Structure-Activity Relationship of N-[2-(Dimethylamino)-6-[3-(5-methyl-4-phenyl-1H-imidazol-1-yl)propoxy]phenyl]-N′-pentylurea and Analogues. Novel Potent Inhibitors of Acyl-CoA:Cholesterol O-Acyltransferase with Antiatherosclerotic Activity

Journal of Medicinal Chemistry

Volumn 36, Issue 11, 1993, Pages 1630-1640

  Kimura, Teiji ^a   Takase, Yasutaka ^a   Hayashi, Kenji ^a   Tanaka, Hiroshi ^a   Ohtsuka, Issei ^a   Saeki, Takao ^a   Kogushi, Motoji ^a   Yamada, Toshie ^a   Fujimori, Tohru ^a   Saitou, Isao ^a   Akasaka, Kozo ^a  

^a EISAI CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACYLTRANSFERASE INHIBITOR; CHOLESTEROL ACYLTRANSFERASE; N [2 (DIMETHYLAMINO) 6 [3 (5 METHYL 4 PHENYL 1H IMIDAZOL 1 YL)PROPOXY]PHENYL] N' PENTYLUREA; N BUTYL N' [2 (DIMETHYLAMINO) 6 [3 (4 PHENYL 1H IMIDAZOL 1 YL)PROPOXY]PHENYL]UREA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; ATHEROSCLEROSIS; CONTROLLED STUDY; DRUG ACTIVITY; DRUG STRUCTURE; ENZYME INHIBITION; HYPERCHOLESTEROLEMIA; INTESTINE; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; STRUCTURE ACTIVITY RELATION;

ANIMAL; ANTICHOLESTEREMIC AGENTS; AORTA; ARTERIOSCLEROSIS; IN VITRO; INTESTINES; MALE; PHENYLUREA COMPOUNDS; RABBITS; RATS; RATS, SPRAGUE-DAWLEY; STEROL O-ACYLTRANSFERASE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0027270448     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00063a013     Document Type: Article

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