Antiplatelet properties of protein S-nitrosothiols derived from nitric oxide and endothelium-derived relaxing factor

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 13, Issue 6, 1993, Pages 791-799

  Simon, Daniel I ^a   Stamler, Jonathan S ^a   Jaraki, Omar ^a   Keaney, John F ^a   Osborne, John A ^a   Francis, Stephanie A ^a   Singel, David J ^a   Loscalzo, Joseph ^a,b  

^a HARVARD UNIVERSITY   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Cyclic GMP; S nitrosothiols; Sulfhydryl groups; Thiols; Thionitrites

Indexed keywords

CYCLIC GMP; ENDOTHELIUM DERIVED RELAXING FACTOR; GUANYLATE CYCLASE; NITRIC OXIDE; PROTEIN S; THIOL DERIVATIVE;

ARTICLE; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME INACTIVATION; NONHUMAN; PRIORITY JOURNAL; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION;

ADENOSINE DIPHOSPHATE; ANIMAL; BLEEDING TIME; BLOOD COAGULATION; BLOOD PLATELETS; BLOOD PROTEINS; COLLAGEN; CYCLIC GMP; CYSTEINE; DOGS; FIBRINOGEN; GLUTATHIONE; HUMAN; MOLECULAR WEIGHT; NITRIC OXIDE; NITROSO COMPOUNDS; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROTEIN BINDING; S-NITROSOGLUTATHIONE; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS;

EID: 0027267083     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.13.6.791     Document Type: Article

References (16)

1. Vanhoutte PM, Rubanyi GM, Miller VM, Houston DS: Modulation of vascular smooth muscle contraction by endothelium. Annu Rev Physiol 1986;48:307-320
2. Radomski MW, Palmer RMJ, Moncada S: The role of nitric oxide and cGMP in platelet adhesion to vascular endothelium. Biochem Biophys Res Commun 1987;148:1482-1489
3. Radomski MW, Palmer RMJ, Moncada S: Endogenous nitric oxide inhibits platelet adhesion to vascular endothelium. Lancet 1987;2:1057-1058
4. Azuma H, Ishikawa M, Sekizaki S: Endothelium-dependent inhibition of platelet aggregation. Br J Pharmacol 1986;88:411-415
5. Furlong B, Henderson AH, Lewis MJ, Smith JA: Endothelium-derived relaxing factor inhibits in vitro platelet aggregation. J Pharmacol 1987;90:687-692
6. Radomski MW, Palmer RMJ, Moncada S: Comparative pharmacology of endothelium-derived relaxing factor, nitric oxide and prostacyclin in platelets. Br J Pharmacol 1987;92:181-187
7. Alheid U, Frolich JC, Forstermann U: Endothelium-derived relaxing factor from cultured human endothelial cells inhibits aggregation of human platelets. Thromb Res 1987;47:561-571
8. Palmer RMJ, Ferrige AG, Moncada S: Nitric oxide release accounts for the biologic activity of endothelium-derived relaxing factor. Nature 1987;327:524-526
9. Ignarro LJ, Buga GM, Wood KS, Byrns RE, Chaudhuri G: Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide. Proc Natl Acad Sci U S A 1987;84: 9265-9269
10. Myers PR, Minor RL, Guerra R, Bates JN, Harrison DG: Vasorelaxant properties of the endothelium-derived relaxing factor more closely resemble S-nitrosocysteine than nitric oxide. Nature 1990; 345:161-163
11. Stamler JS, Simon DI, Osborne JA, Mullins ME, Jaraki O, Michel T, Singel DJ, Loscalzo J: S-Nitrosylation of proteins by nitric oxide: Synthesis and characterization of novel biologically active compounds. Proc Natl Acad Sci U S A 1992;89:444-448
12. Stamler JS, Jaraki O, Osborne J, Simon DI, Keaney J, Vita J, Singel D, Valeri CR, Loscalzo J: Nitric oxide circulates in mammalian plasma primarily as an S-nitroso adduct of serum albumin. Proc Natl Acad Sci USA 1992;89:7674-7677
13. Brown JR: Serum albumin: Amino acid sequence, in Rosenver VM, Oratz M (eds): Albumin Structure, Function, and Uses. Oxford, England, Pergamon Press, 1977, pp 27-51
14. Jocelyn PC: Thiols and disulfides in blood, in Biochemistry of the SH Group. London/New York, Academic Press Inc, 1972, pp 240-260
15. Loscalzo J: A structural and kinetic comparison of recombinant single and two-chain tissue plasminogen activation. J Clin Invest 1988;82:1391-1397
16. Stamler JS, Mendelsohn ME, Amarante P, Smick D, Andon N, Davies PF, Cooke JP, Loscalzo J: N-Acetylcysteine potentiates platelet inhibition by endothelium-derived relaxing factor. Circ Res 1989;65:789-795