Saturation mutagenesis of the human interleukin 6 receptor-binding site: Implications for its three-dimensional structure

Proceedings of the National Academy of Sciences of the United States of America

Volumn 90, Issue 9, 1993, Pages 4067-4071

  Savino, R ^a   Lahm, A ^a   Giorgio, M ^a   Cabibbo, A ^a   Tramontano, A ^a   Ciliberto, G ^a  

^a IRBM   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

BETA INTERFERON; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH HORMONE; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 6; INTERLEUKIN RECEPTOR; MUTANT PROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; BIOASSAY; CHEMICAL STRUCTURE; HEPATOMA CELL; HUMAN; HUMAN CELL; HYBRIDOMA; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN CONFORMATION; RECEPTOR AFFINITY; RECEPTOR BINDING;

AMINO ACID SEQUENCE; ANIMAL; BASE SEQUENCE; BINDING SITES; BIOLOGICAL ASSAY; COMPARATIVE STUDY; CYTOKINES; HUMAN; INTERLEUKIN-6; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, IMMUNOLOGIC; RECEPTORS, INTERLEUKIN-6; SUPPORT, NON-U.S. GOV'T;

EID: 0027252635     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.90.9.4067     Document Type: Article

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