Endothelium-mediated coronary blood flow modulation in humans: Effects of age, atherosclerosis, hypercholesterolemia, and hypertension

Journal of Clinical Investigation

Volumn 92, Issue 2, 1993, Pages 652-662

  Zeiher, Andreas M ^a   Drexler, Helmut ^a   Saurbier, Bemward ^a   Just, Hanjörg ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

Author keywords

Acetylcholine; Coronary artery disease; Coronary vasomotor tone; Endothelium derived relaxing factor; Risk factors

Indexed keywords

ACETYLCHOLINE; CHOLESTEROL; ENDOTHELIUM DERIVED RELAXING FACTOR; PAPAVERINE;

ADULT; AGING; ANGIOCARDIOGRAPHY; ARTICLE; ATHEROSCLEROSIS; BLOOD FLOW VELOCITY; BLOOD VESSEL TONE; CARDIOVASCULAR EFFECT; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DISEASE; CORONARY HEMODYNAMICS; DOSE RESPONSE; FEMALE; HEART LEFT VENTRICLE HYPERTROPHY; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; INTRACORONARY INFUSION; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; VASCULAR ENDOTHELIUM; VASCULAR SMOOTH MUSCLE;

ACETYLCHOLINE; ADULT; AGE FACTORS; ARTERIOSCLEROSIS; BLOOD PRESSURE; CORONARY ANGIOGRAPHY; CORONARY CIRCULATION; CORONARY DISEASE; ENDOTHELIUM, VASCULAR; FEMALE; HEART CATHETERIZATION; HEART RATE; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; MALE; MIDDLE AGE; PAPAVERINE;

EID: 0027249912     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI116634     Document Type: Article

References (69)

1. Vane, R., E. E. Anggard, and R. M. Botting. 1990. Regulatory functions of the vascular endothelium. N. Engl. J. Med. 323:27-36.
2. Furchgott, R. F., and J. V. Zawadzki. 1980. The obligatory role of endotheliai cells in the relaxation of arterial smooth muscle by acetylcholine. Nature (Lond). 288:373-376.
3. Bassenge. E., and R. Busse. 1980. Endothelial modulation of coronary tone. Progr. Cardiovasc. Dis. 30:349-380.
4. Vanhoutte, P. M., G. M. Rubanyi, V. M. Miller, and D. S. Houston. 1986. Modulation of vascular smooth muscle concentration by the endothelium. Annu. Rev. Physiol. 48:307-320.
5. Rapoport, R. M., and F. Murad. 1983. Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP. Circ. Res. 52:352-357.
6. Ignarro, L. J., R. G. Harbison, K. S. Wood, and P. J. Kadowitz. 1986. Activation of purified soluble guanylate cyclase by endothclium-derived relaxing factor from intrapulmonary artery and vein: stimulation by acetylcholine, bradykinin and arachidonic acid. J. Pharmacol. Exp. Ther. 237:893-900.
7. Palmer, R. M., A. G. Ferrige, and S. Moncada. 1987. Nitric oxide accounts for the biological activity of endothelium-derived relaxing factor. Nature (Lond.). 327:524-526.
8. Palmer, R. M., D. S. Ashton, and S. Moncada. 1988. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature (Lond.). 333:664-666.
9. Freiman, P. C., G. C. Mitchell, D. D. Heistad, M. L. Armstrong, and D. G. Harrison. 1986. Atherosclerosis impairs endothelium-dependent vascular relaxation to acetylcholine and thrombin in primates. Circ Res. 58:783-789.
10. Habib, J. B. N., C. Bossaller, S. Wells, C. Williams, J. D. Morrisett, and P. D. Henry. 1986. Preservation of endothelium-dependent vascular relaxation in cholesterol-fed rabbit by treatment with the calcium blocker PN 200110. Circ. Res. 58:305-309.
11. Jayakody, L., M. Senaratne, A. Thomson, and T. Kappagoda. 1987. Endothelium-dependent relaxation in experimental atherosclerosis in the rabbit. Circ. Res. 60:251-264.
12. Bossaler, C., G. B. Habib, H. Yamamoto, C. Williams, S. Wells, and P. D. Henry. 1987. Impaired muscarinic endothelium-dependent relaxation and cyclic guanosine 5-monophosphate formation in atherosclerotic human coronary artery and rabbit aorta. J. Clin. Invest. 79:170-174.
13. Chester, A. H., G. S. O'Neil, S. Moncada, S. Tadjkarimi, and M. H. Yacoub. 1990. Low basal and stimulated release of nitric oxide in atherosclerotic epicardial coronary arteries. Lancet. 336:897-900.
14. Ludmer, P. L., A. P. Selwyn, T. L. Shook, R. R. Wayne, G. H. Mudge, R. W. Alexander, and P. Ganz. 1986. Paradoxical vascoconstriction induced by acetylcholine in atherosclerotic coronary arteries. N. Engl. J. Med. 315:1046-1051.
15. Ross, R. 1986. The pathogenesis of atherosclerosis-an update. N. Engl. J. Med. 314:488-500.
16. Zeiher, A. M., H. Drexler, H. Wollschläger, and H. Just. 1991. Modulation of coronary vasomotor tone. Progressive endothelial dysfunction with different early stages of coronary atherosclerosis. Circulation. 83:391-401.
17. Chilian, W. M., C. L. Eastham, and M. L. Marcus. 1986. Microvascular distribution of coronary vascular resistance in beating left ventricle. Am. J. Physiol. 251:H779-H786.
18. Cannon, R. O., W. H. Schenke, M. B. Leon, D. R. Rosing, J. Urquart, and S. E. Epstein. 1987. Limited coronary flow reserve after dipyridamole in patients with ergonovine-induced coronary vasoconstriction. Circulation. 75:163-174.
19. Juergens, J. L., and P. E. Bernatz. 1980. Atherosclerosis of the extremities. In Peripheral Vascular Diseases. J. L. Juergens, J. A. Spittell, and J. F. Fairbairn II, editors. W. B. Saunders Co., Philadelphia. 253-293.
20. Yamamoto, H., C. Bossaller, J. Cartwright, and P. D. Henry. 1988. Videomicroscopic demonstration of defective cholinergic arteriolar vasodilation in atherosclerotic rabbit. J Clin. Invest. 81:1752-1758.
21. Osborne, J. A., P. H. Lento, M. R. Siegfried, G. L. Stahl, B. Fusman, and A. M. Lefer. 1989. Cardiovascular effects of acute hypercholesterolemia in rabbits. Reversal with lovastatin treatment. J. Clin. Invest 83:465-473.
22. Sellke, F. W., M. L. Armstrong, and D. G. Harrison. 1990. Endotheliumdependent vascular relaxation is abnormal in the coronary microcirculation of atherosclerotic primates. Circulation. 81:1586-1593.
23. Drexler, H., A. M. Zeiher, H. Wollschläger, T. Meinertz, H. Just, and T. Bonzel. 1989. Flow-dependent coronary artery dilatation in humans. Circulation. 80:466-474.
24. Zeiher, A. M., H. Drexler, H. Wollschläger, B. Saurbier, and H. Just. 1989. Coronary vasomotion in response to sympathetic stimulation in humans: importance of the functional integrity of the endothelium. J. Am. Coll. Cardiol. 14:1181-1190.
25. Wollschläger, H., P. Lee, A. M. Zeiher, U. Solzbach, T. Bonzel, and H. Just. 1986. Improvement of quantitative angiography by exact calculation of radiological magnification factors. In Computers in Cardiology 1985. IEEE Computer Society, Washington, D.C. 483-486.
26. Treasure, C. B., J. A. Vita, D. A. Cox, R. Fish, J. B. Gordon, G. H. Mudge, W. S. Colucci, M. G. St. John Sutton, A. P. Selwyn, R. W. Alexander, et al. 1990. Endothelium-dependent dilation of the coronary microvasculature is impaired in dilated cardiomyopathy. Circulation. 81:772-779.
27. Werns, S. W., J. A. Walton, H. H. Hsia, E. G. Nabel, M. L. Sanz, and B. Pitt. 1989. Evidence of endothelial dysfunction in angiographically normal coronary arteries of patients with coronary artery disease. Circulation. 79:287-291.
28. Vita, J. A., C. B. Treasure, E. G. Nabel, J. M. McLenachan, R. D. Fish, A. C. Yeung, V. I. Vekshtein, A. P. Selwyn, and P. Ganz. 1990. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation. 81:491-497.
29. Yasue, H., K. Matsuyama, K. Matsuyama, K. Okumura, Y. Morikami, and H. Ogawa. 1990. Responses of angiographically normal human coronary arteries to intracoronary injection of acetylcholine by age and segment. Circulation. 81:482-490.
30. Tschudi, M., V. Richard, F. R. Bühler, and T. F. Lüscher. 1991. Importance of endothelium-derived nitric oxide in porcine coronary resistance arteries. Am. J. Physiol. 260:H13-H20.
31. Nakayama, K., G. Olsol, and W. Halpern. 1988. Reactivity of isolated porcine coronary resistance arteries to cholinergic and adrenergic drugs and transmural pressure changes. Circ. Res 62:741-748.
32. Myers, P. R., P. F. Banitt, R. Guerra, and D. G. Harrison. 1989. Characteristics of canine coronary resistance arteries: importance of endothelium. Am. J. Physiol. 257:H603-H610.
33. Dohi, Y., M. A. Thiel, F. R. Bühler, and T. F. Luscher. 1990. Activation of endothelial L-arginine pathway in resistance arteries. Effect of age and hypertension. Hypertension (Dallas). 15:170-179.
34. Stewart, D., T. Munzel, and E. Bassenge. 1987. Reversal of acetylcholine-induced coronary resistance vessel dilation by hemoglobin. Eur. J. Pharmacol. 136:239-242.
35. Hodgson, J. Mc. B., and J. Marshall. 1989. Direct vasoconstriction and endothelium-dependent vasodilation. Mechanisms of acetylcholine effects on coronary now and arterial diameter in patients with nonstenotic coronary arteries. Circulation. 79:1043-1051.
36. Linder, L., W. Kiowski, F. R. Bühler, and T. Luscher. 1990. Indirect evidence for release of endothelium-derived relaxing factor in human forearm circulation in vivo. Blunted response in essential hypertension. Circulation. 81:1762-1767.
37. Panza, J. A., A. A. Quyyumi, J. E. Brush, and S. E. Epstein. 1990. Abnormal endothelium-dependent vascular relaxation in patients with essential hypertension. N. Engl. J. Med. 323:22-27.
38. Creager, M. A., J. P. Cooke, M. E. Mendelsohn, S. J. Gallagher, S. M. Coleman, J. Loscalzo, and V. J. Dzau. 1990. Impaired vasodilation of forearm resistance vessels in hypercholesterolemic humans. J. Clin. Invest. 86:228-234.
39. Feletou, M., and P. M. Vanhoute. 1988. Endothelium-dependent hyperpolarization of canine coronary smooth muscle. Br. J. Pharmacol. 93:515-524.
40. Yanigasawa, M., H. Kurihara, S. Kimura, Y. Tomobe, M. Kobayashi, Y. Mitsui, Y. Yazaki, K. Goto, and T. Masaki. 1988. A novel potent vasoconstrictor peptide produced by vascular endothelial cells. Nature (Lond.). 332:411-415.
41. Cooke, J. P., E. Rossitch, Jr., N. A. Andon, J. Loscalzo, and V. J. Dzau. 1991. Flow activates an endothelial potassium channel to release an endogenous nitrovasodilator. J. Clin. Invest. 88:1663-1671.
42. Cooke, J. P., J. S. Stamler, N. Andon, P. R. Davies, and J. Loscalzo. 1990. Flow stimulates endothelial cells to release a nitrovasodilator that is potentiated by reduced thiol. Am. J. Physiol. (Heart Circ. Physiol.) 28:H804-H812.
43. Frangos, J. A., S. G. Eskin, L. V. Mclntire, and C. L. Ives. 1984. Flow effects on prostacyclin production by cultured human endothelial cells. Science (Wash. DC). 227:1477-1479.
44. Newman, C. M., D. R. Hackett, M. Fryer, H. M. El-Tamini, G. J. Davies, and A. Maseri. 1987. Dual effects of acetylcholine on angiographically normal coronary arteries in vivo. Circulation. 76(Suppl. IV):IV-238. (Abstr.)
45. Merkel, L. A., L. M. Rivera, E. Glenda, and M. H. Perrone. 1990. Differential alteration of vascular reactivity in rabbit aorta with modest elevation of serum cholesterol. Circ. Res. 67:550-555.
46. Osborne, J. A., M. J. Siegman, A. W. Sedar, S. U. Mooers, and A. M. Lefer. 1989. Lack of endothelium-dependent relaxation in coronary resistance arteries of cholesterol-fed rabbits. Am. J. Physiol. 256:C591-C597.
47. Tanner, F. C., G. Noll, C. M. Boulanger, and T. F. Lüscher. 1991. Oxidized low density lipoproteins inhibit relaxations of porcine coronary arteries. Role of scavenger receptor and endothelium-derived nitric oxide. Circulation. 83:2012-2020.
48. Rossitch, Jr., E., E. M. Alexander III, P. Black, and J. P. Cooke. 1991. L-arginine normalizes endothelial function in cerebral vessels from hypercholesterolemic rabbits. J. Clin. Invest. 87:1295-1299.
49. Girerd, X. J., A. T. Hirsch, J. P. Cooke, V. J. Dzau, and M. A. Creager. 1990. L-arginine augments endothelium-dependent vasodilation in cholesterolfed rabbits. Circ. Res. 67:1301-1308.
50. Drexler, H., A. M. Zeiher, K. Meinzer, and H. Just. 1991. Correction of endothelial dysfunction in coronary microcirculation of hypercholesterolemic patients by L-arginine. Lancet. 338:1546-1550.
51. Dzau, V. J., and M. E. Safar. 1988. Large conduit arteries in hypertension: role of the vascular renin-angiotensin system. Circulation. 77:947-954.
52. Zeiher, A. M., and H. Drexler. 1990. Coronary hemodynamic determinants of epicardial artery vasomotor responses during sympathetic stimulation in humans. Basic Res Cordial. 86(Suppl II):203-213.
53. Roberts, W. C. 1980. The hypertensive diseases. In Topics in Hypertension. J. H. Laragh, editor. Yorke Medical Books, New York. 368-388.
54. Eggen, D. A., and L. A. Solberg. 1968. Variation of atherosclerosis with age. Lab. Invest. 18:111-119.
55. Stary, H. C. 1989. Evolution and progression of atherosclerotic lesions in coronary arteries of children and young adults. Arteriosclerosis. 9(Suppl I):I-19-I-32.
56. Stewart, P. A., M. Magliocco, K. Hayakawa, C. L. Farrell, F. R. Del Maestro, J. Girvin, J. C. E. Kaufmann, H. V. Vinters, and J. Gilbert. 1987. A quantitative analysis of blood-brain barrier ultrastructure in the aging human. Microvasc. Res. 33:270-282.
57. Mayhan, W. G., F. M. Faraci, G. L. Baumbach, and D. D. Heistad. 1990. Effects of aging on responses of cerebral arterioles. Am. J. Physiol. 258:H1138-H1143.
58. Schnider, S. L., and R. R. Kohn. 1980. Glucosylation of human collagen in aging and diabetes mellitus. J. Clin. Invest. 66:1179-1181.
59. Bucala, R., K. J. Tracey, and A. Cerami. 1991. Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilation in experimental diabetes. J. Clin. Invest. 87:432-438.
60. Marcus, M. L., W. M. Chilian, H. Kanatsuka, K. C. Dellsperger, C. L. Eastham, and K. G. Lamping. 1990. Understanding the coronary circulation through studies at the microvascular level. Circulation. 82:1-7.
61. Vallance, P., J. Collier, and S. Moncada. 1989. Effects of endothelium-derived nitric oxide on peripheral arteriolar tone in man. Lancet. 2:997-1000.
62. Kurz, M. A., K. G. Lamping, J. N. Bates, C. L. Eastham, M. L. Marcus, and D. G. Harrison. 1991. Mechanisms responsible for the heterogeneous coronary microvascular response to nitroglycerin. Circ. Res. 68:847-855.
63. Zeiher, A. M., H. Drexler, H. Wollschläger, and H. Just. 1991. Endothelial dysfunction of the coronary microvasculature is associated with impaired coronary blood flow regulation in patients with early atherosclerosis. Circulation. 84:1984-1992.
64. Zeiher, A. M., V. Schachinger, S. H. Weitzel, H. Wollschläger, and H. Just. 1991. Intracoronary thrombus formation causes focal vasoconstriction of epicardial arteries in patients with coronary artery disease. Circulation. 83:1519-1525.
65. McFadden, E. P., J. G. Clarke, G. J. Davies, J. C. Kaski, A. W. Haider, and A. Maseri. 1991. Effect of intracoronary serotonin on coronary vessels in patients with stable angina and patients with variant angina. N. Engl. J. Med. 324:648-654.
66. Golino, P., F. Piscione, J. T. Willerson, M. Cappelli-Bigazzi, A. Focaccio, B. Villari, C. Indolfi, E. Russolillo, M. Condorelli, and M. Chiariello. 1991. Divergent effects of serotonin on coronary-artery dimensions and blood flow in patients with coronary atherosclerosis and control patients. N. Engl. J. Med. 324:641-648.
67. Sakamoto, S., M. Kashiki, N. Imai, C. Liang, and W. B. Hood, Jr. 1991. Effects of short-term, diet-induced hypercholesterolemia on systemic hemodynamics, myocardial blood flow, and infarct size in awake dogs with acute myocardial infarction. Circulation. 84:378-386.
68. Tilton, R. P., P. A. Cole, J. D. Zions, A. Daugherty, K. B. Larson, S. P. Sutera, C. Kilo, and J. R. Williamson. 1987. Increased ischemia-reperfusion injury to the heart associated with short-term, diet-induced hypercholesterolemia in rabbits. Circ. Res. 60:551-559.
69. Berk, B. C. 1991. The microcirculation in coronary ischemia. Circulation. 84:439-441.