Nonpeptide Angiotensin II Receptor Antagonists. Synthesis and Biological Activity of Benzimidazoles

Journal of Medicinal Chemistry

Volumn 36, Issue 12, 1993, Pages 1772-1784

  Kubo, Keiji ^a   Inada, Yoshiyuki ^a   Kohara, Yasuhisa ^a   Sugiura, Yoshihiro ^a   Ojima, Mami ^a   Itoh, Katsuhiko ^a   Furukawa, Yoshiyasu ^a   Nishikawa, Kohei ^a   Naka, Takehiko ^a  

^a TAKEDA PHARMACEUTICAL COMPANY LIMITED   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

2 BUTYL 1 [[2' (1H TETRAZOL 5 YL)BIPHENYL 4 YL]METHYL] 1H BENZIMIDAZOLE 7 CARBOXYLIC ACID; ANGIOTENSIN; ANGIOTENSIN RECEPTOR; BENZIMIDAZOLE DERIVATIVE; CV 11194; LOSARTAN; LOSARTAN POTASSIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BLOOD PRESSURE; CONTROLLED STUDY; COW; DOG; DOSE RESPONSE; DRUG ACTIVITY; DRUG SYNTHESIS; HYPERTENSION; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RABBIT; RAT; SPONTANEOUSLY HYPERTENSIVE RAT; STRUCTURE ACTIVITY RELATION;

ADRENAL CORTEX; ANGIOTENSIN II; ANIMAL; AORTA; BENZIMIDAZOLES; BIPHENYL COMPOUNDS; BLOOD PRESSURE; CATTLE; DOGS; IMIDAZOLES; LOSARTAN; MALE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUSCLE CONTRACTION; RABBITS; RATS; RATS, INBRED SHR; RATS, SPRAGUE-DAWLEY; RECEPTORS, ANGIOTENSIN; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLES; X-RAY DIFFRACTION;

EID: 0027276825     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00064a011     Document Type: Article

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