1992. Evaluation of bcl-2 protein expression and 14;18 translocation as prognostic markers in follicular lymphoma. Br. J. Cancer.65:87.
24. Akbar, A.N., L. Terry, A. Timms, P.C. Beverley, and G. Janossy. 1988. Loss of CD45R and gain of UCHL1 reactivity is a feature of primed T cells. J. Immunol.140:2171.
25. Akbar, A.N., P.L. Amlot, K. Ivory, A. Timms, and G. Janossy. 1990. Inhibition of alloresponsive native and memory T cells by CD7 and CD25 antibodies and by Cyclosporin A. Transplantation (Baltimore).50:823.
26. + T cells synergize in response to alloantigens. Eur. J. Immunol.21:2517.
27. Cohen, J.J. 1991. Programmed cell death in the immune system. Adv. Immunol.50:55.
28. Schmid, I., C.H. Uitterbogaart, and J. Giorgi. 1991. A gentle fixation and permeabilization method for combined cell surface and intracellular staining with improved precision in DNA quantification. Cytometry.12:279.
29. Pezzella, F., A.G. Tse, J.L. Cordell, K.A.F. Pulford, K.C. Guter, and D.Y. Mason. 1990. Expression of the Bcl-2 oncogene protein is not specific for the 14;18 chromosome translocation. Am. J. Pathol.137:225.
30. Campana, D., E. Coustan-Smith, A. Manabe, M. Buschle, S.C. Raimondi, F.G. Behm, R. Ashmun, M. Arico, A. Biondi, and C.H. Pui. 1992. Prolonged survival of B-lineage acute lymphoblastic leukemia cells is accompanied by overexpression of bcl-2 protein. Blood.81:1025.
31. Janossy, G., M. Bofill, M. Johnson, and P. Racz. 1991. Changes of germinal center organization in HIV-1 positive lymph nodes. In Accessory Cells in HIV and Other Retroviral Infections. P. Racz, C.D. Dijkstra, and J.C. Gluckman, editors. Karger, Basel. 432-462.
32. Darzynkiewicz, Z., S. Bruno, G. Del Bino, W. Gorczyca, M.A. Hotz, P. Lassota, and F. Traganos. 1992. Features of apoptotic cells measured by cytometry. Cytometry.13:795.
33. Smith, C.A., G.T. Williams, R. Kingston, E.J. Jenkinson, and J.J.T. Owen. 1989. Antibodies to CD3/T cell receptor complex induce death by apoptosis in immature T cells in thymic cultures. Nature (Land.).337:181.
34. Savill, J., I. Dransfield, N. Hogg, and C. Haslett. 1990. Vitronectin receptor-mediated phagocytosis of cells undergoing apoptosis. Nature (Lotid.).343:170.
35. Scott, S., F. Pandolfi, and J.T. Kumick. 1990. Fibroblasts mediate T cell survival: a proposed mechanism for retention of primed T cells. J. Exp. Med.172:1873.
36. + T lymphocytes in Epstein-Barr virus-induced infectious mononucleosis. Blood.80:452.
37. Tomkinson, B.E., D.K. Wagner, D.L. Nelson, and J.L. Sullivan. 1987. Activated lymphocytes during acute Epstein-Barr virus infection. J. Immunol.139:3802.
38. Moss, D.J., C.J. Bishop, S.R. Burrows, and J.M. Ryan. 1985. T lymphocytes in infectious mononucleosis. I. T cell death in vitro. Clin. Exp. Immunol.60:61.
39. Wyllie, A.H. 1987. Apoptosis: cell death in tissue regulation.]. Pathol.153:313.
40. Ling, C.J., W.F.J.R. Owen, and K.F. Austen. 1990. Human fibroblasts maintain the viability and augment the functional response of human neutrophils in culture. J. Clin. Invest.85:601.
41. Owen, W.F., M.E. Rothenberg, D.S. Silberstein, J.C. Gasson, R.L. Stevens, K.F. Austen, and R.J. Soberman. 1987. Regulation of human eosinophil viability, density, and function by granulocyte/macrophage colony-stimulating factor in the presence of 3T3 fibroblasts. J. Exp Med.166:129.
42. Bucala, R., C. Ritchlin, R. Winchester, and A. Cerami. 1991. Constitutive production of inflammatory and mitogenic cytokines by rheumatoid synovial fibroblasts. J. Exp Med. 173:569.
43. Kovacs, E.J. 1991. Fibrogenic cytokines: the role of immune mediators in the development of scar tissue. Immunol. Today. 12:17.
44. Michie, C.A., A. McLean, C. Alcock, and P.C.L. Beverley. 1992. Lifespan of human lymphocyte subsets defined by CD45 isoforms. Nature (Lond.).360:264.
45. Mackay, C.R. 1991. T-cell memory: the connection between function, phenotype and migration pathways. Immunol. Today. 12:189.
46. Gray, D., and P. Matzinger. 1991. T cell memory is short-lived in the absence of antigen. J. Exp Med.174:969.
47. Pitzalis, C., G.H. Kingsley, M. Covelli, R. Meliconi, A. Markey, and G.S. Panayi. 1991. Selective migration of the human helper-inducer memory T cell subset: confirmation by in vivo cellular kinetic studies. Eur. J. Immunol.21:369.