Inhibition of leukocyte adhesion to endothelial cells of human umbilical vein by Y-24180, An antagonist of platelet-activating factor

International Journal of Immunopharmacology

Volumn 15, Issue 6, 1993, Pages 737-744

  Komatsu, Hirotsugu ^a   Nagasawa, Mariko ^a   Okumoto, Takeki ^a  

^a Yoshitomi Pharmaceutical Industries Ltd   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APAFANT; CD18 ANTIGEN; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; ISRAPAFANT; LEUKOTRIENE B4; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST;

ARTICLE; CELL ADHESION; DOSE RESPONSE; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; INFLAMMATORY CELL; NEWBORN; NORMAL HUMAN; PRIORITY JOURNAL;

ANIMAL; ANTIGENS, CD; ANTIGENS, CD18; AZEPINES; CELL ADHESION; CELL ADHESION MOLECULES; CELLS, CULTURED; E-SELECTIN; EDEMA; ENDOTHELIUM, VASCULAR; GUINEA PIGS; HUMAN; INTERCELLULAR ADHESION MOLECULE-1; LEUKOCYTES; MALE; MICE; MICE, INBRED BALB C; PLATELET ACTIVATING FACTOR; TRIAZOLES; UMBILICAL VEINS;

EID: 0027279645     PISSN: 01920561     EISSN: None     Source Type: Journal    
DOI: 10.1016/0192-0561(93)90146-P     Document Type: Article

References (29)

1. Inhibitory effects of the new PAF acether antagonist WEB-2086 on pharmacologic changes induced by PAF inhalation in human beings
2. Endothelial and epithelial cell adhesion molecules
3. The effect of a specific oral PAF-antagonist, MK-287, on antigen-induced early and late asthmatic reactions in man
4. N-(fluorenyl-9-methoxycarbonyl) amino acids, a class of antiinflammatory agents with a different mechanism of action
5. Binding of the integrin Mac-1 (CD11b/CD18) to the third immunoglobulin-like domain of ICAM-1 (CD54) and its regulation by glycosylation
6. The effect of treatment with an oral platelet activating factor antagonist (WEB 2086) on allergen induced asthmatic responses in human subjects
7. A new assay for the measurement of the attachment of neutrophils and other cell types to endothelial cells
8. The role of intercellular adhesion molecule-1 in chronic airway inflammation
9. T lymphocyte adhesion to endothelial cells: mechanisms demonstrated by anti-LFA-1 monoclonal antibodies
10. Effect of potent PAF antagonist, Y-24180, on an allergen-induced late asthmatic response in guinea-pigs
11. Inhibition by cyclo-oxygenase inhibitors of interleukin-6 production by human peripheral blood mononuclear cells
12. Endothelial leukocyte adhesion molecule-1 and intercellular adhesion molecule-1 mediate the adhesion of eosinophils to endothelial cells in vitro and are expressed by endothelium in allergic cutaneous inflammation in vivo
13. IFN-γ regulates the expression of the adhesion molecule ELAM-1 and IL-6 production by human endothelial cells in vitro
14. Regulated expression of the Mac-1, LFA-1, p 150, 95 glycoprotein family during leukocyte differentiation
15. Adhesion molecules and their role in inflammation
16. Selective eosinophil leukocyte recruitment by transendothelial migration and not by leukocyte-endothelial cell adhesion
17. Suppression of the Arthus reaction by Y-24180, a potent and specific antagonist of platelet-activating factor
18. CD43, a molecule defective in Wiskott-Aldrich syndrome, binds ICAM-1
19. Reduced contact sensitivity reactions in mice treated with monoclonal antibodies to leukocyte function-associated molecule-1 and intercellular adhesion molecule-1
20. Purification and partial biochemical characterization of a human monocyte-derived neutrophil-activating peptide that lacks interleukin 1 activity
21. Platelet-activating factor may act as a second messenger in the release of icosanoids and superoxide anions from leukocytes and endothelial cells
22. Neuropeptide Y upregulates the adhesiveness of human endothelial cells for leukocytes
23. Pharmacological actions of Y-24180, a new specific antagonist of platelet activating factor (PAF). II. Interactions with PAF and benzodiazepine receptors
24. Pharmacological actions of Y-24180. I. A potent and specific antagonist of platelet-activating factor
25. Stimulation of neutrophil adherence to vascular endothelial cells by histamine and thrombin and its inhibition by PAF antagonists and dexamethasone
26. Intercellular adhesion molecule-1 (ICAM-1) in the pathogenesis of asthma
27. The mouse ear inflammatory response to topical arachidonic acid
28. Tachyphylaxis in 12-O-tetradecanoylphorbol acetate- and arachidonic acid-induced ear edema
29. Endothelial cell-associated platelet-activating factor: a novel mechanism for signaling intercellular adhesion