NAD(P)H:Quinone oxidoreductase1 (DT-diaphorase) expression in normal and tumor tissues

Cancer and Metastasis Reviews

Volumn 12, Issue 2, 1993, Pages 103-117

  Belinsky, Martin ^a   Jaiswal, Anil K ^a  

^a FOX CHASE CANCER CENTER   (United States)

Author keywords

cancer; cancer chemotherapy; DT diaphorase; expression and induction; normal and tumor tissues; regulation

Indexed keywords

5 (1 AZIRIDINYL) 2,4 DINITROBENZAMIDE; 5 (1 AZIRIDINYL) 3 HYDROXYMETHYL 2 (3 HYDROXY 1 PROPENYL) 1 METHYL 4,7 INDOLEDIONE; AZIRIDINYLBENZOQUINONE; DIAZIQUONE; INDOLOQUINOLINE DERIVATIVE; MITOMYCIN C; NITROIMIDAZOLE DERIVATIVE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); TIRAPAZAMINE;

CANCER CHEMOTHERAPY; CARCINOGENICITY; CELL PROTECTION; DRUG DETOXIFICATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME LOCALIZATION; GENE EXPRESSION REGULATION; HUMAN; MUTAGENICITY; NONHUMAN; OXIDATION REDUCTION REACTION; PRIORITY JOURNAL; REVIEW; TISSUE DISTRIBUTION; TRANSCRIPTION INITIATION;

ANIMAL; ANTINEOPLASTIC AGENTS; BASE SEQUENCE; BREAST; BREAST NEOPLASMS; COLON; COLONIC NEOPLASMS; ENZYME INDUCTION; FEMALE; GENE EXPRESSION; HUMAN; LIVER; LIVER NEOPLASMS; LUNG; LUNG NEOPLASMS; MOLECULAR SEQUENCE DATA; NAD(P)H DEHYDROGENASE (QUINONE); NEOPLASMS; NEOPLASMS, EXPERIMENTAL; OLIGODEOXYRIBONUCLEOTIDES; QUINONES; REFERENCE VALUES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; XENOBIOTICS;

EID: 0027268350     PISSN: 01677659     EISSN: 15737233     Source Type: Journal    
DOI: 10.1007/BF00689804     Document Type: Article

References (80)

1. Soluble diaphorases in animal tissues
2. Purification and some properties of a highly dicoumarol-sensitive liver diaphorase
3. DT-diaphorase: A historical review
4. DT-diaphorase: Properties, reaction mechanism, metabolic function. A progress report
5. Mechanisms of induction of enzymes that protect against chemical carcinogenesis
6. DT-diaphorase and cancer chemotherapy
7. Direct protective effect of NAD(P)H:Quinone Reductase against Menadione-induced chemiluminescence of postmitochondrial fractions of mouse liver
8. Mutagenicity of quinones: pathways of metabolic activation and detoxification
9. Formation of Benzo(a)pyrene-3,6-quinol monoand diglucuronides in rat liver microsomes
10. DT-diaphorase and peroxidase influence the covalent binding of the metabolites of phenol, the major metabolite of benzene
11. The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes
12. Prominent role of DT-diaphorase as a cellular mechanism reducing chromium (VI) and reverting its mutagenicity
13. Possible role of DT-diaphorase in the bioactivation of antitumor quinones
14. Influence of DT-diaphorase on the mutagenicity of organic and inorganic compounds
15. DT-diaphorase
16. DT-diaphorase in morbidly obese patients
17. DT-diaphorase. IV. Coupling of extramitochondrial reduced pyridine nucleotide oxidation to mitochondrial respiratory chain
18. Selective extraction of DT-diaphorase from mitochondria and microsomes
19. Distribution of newly synthesized DT-diaphorase in rat liver
20. Preliminary crystallographic X-ray data for NAD(P)H:quinone reductase from mouse liver
21. The human dioxin-inducible NAD(P)H:quinone oxidoreductase cDNA-encoded protein expressed in COS-1 cells is identical to diaphorase 4
22. Biospecific adsorption of hepatic DT-diaphorase on immobilized dicoumarol
23. Immunochemical studies on two DT-diaphorase active antigens isolated from rat liver cytosol by affinity chromatography
24. Separation and characterization of isoforms of DT-diaphorase from rat liver cytosol
25. Purification and characterization of two isofunctional forms of NAD(P)H:quinone reductase from mouse liver
26. Human FAD-dependent NAD(P)H diaphorase
27. Rat liver NAD(P)H:Quinone reductase
28. NAD(P)H:menadione oxidoreductase: novel purification of enzyme. cDNA and complete aminoacid sequence and gene regulation
29. Human DT-diaphorase, a potential cancer protecting enzyme. Its purification from abdominal adipose tissue
30. Human dioxin-inducible cytosolic NAD(P)H:Quinone Oxidoreductase
31. Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD(P) H:quinone oxidoreductase gene family. Extensive polymorphism at the NQO2 gene locus on chromosome 6
32. Isolation and characterization of DT-diaphorase enzymes from rat liver
33. Identification of glycine-rich sequence as an NAD(P)H-binding site and tyrosine 128 as a dicoumarol-binding site in Rat Liver NAD (P)H:Quinone Oxidoreductase by site-directed Mutagenesis
34. Human NAD(P)H:Quinone Oxidoreductase gene structure and induction by dioxin
35. Rat liver NAD(P)H:Quinone Reductase: regulation of quinone reductase gene expression by planar aromatic compounds and determination of the exon structure of the quinone reductase structural gene
36. The use of DT-diaphorase for the detection of foci of early neoplastic transformation in rat liver
37. The activity of the DT-diaphorase in experimental hepatomas Cancer
38. A constitutive deficiency in the monooxygenase system of spontaneous mouse liver tumors
39. DT-diaphorase activity in various cells in culture with emphasis on induction in ascites hepatoma cells
40. Biochemical and quantitative histochemical study of reduced pyridine nucleotide dehydrogenation by human colon carcinomas
41. Dehydrogenation of reduced pyridine nucleotides by Leydig cell tumors of the rat testis
42. Enzyme histochemical pattern in human tumors-II. Oxidoreductases in carcinoma of the colon and the breast
43. Cytosolic NAD(P)H:(Quinone-Acceptor) Oxidoreductase in human normal and tumor tissue: Effects of cigarette smoking and alcohol
44. High levels of expression of the NAD(P)H:Quinone Oxidoreductase (NQO1) gene in tumor cells compared to normal cells of the same origin
45. The anticancer enzyme DT-diaphorase is induced selectively in liver during Ascites Hepatoma Growth
46. The inhibitory action of methylcholanthrene on rats fed the azo dye 3′-methyl-4-dimethylaminobenzene
47. Genetic differences in induction of cytosol reduced-NAD(P):Menadione Oxidoreductase and microsomal aryl hydrocarbon hydroxylase in the mouse
48. Induction of DT-diaphorase by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCCD)
49. On the mechanism of induction of cancer-protective enzymes: a unifying proposal
50. The regulation of gene expression by 2,3,7,8-tetrachlorodibenzo- p-dioxin
51. P450 genes: structure, evolution and regulation
52. The molecular biology of cytochrome P450s
53. Regulation of mouse CYP1A1 gene expression by dioxin: requirement for two cis-acting elements during induction
54. Genetic and molecular aspects of 2,3,7,8-tetrachlorodibenzo-p-dioxin action
55. Characterization of multiple forms of the Ah receptor: comparison of species and tissues
56. Purification of the Ah receptor from C57BL/6J mouse liver
57. DNA transfection of a gene repressing aryl hydrocarbon hydroxylase induction
58. Role of cytochrome P1-450 in the induction of NAD(P)H:quinone reductase in a murine hepatoma cell line and its mutants
59. Identification of a common chemical signal regulating the induction of enzymes that protect against chemical carcinogenesis
60. Regulation of human NAD(P)H:quinone oxidoreductase gene: role of AP1 binding site contained within human antioxidant response element
61. Identification of Jun-B as third member in human antioxidant response element-nuclear protein complex
62. Transcriptional regulation of the rat NAD(P)H:quinone reductase gene. Identification of regulatory elements controlling basal level expression and inducible expression by planar aromatic compounds and phenolic antioxidants
63. Transcriptional regulation of the rat glutathione S-transferase Ya subunit gene: characterization of a xenobiotic-responsive element controlling inducible expression by phenolic antioxidants
64. Regulation of glutathione S-transferase Ya subunit gene expression: identification of a unique xenobiotic-responsive element controlling inducible expression by planar aromatic compounds
65. The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity
66. Xenobioticinducible expression of murine glutathione S-transferase Ya subunit gene is controlled by an electrophile-responsive element
67. Two adjacent AP-1-like binding sites form the electrophile-responsive element of the murine glutathione S-transferase Ya subunit gene
68. Primary response genes induced by growth factors and tumor promoters
69. Cross-family dimerization of transcription factors Fos/Jun and ATF/CREB alters DNA binding specificity
70. Redox activation of Fos-Jun DNA binding activity is mediated by a DNA repair enzyme
71. Redox redux: The control of oxidative stress responses
72. NAD(P)H:Quinone Oxidoreductase gene expression in human colon carcinoma cells: Characterization of a mutation which modulates DT-diaphorase activity and mitomycin sensitivity
73. Loss of heterozygosity on chromosomal segments 3p, 6q and 11p in human ovarian carcinomas
74. Allelotypes of colorectal carcinomas
75. Allelotype of breast cancer: Cumulative allele losses promote tumor progression in primary breast cancer
76. Rapid detection of inducers of enzymes that protect against carcinogens
77. A major inducer of anticarcinogenic protective enzymes from broccoli: Isolation and elucidation
78. The activation and detoxification of quinones by DT-diaphorase
79. Activation and deactivation of quinones catalyzed by DT-diaphorase. Evidence for bioreductive activation of diaziquone (AZQ) in human tumor cells and detoxification of benzene metabolites in bone marrow stroma