Antagonism of the five cloned human muscarinic cholinergic receptors expressed in CHO-K1 cells by antidepressants and antihistaminics

Biochemical Pharmacology

Volumn 45, Issue 11, 1993, Pages 2352-2354

  Stanton, Tiffany ^a   Bolden Watson, Carolyn ^a   Cusack, Bernadette ^a   Richelson, Elliott ^a  

^a Departments of Psychiatry and Psychology Pharmacology Mayo Foundation Mayo Clinic JacksonvilleJacksonville ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADINAZOLAM; AMFEBUTAMONE; AMITRIPTYLINE; ANTIDEPRESSANT AGENT; ANTIHISTAMINIC AGENT; CYPROHEPTADINE; DESIPRAMINE; DOSULEPIN; DOXEPIN; ETOPERIDONE; FEMOXETINE; FLUOXETINE; IMIPRAMINE; LOFEPRAMINE; MEQUITAZINE; MUSCARINIC M1 RECEPTOR; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC M5 RECEPTOR; MUSCARINIC RECEPTOR; NORFLUOXETINE; NORSERTRALINE; NORTRIPTYLINE; ORPHENADRINE; PAROXETINE; QUINUCLIDINYL BENZILATE; RADIOLIGAND; RECEPTOR SUBTYPE; SERTRALINE; TRAZODONE; VENLAFAXINE;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DISSOCIATION CONSTANT; HUMAN; LIGAND BINDING; MOLECULAR CLONING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY;

ANIMAL; ANTIDEPRESSIVE AGENTS; CHO CELLS; COMPARATIVE STUDY; CRICETULUS; HAMSTERS; HISTAMINE H1 ANTAGONISTS; HUMAN; MUSCARINIC ANTAGONISTS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027253886     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-2952(93)90211-E     Document Type: Article

References (13)

1. Antidepressants: Pharmacology and clinical use
2. Antidepressants and brain neuro-chemistry
3. Cloning and expression of the human and rat m5 muscarinic acetylcholine receptor genes
4. Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells
5. Antagonism by antimuscarinic and neuroleptic compounds at the five cloned human muscarinic cholinergic receptors expressed in Chinese hamster ovary cel
6. Protein measurement with the Folin phenol reagent
7. A method for radioligand binding assays using a robotic workstation
8. LIGAND: A versatile computerized approach for characterization of ligand-binding systems
9. Log-normal distribution of equieffective doses of norepinephrine and acetylcholine in several tissues
10. Validation and statistical analysis of a computer modeling method for quantitative analysis of radioligand binding data for mixtures of pharmacological
11. Antagonism by anti-depressants of neurotransmitter receptors of normal human brain in vitro
12. Non-selectivity of amitriptyline for subtypes of brain muscarinic receptors demonstrated in binding and functional assays
13. Selective interaction of tricyclic antidepressants with a subclass of rat brain cholinergic muscarinic receptors