Etoposide-induced Apoptosis in Human HL-60 Cells Is Associated with Intracellular Acidification

Cancer Research

Volumn 53, Issue 10, 1993, Pages 2349-2357

  Barry, Michael A ^a   Reynolds, Jason E ^a   Eastman, Alan ^a  

^a DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; DEOXYRIBONUCLEASE II; DNA; ETOPOSIDE;

ACIDIFICATION; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL CYCLE; CELL PH; CELL STRAIN HL 60; DRUG MECHANISM; FLOW CYTOMETRY; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA;

APOPTOSIS; CALCIUM; CELL CYCLE; CELL DEATH; CELL SEPARATION; DNA, NEOPLASM; ENDONUCLEASES; ENZYME ACTIVATION; ETOPOSIDE; FLOW CYTOMETRY; HUMAN; HYDROGEN-ION CONCENTRATION; INTRACELLULAR FLUID; LEUKEMIA, PROMYELOCYTIC, ACUTE; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED;

EID: 0027278822     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: None     Document Type: Article

References (57)

1. Wyllie, A. H. Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation. Nature (Lond.), 284: 555-556, 1980.
2. + T cells in mice tolerant to Staphylococcus aureus enterotoxin B. Nature (Lond.), 349: 245-248, 1991.
3. Rodriguez-Tarduchy, G., Collins, M. and Lopez-Rivas, A. Regulation of apoptosis in interleukin-3-dependent hemopoietic cells by interleukin-3 and calcium ionophores. EMBO J., 9: 2997-3002, 1990.
4. McConkey, D. J., Hartzell, P., Chow, S. C., Orrenius, S. and Jonkal, M. Interleukin 1 inhibits T cell receptor-mediated apoptosis in immature thymocytes. J. Biol. Chem., 265: 3009-3011, 1990.
5. Ucker, D. S. Cytotoxic T lymphocytes and glucocorticoids activate an endogenous suicide process in target cells. Nature (Lond.), 327: 62-64, 1987.
6. Barry, M. A., Behnke, C. A. and Eastman, A. Activation of programmed cell death (apoptosis) by cisplatin, other anticancer drugs, toxins and hyperthermia. Biochem. Pharmacol., 40: 2353-2362, 1990.
7. Lennon, S. V., Martin, S. J. and Cotter, T. G. Dose-dependent induction of apoptosis in human tumour cell lines by widely diverging stimuli. Cell Prolif., 24: 203-214, 1991.
8. Tsujimoto, Y. Stress-response conferred by high level of bcl-2α of protein in human B lymphoblastoid cell. Oncogene, 4: 1331-1336, 1989.
9. Hockenbery, D., Nunez, G., Milliman, C., Schreiber, R. D. and Korsmeyer, S. J. Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature (Lond.), 348: 334-336, 1990.
10. White, E., Sabbatini, P., Debbas, M., Wold, W. S. M., Kusher, D. I. and Gooding, L. R. The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cytolysis by tumor necrosis factor a. Mol. Cell. Biol., 12: 2570-2580, 1992.
11. Gregory, C. D., Dive, C., Henderson, S., Smith, C. A., Williams, G. T., Gordon, J. and Rickinson, A. B. Activation of Epstein-Barr virus latent genes protects human B cells from death by apoptosis. Nature (Lond.), 349: 612-614, 1991.
12. Evan, G. I., Wyllie, A. H., Gilbert, C. S., Littlewood, T. D., Land, H., Brooks, M., Waters, C. M., Penn, L. Z. and Hancock, D. C. Induction of apoptosis in fibroblasts by c-myc protein. Cell, 69: 119-128, 1992.
13. Yonish-Rouach, E., Resnitzky, D., Lotem, J., Sachs, L., Kimchi, A. and Oren, M. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6. Nature (Lond.), 352: 345-347, 1991.
14. Bisonette, R. P., Echeverri, F., Mahboubi, A. and Green, D. R. Apoptotic cell death induced by c-myc is inhibited by bcl-2. Nature (Lond.), 359: 552-554, 1992.
15. Fanidi, A., Harrington, E. A. and Evan, G. I. Cooperative interaction between c-myc and bcl-2 proto-oncogenes. Nature (Lond.), 359: 554-556, 1992.
16. Wyllie, A. H., Kerr, J. E. R. and Currie, A. R. Cell death: the significance of apoptosis. Int. Rev. Cytol., 68: 251-306. 1980.
17. Arrends, M. J., Morris, R. G. and Wyllie, A. H. Apoptosis: the role of the endonuclease. Am. J. Pathol., 136: 593-608, 1990.
18. Eastman, A. and Barry, M. A. The origins of DNA breaks: a consequence of DNA damage, DNA repair or apoptosis. Cancer Invest., 10: 229-240, 1992.
19. Nikonova, L. V., Nelipovich, P. A. and Umansky, S. R. The involvement of nuclear nucleases in rat thymocyte DNA degradation after 7-irradiation. Biochim. Biophys. Acta, 699: 281-289, 1982.
20. 2+-mediated endonuclease activation. Science (Washington DC), 242: 256-259, 1988.
21. McConkey, D. J., Hartzell, P., Nicotera, P. and Orrenius, S. Calcium-activated DNA fragmentation kills immature thymocytes. FASEB J., 3: 1843-1849, 1989.
22. Martikainen, P., Kyprianou, N., Tucker, R. W. and Isaacs, J. T. Programmed cell death of nonproliferating androgen-independent prostatic cancer cells! Cancer Res., 51: 4693-4700. 1991.
23. Ishida, R., Akiyoshi, H. and Takahashi, T. Isolation and purification of calcium and magnesium dependent endonuclease from rat liver nuclei. Biochem. Biophys. Res. Commun., 56: 703-710, 1974.
24. Compton, M. M. and Cidlowski, J. A. Identification of a glucocorticoid-induced nuclease in thymocytes. A potential “lysis gene” product. J. Biol. Chem., 262: 8288-8292, 1987.
25. 2+-dependent nuclease from calf thymus chromatin. Biokhimiya, 54: 1397-1405, 1990.
26. 2+-requiring mechanism. J. Biol. Chem., 265: 17323-17333. 1990.
27. Harmon, B. V., Forster, T. H., Takano, Y. S., Collins, R. J., Gobe, G. C. and Kerr, J. F. R. Cell death induced by hyperthermia: significance of apoptosis. In: J. D. Chapman, W. C., Dewey, and G. F. Whitmore (eds.). Radiation Research: a Twentieth-Century Perspective, Vol. 1, p. 377 (Abstract). New York: Academic Press, 1991.
28. 2+ are not required to trigger apoptosis in human leukaemia cells. Clin. Exp. Immunol., 87: 465-471, 1992.
29. Barry, M. A. and Eastman, A. Identification of deoxyribonuclease II as an endonuclease involved in apoptosis. Arch. Biochem. Biophys., 300: 440-450, 1993.
30. 2+ and pH. Biochem. Biophys. Res. Commun., 186: 782-789, 1992.
31. Cotter, T. G., Lennon, S. V., Glynn, J. M. and Green, D. R. Microfilament-disrupting agents prevent the formation of apoptotic bodies in tumor cells undergoing apoptosis. Cancer Res., 52: 997-1005, 1992.
32. Sorenson, C. M. and Eastman, A. Mechanism of cis-diamminedichloroplatinum(ID-induced cytotoxicity: role of G2 arrest and DNA double-strand breaks. Cancer Res., 48: 4484-4488. 1988.
33. van Erp, P. E. J., Jansen, M. J. J. M. de Jongh, G. J., Boezeman, J. B. M. and Schalkwijk. J. Ratiometric measurement of intracellular pH in cultured human keratinocytes using carboxy-SNARF-1 and flow cytometry. Cytometry, 12: 127-132. 1991.
34. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem., 260: 3440-3450, 1985.
35. Kaufmann, S. H. Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note. Cancer Res., 49: 5870-5878, 1989.
36. Cohen, J. J. and Duke, R. C. Glucorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death. J. Immunol., 132: 38-42, 1984.
37. Del Bino, G. and Darzynkiewicz, Z., Camptothecin, teniposide, or 4′-(9-acridinyl-amino)-3-methanesulfon-m-aniside, but not mitoxantrone or doxorubicin, induces degradation of nuclear DNA in the S phase of HL-60 cells. Cancer Res., 51: 1165-1169, 1991.
38. cdc2 kinase in etoposide-induced cell death of Chinese hamster ovary cells. Cancer Res., 50: 3767-3771, 1990.
39. Habraken, Y. and Verly, W. G. Further purification and characterization of the DNA 3′-phosphatase from rat-liver chromatin which is also a polynucleotide 5′-hyroxyl kinase. Eur. J. Biochem., 171: 59-66. 1988.
40. 2+ pump of the plasma membrane. J. Biol. Chem., 267: 2115? 2118, 1992.
41. Madshus, I. H. Regulation of intracellular pH in eukaryotic cells. Biochem. J., 250: 1-8. 1988.
42. + exchange and metabolism. Am. J. Physiol., 259: C727-C737, 1990.
43. D'Arpa, P., Beardmore, C. and Liu, L. F. Involvement of nucleic acid synthesis in cell killing mechansims of topoisomerase poisons. Cancer Res., 50: 6919-6924, 1990.
44. Eastman, A. Activation of programmed cell death by anticancer agents: cisplatin as a model system. Cancer Cells, 2: 275-280, 1990.
45. Oberhammer, F. A., Pavelka, M., Sharma, S., Tiefenbacher, R., Purchio, A. F., Bursch, W. and Schulte-Hermann, R. Induction of apoptosis in cultured hepatocytes and in regressing liver by transforming growth factor β1. Proc. Natl. Acad. Sci. USA, 89: 5408-5412, 1992.
46. Boe, R., Gjertsen, B. T., Vintermyr, O. K., Houge, G., Lanotte, M. and Doskeland, S. O. The protein phosphatase inhibitor okadaic acid induces morphological changes typical of apoptosis in mammalian cells. Exp. Cell Res., 195: 237-246, 1991.
47. Ucker, D. S., Obermiller, P. S., Eckhart, W., Apgar, J. R., Berger, N. A. and Meyers, J. Genome digestion is a dispensable consequence of physiological cell death mediated by cytotoxic T lymphocytes. Mol. Cell. Biol. 12; 3060-3069, 1992.
48. Blocher, D. and Pohlit, W. DNA double strand breaks in Ehrlich ascites tumour cells at low doses of X-rays. Can cell death be attributed to double strand breaks? Int. J. Radiat. Biol., 42: 329-338, 1982.
49. Allfrey, V. and Mirsky, A. E. Some aspects of the desoxyribonuclease activities of animal tissues. J. Gen. Phys., 36: 227-241, 1952.
50. Harosh, I., Binninger, D. M., Harris, P. V., Mezzina, M. and Boyd, J. B. Mechanism of action of deoxyribonuclease II from human lymphoblasts. Eur. J. Biochem., 202: 479-484. 1991.
51. Yamanaka, M., Tsubota, Y., Anai, M., Ishimatsu, K., Okumura, M., Katsuki, S. and Takagi, Y Purification and properties of acid deoxyribonucleases of human gastric mucosa and cervix uteri. J. Biol. Chem., 249: 3884-3889, 1974.
52. Yasuda, T., Nadano, D., Awazu, S. and Kishi, K. Human urine deoxyribonuclease II (DNase II) isoenzymes: a novel immunoaffinity purification, biochemical multiplicity, genetic heterogeneity and broad distribution among tissues and body fluids. Biochim. Biophys. Acta, 1119: 185-193, 1992.
53. Vorbrodt, A. Cytochemistry of Nuclear Enzymes. In: H. Busch (ed.). The Cell Nucleus, Vol. 3, pp. 309-344. New York: Academic Press, 1974.
54. + antiporter, a glycoprotein of 110 kD. Science (Washington DC), 247: 723-726, 1990.
55. + exchanger is phosphorylated in human platelets in response to activating agents. FEBS Letts., 284: 219-222, 1991.
56. +-ATPases. Nature (Lond.), 352: 347-349, 1991.
57. Gillies, R. J. Martinez-Zaguilan, R., Martinez, G. M., Serrano, R. and Perona, R. Tumorigenic 3T3 cells maintain an alkaline intracellular pH under physiologic conditions. Proc. Natl. Acad. Sci. USA, 87: 7414-7418, 1990.