Comparative Acute Lethality of 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin (TCDD), 1,2,3,7,8‐Pentachlorodibenzo‐p‐dioxin and 1,2,3,4,7,8‐Hexachlorodibenzo‐p‐dioxin in the Most TCDD‐Susceptible and the Most TCDD‐Resistant Rat Strain

Pharmacology & Toxicology

Volumn 73, Issue 1, 1993, Pages 52-56

  Pohjanvirta, Raimo ^a,b   Unkila, Mikko ^a   Tuomisto, Jouko ^a  

^a NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

1,2,3,4,7,8 HEXACHLORODIBENZO 1,4 DIOXIN; 1,2,3,7,8 PENTACHLORODIBENZO 1,4 DIOXIN; 2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; POLYCHLORINATED DIBENZODIOXIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FEMALE; LD 50; MALE; NONHUMAN; RAT; SEX DIFFERENCE; STRAIN DIFFERENCE; TOXICITY;

ANIMAL; BODY WEIGHT; COMPARATIVE STUDY; FEMALE; LETHAL DOSE 50; MALE; RATS; RATS, WISTAR; SEX FACTORS; SUPPORT, NON-U.S. GOV'T; SURVIVAL RATE; TETRACHLORODIBENZODIOXIN;

EID: 0027257203     PISSN: 09019928     EISSN: 16000773     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1993.tb01958.x     Document Type: Article

References (17)

1. Effect of alteration of rat hepatic mixed‐function oxidase (MFO) activity on the toxicity of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD).
2. Dose‐related effects of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) in C57BL/6J and DBA/2J mice.
3. 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin: acute oral toxicity in hamsters.
4. The comparative toxicity of chlorinated dibenzo‐p‐dioxins in mice and guinea pigs.
5. Toxicity of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin in the golden Syrian hamster.
6. TCDD resistance is inherited as an autosomal dominant trait in the rat.
7. Hepatic Ah‐receptor levels and the effect of 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) on hepatic microsomal monooxygenase activities in a TCDD‐susceptible and ‐resistant rat strain.
8. Han/Wistar rats are exceptionally resistant to TCDD. I.
9. 14C‐TCDD in a TCDD‐susceptible and a TCDD‐resistant rat strain.
10. Animal toxicology of chlorinated dibenzo‐p‐dioxins.
11. 2,3,7,8‐Tetrachlorodibenzo‐p‐dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity.
12. Polychlorinated biphenyls (PCBs), dibenzo‐p‐dioxins (PCDDs), dibenzofurans (PCDFs), and related compounds: environmental and mechanistic considerations which support the development of toxic equivalency factors (TEFs).
13. Toxicology of chlorinated dibenzo‐p‐dioxins.
14. Comparative toxicity of four chlorinated dibenzo‐p‐dioxins (CDDs) and their mixture. Part I: Acute toxicity and toxic equivalency factors (TEFs).
15. Acute toxicity of perfluorodecanoic acid and cobalt protoporphyrin in a TCDD‐sensitive and a TCDD‐resistant rat strain.