Protective Effect of Hypothermia on Hippocampal Injury After 30 Minutes of Forebrain Ischemia in Rats Is Mediated by Postischemic Recovery of Protein Synthesis

Journal of Neurochemistry

Volumn 61, Issue 1, 1993, Pages 200-209

  Widmann, R ^a   Miyazawa, T ^a   Hossmann, K A ^a  

^a Translational Neurocircuitry Group   (Germany)

Author keywords

Cerebral ischemia; Hippocampus; Hypothermia; Protein synthesis; Rat; Selective vulnerability

Indexed keywords

CARBON 14; LEUCINE;

AMINO ACID BLOOD LEVEL; ANIMAL MODEL; ARTICLE; AUTORADIOGRAPHY; BRAIN BLOOD FLOW; BRAIN ISCHEMIA; BRAIN TEMPERATURE; BRAIN TISSUE; CONTROLLED STUDY; ELECTROENCEPHALOGRAPHY; FOREBRAIN; HIPPOCAMPUS; HISTOPATHOLOGY; HYPOTHERMIA; ISOTOPE LABELING; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RAT;

ANIMAL; AUTORADIOGRAPHY; BRAIN ISCHEMIA; CEREBROVASCULAR CIRCULATION; ELECTROENCEPHALOGRAPHY; HIPPOCAMPUS; HYPOTHERMIA, INDUCED; LEUCINE; MALE; NERVE TISSUE PROTEINS; PROSENCEPHALON; RATS; RATS, WISTAR; REPERFUSION; TEMPERATURE;

ANIMALIA;

EID: 0027267382     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.1993.tb03556.x     Document Type: Article

References (51)

1. Regional impairment of protein synthesis following brief cerebral ischemia in the gerbil
2. Long‐term observations on calcium accumulation in postischemic gerbil brain
3. Cerebral protein synthesis and ischemia
4. Barbiturate promotes post‐ischemic reaggregation of polyribosomes in gerbil hippocampus
5. Changes in protein synthesis in the rabbit spinal cord after ischaemia and recirculation
6. Small differences in inuraischemic brain temperature critically determine the extent of ischemic neuronal injury
7. Effect of mild hypothermia on ischemia‐induced release of neurotransmitters and free fatty acids in rat brain
8. The importance of brain temperature in cerebral ischemic injury
9. Hypothermia prevents the ischemia‐induced translocation and inhibition of protein kinase C in the rat striatum
10. The role of glutamate neurotoxicity in hypoxic‐ischemic neuronal death
11. Effects of ischemia on multifunctional calcium/calmodulin‐dependent protein kinase type II in the gerbil
12. The effect of ischemia and recirculation on protein synthesis in the rat brain
13. Regional brain blood flow, blood volume, and haematocrit values in the adult rat
14. Regional accumulation of calcium in postischemic rat brain
15. Regional protein synthesis in rat brain following acute hemispheric ischemia
16. Calcium in the mitochondria following brief ischemia of gerbil brain
17. Regional cerebral protein synthesis after transient ischemia in the rat. Effect of the AMPA antagonist NBQX
18. Local metabolic responses to cerebral ischemia
19. Measurements of free intracellular and transfer RNA amino acid specific activity and protein synthesis in rat brain in vivo
20. 11C)leucine and PET: methods, model, and results in animals and humans
21. Post‐ischemic resuscitation of the brain: selective vulnerability versus global ischemia
22. Resuscitation potentials after prolonged global cerebral ischemia in cats
23. Disturbances of cerebral protein synthesis and ischemic cell death
24. In vivo cerebral protein synthesis rates with leucyl‐transfer RNA used as a precursor pool: determination of biochemical parameters to structure tracer kinetic models for positron emission tomography
25. Protein synthesis in the cat brain after prolonged cerebral ischemia
26. 3H)tyrosine into cat brain proteins after 1 hour of complete ischemia
27. Resuscitation of the monkey brain after one hour of complete ischemia. III. Indications of metabolic recovery
28. Prevention of postischemic hypothermia prevents ischemic injury of CA, neurons in gerbils
29. Triple‐tracer autoradiography of cerebral flow, glucose utilization, and protein synthesis in rat
30. Ischemic thresholds of cerebral protein synthesis and energy state following middle cerebral artery occlusion in rat
31. The influence of mild body and brain hypothermia on ischemic brain damage
32. Methodological requirements for accurate measurements of brain body temperature during global forebrain ischemia of rat
33. Heating of the brain to maintain “normothermia” aggravates ischemic brain injury of rat
34. A new model of bilateral hemispheric ischemia in the unanesthetized rat
35. The eukaryotic initiation factor 2‐associated 67 kDa polypeptide (p67) plays a role in regulation of protein synthesis initiation in animal cells
36. 2+ homeostasis in the gerbil hippocampus following brief transient ischemia
37. 2+‐dependent protein kinase phosphorylates the beta subunit of eukaryotic initiation factor 2 (eIF‐2)
38. A modified four‐vessel occlusion model for inducing incomplete forebrain ischemia in rats
39. Immunohistochemical study of glial reaction and serum‐protein extravasation in relation to neuronal damage in rat hippocampus after ischemia
40. Historical overview: calcium, ischemia, and death of brain cells
41. Calcium fluxes, calcium antagonists, and calcium‐related pathology in brain ischemia, hypoglycemia, and spreading depression: a unifying hypothesis
42. The measurement of regional rates of cerebral protein synthesis in vivo
43. Measurement of local cerebral protein synthesis in vivo: influence of recycling of amino acids derived from protein degradation
44. Persistent inhibition of protein synthesis precedes delayed neuronal death in postischemic gerbil hippocampus
45. 14C]Leucine incorporation into brain proteins in gerbils after transient ischemia: relationship to selective vulnerability of hippocampus
46. Biochemical and autoradiographical determination of protein synthesis in experimental brain tumors of rat
47. Neuronal damage after repetitive ischemia is preceded by prolonged impairment of protein metabolism
48. Effect of barbiturate treatment on post‐ischemic protein biosynthesis in gerbil brain
49. Effects of a new calcium channel blocker, KB‐2796, on protein synthesis of the CA1 pyramidal cell and delayed neuronal death following transient forebrain ischemia
50. Autoradiographic study of regional protein synthesis in focal cerebral ischemia with TCA wash and image subtraction techniques