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Volumn 34, Issue 37, 1993, Pages 5843-5846

Synthesis of nucleoside α-hydroxy phosphonates

Author keywords

[No Author keywords available]

Indexed keywords

5' O TRITYL 3'BETA HYDROXY 3'ALPHA (O,O DIETHYLPHOSPHONO)THYMIDINE; NUCLEOSIDE DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

EID: 0027258012     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(00)73794-4     Document Type: Article
Times cited : (17)

References (35)
  • 31
    • 85071406078 scopus 로고    scopus 로고
    • General procedure: To a solution of diethylphosphite (1 mmol) in anhydrous THF (1 ml) at −78°C was added dropwise via syringe lithium bis(trimethylsily)amide (2 equiv 1.OM in THF) under a nitrogen atmosphere. After 10 to 15 min, a solution of the keto nucleoside (1 mmol) in 6 ml THF was added, and the reaction mixture was allowed to warm to room temperature over 1.5 h. The reaction was quenched by slow addition of acetic acid in diethyl ether and the resulting mixture was filtered. After concentration in vacuo, the residue was purified by radial chromatography.
  • 34
    • 0026650693 scopus 로고
    • Synthesis of {1-[2′,5′-Bis-O-(t-butyldimethylsilyl)-β-d-xylo- and β-d-ribofuranosyl]thymine}-3′-spiro-5″-{4″-amino-1″,2″-oxathiole-2″,2″-dioxide} (TSAO). A novel type of specific anti-HIV agents
    • (1992) Tetrahedron Letters , vol.33 , pp. 3032
    • Perez-Perez1    San-Felix2    Camarasa3    Balzarini4    De5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.