Inhibition of Ca2+-dependent K+ transport and cell dehydration in sickle erythrocytes by clotrimazole and other imidazole derivatives

Journal of Clinical Investigation

Volumn 92, Issue 1, 1993, Pages 520-526

  Brugnara, Carlo ^a   De Franceschi, Lucia ^b   Alper, Seth L ^b  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b NONE

Author keywords

Ca2+ activated channel; Clotrimazole; Erythrocyte; Membrane transport; Sickle cell anemia

Indexed keywords

BUMETANIDE; CALCIMYCIN; CALCIUM ION; CHARYBDOTOXIN; CLOTRIMAZOLE; ECONAZOLE; FLUCONAZOLE; HEMOGLOBIN S; IMIDAZOLE DERIVATIVE; METHAZOLAMIDE; METRONIDAZOLE; MICONAZOLE; NITROIMIDAZOLE DERIVATIVE; ORNIDAZOLE; POTASSIUM CHANNEL; POTASSIUM ION; TINIDAZOLE;

ARTICLE; BINDING AFFINITY; CELL MEMBRANE TRANSPORT; CELL VOLUME; DEHYDRATION; DRUG POTENCY; HUMAN; HUMAN CELL; MEMBRANE PERMEABILITY; MEMBRANE POTENTIAL; ORAL DRUG ADMINISTRATION; POTASSIUM TRANSPORT; PRIORITY JOURNAL; SICKLE CELL; SICKLE CELL ANEMIA;

ANEMIA, SICKLE CELL; BIOLOGICAL TRANSPORT; CALCIUM; CLOTRIMAZOLE; ERYTHROCYTES, ABNORMAL; HUMAN; IMIDAZOLES; IN VITRO; ION CHANNEL GATING; POTASSIUM; POTASSIUM CHANNELS; WATER-ELECTROLYTE BALANCE;

EID: 0027275040     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI116597     Document Type: Article

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