메뉴 건너뛰기




Volumn 178, Issue 1, 1993, Pages 87-99

Interleukln 4 reverses T cell proliferative unresponsiveness and prevents the onset of diabetes in nonobese diabetic mice

Author keywords

[No Author keywords available]

Indexed keywords

CONCANAVALIN A; INTERLEUKIN 4; T LYMPHOCYTE RECEPTOR;

EID: 0027272228     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.178.1.87     Document Type: Article
Times cited : (518)

References (53)
  • 1
    • 0025368646 scopus 로고
    • Role of the T cell receptor in positive and negative selection of developing T cells
    • Blackman, M., J. Kappler, and P. Marrack. 1990. Role of the T cell receptor in positive and negative selection of developing T cells. Science (Wash. DC). 248:1335.
    • (1990) Science (Wash. DC). , vol.248 , pp. 1335
    • Blackman, M.1    Kappler, J.2    Marrack, P.3
  • 2
    • 0025358777 scopus 로고
    • Autoimmune diseases: The failure of self tolerance
    • Sinha, A., C. Lopez, and H.O. McDevitt. 1990. Autoimmune diseases: the failure of self tolerance. Science (Wish. DC). 248:1380.
    • (1990) Science (Wish. DC). , vol.248 , pp. 1380
    • Sinha, A.1    Lopez, C.2    McDevitt, H.O.3
  • 3
    • 0025339511 scopus 로고
    • A cell culture model for T lymphocyte clonal anergy
    • Schwartz, R.H. 1990. A cell culture model for T lymphocyte clonal anergy. Science (Wash. DC). 248:134.
    • (1990) Science (Wash. DC). , vol.248 , pp. 134
    • Schwartz, R.H.1
  • 4
    • 0025309472 scopus 로고
    • Clonal deletion versus clonal anergy: The role of the thymus in inducing self tolerance
    • Ramsdell, F., and B.J. Fowlkes. 1990. Clonal deletion versus clonal anergy: the role of the thymus in inducing self tolerance. Science (Wash. DC). 248:1342.
    • (1990) Science (Wash. DC). , vol.248 , pp. 1342
    • Ramsdell, F.1    Fowlkes, B.J.2
  • 5
    • 0025234628 scopus 로고
    • Type I diabetes: A chronic autoimmune disease of human, mouse, and rat
    • Castano, L., and G.S. Eisenbarth. 1990. Type I diabetes: a chronic autoimmune disease of human, mouse, and rat. Annu. Rev. Immunol. 8:647.
    • (1990) Annu. Rev. Immunol. , vol.8 , pp. 647
    • Castano, L.1    Eisenbarth, G.S.2
  • 6
    • 0025875068 scopus 로고
    • Altered thymic and peripheral T-lymphocyte repertoire precedes the onset of diabetes in NOD mice
    • Zipris, D., A.R. Crow, and T.L. Delovitch. 1991. Altered thymic and peripheral T-lymphocyte repertoire precedes the onset of diabetes in NOD mice. Diabetes. 40:429.
    • (1991) Diabetes , vol.40 , pp. 429
    • Zipris, D.1    Crow, A.R.2    Delovitch, T.L.3
  • 7
    • 0025735437 scopus 로고
    • Defective thymic T cell activation by Con A and anti-CD3 in autoimmune NOD mice. Evidence for thymic T cell anergy that correlates with the onset of insulitis
    • Zipris, D., A.H. Lazarus, A.R. Crow, M. Hadzija, and T.L. Delovitch. 1991. Defective thymic T cell activation by Con A and anti-CD3 in autoimmune NOD mice. Evidence for thymic T cell anergy that correlates with the onset of insulitis. J. Immunol. 146:3763.
    • (1991) J. Immunol. , vol.146 , pp. 3763
    • Zipris, D.1    Lazarus, A.H.2    Crow, A.R.3    Hadzija, M.4    Delovitch, T.L.5
  • 8
    • 85025496918 scopus 로고
    • Altered T cell development and function in prediabetic NOD mice: Mechanism and relevance to disease
    • T. Sasazuki, editor. Oxford University Press. Oxford
    • Rapoport, M.J., D. Zipris, A.H. Lazarus, A. Jaramillo, and T.L. Delovitch. 1991. Altered T cell development and function in prediabetic NOD mice: mechanism and relevance to disease. In HLA 1991. Vol. 2. T. Sasazuki, editor. Oxford University Press. Oxford. 112-121.
    • (1991) HLA 1991 , vol.2 , pp. 112-121
    • Rapoport, M.J.1    Zipris, D.2    Lazarus, A.H.3    Jaramillo, A.4    Delovitch, T.L.5
  • 9
    • 0025791940 scopus 로고
    • Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation
    • DeSilva, D.R., K.B. Urdahl, and M.K. Jenkins. 1991. Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation. J. Immunol. 147:3261.
    • (1991) J. Immunol. , vol.147 , pp. 3261
    • Desilva, D.R.1    Urdahl, K.B.2    Jenkins, M.K.3
  • 10
    • 0026316280 scopus 로고
    • Clonal anergy blocks the response to IL4, as well as the production of IL2, in dual-producing T helper cell clones
    • Mueller, D.L., L. Chiodetti, P.A. Bacon, and R.H. Schwartz. 1991. Clonal anergy blocks the response to IL4, as well as the production of IL2, in dual-producing T helper cell clones. J. Immunol. 147:4118.
    • (1991) J. Immunol. , vol.147 , pp. 4118
    • Mueller, D.L.1    Chiodetti, L.2    Bacon, P.A.3    Schwartz, R.H.4
  • 12
    • 0021984173 scopus 로고
    • Expression of interleukin-2 receptors as a differentiation marker of intrathymic stem cells
    • Ceredig, R., J. Lowenthal, M. Nabholz, and H.R. MacDonald. 1985. Expression of interleukin-2 receptors as a differentiation marker of intrathymic stem cells. Nature (Land.). 314:98.
    • (1985) Nature (Land.). , vol.314 , pp. 98
    • Ceredig, R.1    Lowenthal, J.2    Nabholz, M.3    Macdonald, H.R.4
  • 13
    • 0022529018 scopus 로고
    • Preparation and characterization of a “pan-reactive” rabbit anti-mouse T cell receptor anti-serum
    • Kubo, R.T., and N. Roehm. 1986. Preparation and characterization of a “pan-reactive” rabbit anti-mouse T cell receptor anti-serum. Mol. Immunol. 23:869.
    • (1986) Mol. Immunol. , vol.23 , pp. 869
    • Kubo, R.T.1    Roehm, N.2
  • 15
    • 0021875276 scopus 로고
    • Production of a monoclonal antibody to and molecular characterization of B cell stimulatory factor 1
    • Ohara, J., and W.E. Paul. 1985. Production of a monoclonal antibody to and molecular characterization of B cell stimulatory factor 1. Nature (Lond.). 315:33.
    • (1985) Nature (Lond.). , vol.315 , pp. 33
    • Ohara, J.1    Paul, W.E.2
  • 16
    • 0022640843 scopus 로고
    • Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins
    • Mosmann, T.R., H. Cherwinski, M.W. Bond, M.A. Giedlin, and R.L. Coffman. 1986. Two types of murine helper T cell clone. I. Definition according to profiles of lymphokine activities and secreted proteins. J. Immunol. 136:2348.
    • (1986) J. Immunol. , vol.136 , pp. 2348
    • Mosmann, T.R.1    Cherwinski, H.2    Bond, M.W.3    Giedlin, M.A.4    Coffman, R.L.5
  • 17
    • 0023872192 scopus 로고
    • Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors
    • Karasuyama, H., and F. Melchers. 1988. Establishment of mouse cell lines which constitutively secrete large quantities of interleukin 2, 3, 4 or 5, using modified cDNA expression vectors. Eur. J. Immunol. 18:97.
    • (1988) Eur. J. Immunol. , vol.18 , pp. 97
    • Karasuyama, H.1    Melchers, F.2
  • 18
    • 0025004188 scopus 로고
    • IL-4 production by T cells from naive donors. IL2 is required for IL4 production
    • Ben-Sasson, S.Z., G. Le Gross, D.H. Conrad, F.D. Finkelman, and W.E. Paul. 1990. IL-4 production by T cells from naive donors. IL2 is required for IL4 production. J. Immunol. 145:1127.
    • (1990) J. Immunol. , vol.145 , pp. 1127
    • Ben-Sasson, S.Z.1    Le Gross, G.2    Conrad, D.H.3    Finkelman, F.D.4    Paul, W.E.5
  • 19
    • 0024547146 scopus 로고
    • Derivation of a T cell line that is highly responsive to IL4 and IL2 (CT.4R) and of an IL2 hyporesponsive mutant of that line (CT.4S)
    • Li, J.H., J. Ohara, C. Watson, W. Tsang, and W.E. Paul. 1989. Derivation of a T cell line that is highly responsive to IL4 and IL2 (CT.4R) and of an IL2 hyporesponsive mutant of that line (CT.4S). J. Immunol. 142:800.
    • (1989) J. Immunol. , vol.142 , pp. 800
    • Li, J.H.1    Ohara, J.2    Watson, C.3    Tsang, W.4    Paul, W.E.5
  • 20
    • 0017402665 scopus 로고
    • Long term culture of tumor-specific cytotoxic T cells
    • Gillis, S., and K.A. Smith. 1977. Long term culture of tumor-specific cytotoxic T cells. Nature (Lond.). 268:154.
    • (1977) Nature (Lond.). , vol.268 , pp. 154
    • Gillis, S.1    Smith, K.A.2
  • 21
    • 0021184529 scopus 로고
    • Low and high affinity cellular receptors for interleukin 2. Implications for the level of TAC antigen
    • Robb, R. J. W.C. Greene, and C.M. Rusk. 1984. Low and high affinity cellular receptors for interleukin 2. Implications for the level of TAC antigen. J. Exp. Med. 160:1126.
    • (1984) J. Exp. Med. , pp. 160
    • Robb, R.J.1    Greene, W.C.2    Rusk, C.M.3
  • 22
    • 0023879559 scopus 로고
    • Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies
    • Serreze, D.V., and E.H. Leiter. 1988. Defective activation of T suppressor cell function in nonobese diabetic mice. Potential relation to cytokine deficiencies. J. Immunol. 140:3801.
    • (1988) J. Immunol. , vol.140 , pp. 3801
    • Serreze, D.V.1    Leiter, E.H.2
  • 23
    • 0023907493 scopus 로고
    • Interleukin 2: Inception, impact, and implications
    • Smith, K.A. 1988. Interleukin 2: inception, impact, and implications. Science (Wash. DC). 240:1169.
    • (1988) Science (Wash. DC). , vol.240 , pp. 1169
    • Smith, K.A.1
  • 25
    • 0025006896 scopus 로고
    • Impaired mitogen-induced expression of high-affinity interleukin 2 receptors on spleen cells from NOD/Shi/Kbe mice
    • Hatamori, N., K. Yokono, M. Nagata, K. Shii, and S. Baba. 1990. Impaired mitogen-induced expression of high-affinity interleukin 2 receptors on spleen cells from NOD/Shi/Kbe mice. Diabetes. 39:1070.
    • (1990) Diabetes , vol.39 , pp. 1070
    • Hatamori, N.1    Yokono, K.2    Nagata, M.3    Shii, K.4    Baba, S.5
  • 26
    • 0025320109 scopus 로고
    • Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities
    • Roberts, J.L., S.O. Sharrow, and A. Singer. 1990. Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities. J. Exp Med. 171:935.
    • (1990) J. Exp Med. , vol.171 , pp. 935
    • Roberts, J.L.1    Sharrow, S.O.2    Singer, A.3
  • 27
    • 0025176996 scopus 로고
    • Anti-CD3 antibody induces unresponsiveness to IL2 in Thl clones but not Th2 clones
    • Williams, M.E., A.H. Lichtman, and A.K. Abbas. 1990. Anti-CD3 antibody induces unresponsiveness to IL2 in Thl clones but not Th2 clones. J. Immunol. 144:1208.
    • (1990) J. Immunol. , vol.144 , pp. 1208
    • Williams, M.E.1    Lichtman, A.H.2    Abbas, A.K.3
  • 29
    • 0025248585 scopus 로고
    • IL4 inhibits IL2 receptor expression and IL2 dependent proliferation of human T cells
    • Martinez, C.M., R.C. Gibbons, M.R. Garovoy, and F.R. Aronson. 1990. IL4 inhibits IL2 receptor expression and IL2 dependent proliferation of human T cells. J. Immunol. 144:2211.
    • (1990) J. Immunol , vol.144 , pp. 2211
    • Martinez, C.M.1    Gibbons, R.C.2    Garovoy, M.R.3    Aronson, F.R.4
  • 31
    • 0024353079 scopus 로고
    • Thl and Th2 cells: Different patterns of lymphocyte secretion lead to different functional properties
    • Mossman, T.R., and R.L. Coffman. 1989. Thl and Th2 cells: different patterns of lymphocyte secretion lead to different functional properties. Annu. Rev. Immunol. 7:145.
    • (1989) Annu. Rev. Immunol. , vol.7 , pp. 145
    • Mossman, T.R.1    Coffman, R.L.2
  • 33
    • 0024448693 scopus 로고
    • The genetics of diabetes susceptibility in mice
    • Leiter, E.H. 1989. The genetics of diabetes susceptibility in mice. FASEB (Fed. Am. Soc. Exp Biol.) J. 3:2231.
    • (1989) FASEB (Fed. Am. Soc. Exp Biol.) J. , vol.3 , pp. 2231
    • Leiter, E.H.1
  • 34
    • 0024795364 scopus 로고
    • Im-munostimulation circumvents diabetes in NOD/Lt mice
    • Serreze, D.V., K. Hamaguchi, and E.H. Leiter. 1990. Im-munostimulation circumvents diabetes in NOD/Lt mice. J. Autoimmun. 2:759.
    • (1990) J. Autoimmun. , vol.2 , pp. 759
    • Serreze, D.V.1    Hamaguchi, K.2    Leiter, E.H.3
  • 35
    • 0025971630 scopus 로고
    • T cell antigen receptor activation pathways: The tyrosine kinase connection
    • Klausner, R.D., and L.E. Samelson. 1991. T cell antigen receptor activation pathways: The tyrosine kinase connection. Cell. 64:875.
    • (1991) Cell , vol.64 , pp. 875
    • Klausner, R.D.1    Samelson, L.E.2
  • 36
    • 0025856124 scopus 로고
    • IL4 increases IL2 production by T cells in response to accessory cell-independent stimuli
    • Tanaka, T., S.Z. Ben-Sasson, and W.E. Paul. 1991. IL4 increases IL2 production by T cells in response to accessory cell-independent stimuli. J. Immunol. 146:3831.
    • (1991) J. Immunol. , vol.146 , pp. 3831
    • Tanaka, T.1    Ben-Sasson, S.Z.2    Paul, W.E.3
  • 37
    • 0024507929 scopus 로고
    • Promotion of human T lymphocyte proliferation by IL-4
    • Mitchell, L.C., L.S. Davis, and P.E. Lipsky. 1989. Promotion of human T lymphocyte proliferation by IL-4. J. Immunol. 142:1548.
    • (1989) J. Immunol. , vol.142 , pp. 1548
    • Mitchell, L.C.1    Davis, L.S.2    Lipsky, P.E.3
  • 38
    • 0025300401 scopus 로고
    • A bidirectional regulatory network involving IL-2 and IL4 in the alternative CD2 pathway of T cell activation
    • Lorre, K., J.V. Damme, and J.L. Ceuppens. 1990. A bidirectional regulatory network involving IL-2 and IL4 in the alternative CD2 pathway of T cell activation. Eur. J. Immunol. 20:1569.
    • (1990) Eur. J. Immunol. , vol.20 , pp. 1569
    • Lorre, K.1    Damme, J.V.2    Ceuppens, J.L.3
  • 39
    • 0025082313 scopus 로고
    • Generation of interleukin 4 (IL4)-producing cells in vivo and in vitro: IL2 and IL-4 are required for in vitro generation of IL4 producing cells
    • LeGros, G., S.Z. Ben-Sasson, R. Seder, F.D. Finkelman, and W.E. Paul. 1990. Generation of interleukin 4 (IL4)-producing cells in vivo and in vitro: IL2 and IL-4 are required for in vitro generation of IL4 producing cells. J. Exp Med. 172:921.
    • (1990) J. Exp Med. , vol.172 , pp. 921
    • Legros, G.1    Ben-Sasson, S.Z.2    Seder, R.3    Finkelman, F.D.4    Paul, W.E.5
  • 41
    • 0027509812 scopus 로고
    • Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential
    • + T cell subset that inhibits this autoimmune potential. J. Exp Med. 177:627.
    • (1993) J. Exp Med. , vol.177 , pp. 627
    • Fowell, D.1    Mason, D.2
  • 42
    • 0025761388 scopus 로고
    • T-lympho-cyte changes linked to autoantibodies. Association of insulin autoantibodies with CD4+CD45+ lymphocyte subpopulation in prediabetic subjects
    • + lymphocyte subpopulation in prediabetic subjects. Diabetes. 40:590.
    • (1991) Diabetes , vol.40 , pp. 590
    • Faustman, D.1    Schoenfeld, D.2    Ziegler, R.3
  • 44
    • 0027291701 scopus 로고
    • Altered cytokine activity in adjuvant inhibition of autoimmune diabetes
    • press
    • Shehadeh, N., F. La Rosa, and K.J. Lafferty. 1993. Altered cytokine activity in adjuvant inhibition of autoimmune diabetes. J. Autoimmun. In press.
    • (1993) J. Autoimmun
    • Shehadeh, N.1    La Rosa, F.2    Lafferty, K.J.3
  • 46
    • 0027407564 scopus 로고
    • In vivo role of interleukin 4 in T cell tolerance induced by aqueous protein antigen
    • Burstein, H.J., and A.K. Abbas. 1993. In vivo role of interleukin 4 in T cell tolerance induced by aqueous protein antigen. J. Exp Med. 177:457.
    • (1993) J. Exp Med. , vol.177 , pp. 457
    • Burstein, H.J.1    Abbas, A.K.2
  • 47
    • 0025918156 scopus 로고
    • THO cells in the thymus: The question of T-helper lineages
    • Bendelac, A., and R.H. Schwartz. 1991. THO cells in the thymus: the question of T-helper lineages. Immunol. Rev. 123: 169.
    • (1991) Immunol. Rev. , vol.123 , pp. 169
    • Bendelac, A.1    Schwartz, R.H.2
  • 50
    • 0025020303 scopus 로고
    • Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): Similarities between TNF-a and interleukin 1
    • Jacob, C.O., S. Aiso, A. Michie, H.O. McDevitt, and H. Acha-Orbea. 1990. Prevention of diabetes in nonobese diabetic mice by tumor necrosis factor (TNF): similarities between TNF-a and interleukin 1. Proc. Natl. Acad. Sci. USA. 87:968.
    • (1990) Proc. Natl. Acad. Sci. USA. , vol.87 , pp. 968
    • Jacob, C.O.1    Aiso, S.2    Michie, A.3    McDevitt, H.O.4    Acha-Orbea, H.5
  • 52
    • 0019825716 scopus 로고
    • Interleukin-2 deficiency is a common feature of autoimmune mice
    • Dauphinee, M.J., S.B. Kipper, D. Wofsy, and N. Talal. 1981. Interleukin-2 deficiency is a common feature of autoimmune mice. J. Immunol. 127:2483.
    • (1981) J. Immunol. , vol.127 , pp. 2483
    • Dauphinee, M.J.1    Kipper, S.B.2    Wofsy, D.3    Talal, N.4
  • 53
    • 0021253425 scopus 로고
    • Decreased synthesis of interleukin-2 (IL-2) in insulin-dependent diabetes mellitus
    • Zier, K.S., M.M. Leo, R.S. Spielman, and L. Baker. 1984. Decreased synthesis of interleukin-2 (IL-2) in insulin-dependent diabetes mellitus. Diabetes. 33:552.
    • (1984) Diabetes , vol.33 , pp. 552
    • Zier, K.S.1    Leo, M.M.2    Spielman, R.S.3    Baker, L.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.