A low dose euglycemic infusion of recombinant human insulin-like growth factor I rapidly suppresses fasting-enhanced pulsatile growth hormone secretion in humans

Journal of Clinical Investigation

Volumn 91, Issue 6, 1993, Pages 2453-2462

  Hartman, Mark L ^a   Clayton, Peter E ^a   Johnson, Michael L ^a   Celniker, Abbie ^b   Perlman, Andrew J ^b   Alberti, K G M M ^c   Thorner, Michael O ^a  

^a UNIVERSITY OF VIRGINIA HEALTH SYSTEM   (United States)

^b GENENTECH INC   (United States)

^c NEWCASTLE UNIVERSITY   (United Kingdom)

Author keywords

Deconvolution; Glucagon; Insulin; Metabolism; Pituitary gland

Indexed keywords

3 HYDROXYBUTYRIC ACID; ACETOACETIC ACID; FATTY ACID; GLUCAGON; GROWTH HORMONE; INSULIN; RECOMBINANT SOMATOMEDIN C; SOMATOMEDIN C RECEPTOR;

ADULT; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; FATTY ACID BLOOD LEVEL; GLUCAGON BLOOD LEVEL; GLUCOSE INFUSION; GROWTH HORMONE RELEASE; HALF LIFE TIME; HUMAN; HUMAN EXPERIMENT; INSULIN BLOOD LEVEL; INTRAVENOUS DRUG ADMINISTRATION; MALE; NORMAL HUMAN; PRIORITY JOURNAL; PULSATILE HORMONE RELEASE;

3-HYDROXYBUTYRIC ACID; ACETOACETATES; ADULT; BIOLOGICAL TRANSPORT, ACTIVE; FASTING; FATTY ACIDS; GLUCAGON; GLUCOSE CLAMP TECHNIQUE; GROWTH HORMONE; HUMAN; HYDROXYBUTYRATES; INSULIN; INSULIN-LIKE GROWTH FACTOR I; MALE; PERIODICITY; RECOMBINANT PROTEINS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027247493     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI116480     Document Type: Article

References (60)

1. Daughaday, W. H., and P. Rotwein. 1989. Insulin-like growth factors I and II. Peptide. messenger ribonucleic acid and gene structures, serum, and tissue concentrations. Endocr. Rev. 10:68-91.
2. Lowe, Jr., W. L. 1991. Biological actions of the insulin-like growth factors. In Insulin-like Growth Factors: Molecular and Cellular Aspects. D. LeRoith, editor. CRC Press, Boca Raton, FL. 49-85.
3. Clemmons, D. R. 1991. Insulin-like growth factor binding proteins. In Insulin-like Growth Factors: Molecular and Cellular Aspects. D. LeRoith, editor. CRC Press, Boca Raton, FL. 151-179.
4. Casanueva, F. F. 1992. Physiology of growth hormone secretion and action. Endocrinol. Metab. Clin. North Am. 21:483-517.
5. Tannenbaum G. S. 1989. Interrelation of growth hormone-releasing hormone and somatostatin in the regulation of growth hormone secretion. In Hormonal Regulation of Growth. H. Frisch and M. O. Thorner, editors. Raven Press, New York. 1-17.
6. Frohman, L. A., T. R. Downs, I. J. Clarke, and G. B. Thomas. 1990. Measurement of growth hormone-releasing hormone and somatostatin in hypothalamic-portal plasma of unanesthetized sheep: spontaneous secretion and response to insulin-induced hypoglycemia. J. Clin. Invest. 86:17-24.
7. Thorner, M. O., M. L. Vance, M. L. Hartman, R. W. Holl, W. S. Evans, J. D. Veldhuis, E. Van Cauter, G. Copinschi, and C. Y. Bowers. 1990. Physiological role of somatostatin on growth hormone regulation in humans. Metab. Clin. Exp. 39 (Suppl 2):40-42.
8. Hartman, M. L., A. C. S. Faria, M. L. Vance, M. L. Johnson, M. O. Thorner, and J. D. Veldhuis. 1991. Temporal structure of in vivo growth hormone secretory events in humans. Am. J. Physiol. 260:E101-E110.
9. Tannenbaum, G. S., H. J. Guyda, and B. I. Posner. 1983. Insulin-like growth factors: a role in growth hormone negative feedback and body weight regulation via brain. Science (Wash. DC). 220:77-79.
10. Abe, H., M. E. Molitch, J. J. Van Wyk, and L. E. Underwood. 1983. Human growth hormone and somatomedin-C suppress the spontaneous release of growth hormone in unanesthetized rats. Endocrinology. 113:1319-1324.
11. Harel, Z., and G. S. Tannenbaum. 1992. Synergistic interaction between insulin-like growth factors-I and -II in central regulation of pulsatile growth hormone secretion. Endocrinology. 131:758-764.
12. Yamashita, S., and S. Melmed. 1986. Insulin-like growth factor I action on rat anterior pituitary cells: suppression of growth hormone secretion and messenger ribonucleic acid levels. Endocrinology. 118:176-182.
13. Berelowitz, M., M. Szabo, L. A. Frohman, S. Firestone, L. Chu, and R. L. Hintz. 1981. Somatomedin-C mediates growth hormone negative feedback by effects on both the hypothalamus and the pituitary. Science (Wash. DC). 212:1279-1281.
14. Aquila, M. C. 1991. Insulin-like growth factor I (IGF-I) regulates somatostatin (SRIF) release, messenger ribonucleic acid levels in the rat hypothalamus. Prog. 73rd Meet. Endocr. Soc. 351. (Abstr. 1283).
15. Shibasaki, T., N. Yamauchi, M. Hotta, A. Masuda, T. Imaki, H. Demura, N. Ling, and K. Shizume. 1986. In vitro release of growth hormone-releasing factor from rat hypothalamus: effect of insulin-like growth factor-I. Regul. Pept. 15:47-53.
16. Sato, M., and L. A. Frohman. 1992. Differential effects of central and peripheral administration of GH and IGF-I on hypothalamic GH-releasing hormone (GRH) and somatostatin (SRIH) gene expression in the GH-deficient dwarf (dw) rat. Prog. 74th Meet. Endocr. Soc. 446. (Abstr. 1580).
17. Guler, H.-P., J. Zapf, and E. R. Froesch. 1987. Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults. N. Engl. J. Med. 317:137-140.
18. Guler, H.-P., C. Schmid, J. Zapf, and E. R. Froesch, 1989. Effects of recombinant insulin-like growth factor I on insulin secretion and renal function in normal human subjects. Proc. Natl. Acad. Sci. USA. 86:2868-2872.
19. Zenobi, P. D., S. Graf, H. Ursprung, and E. R. Froeseh, 1992. Effects of insulin-like growth factor I on glucose tolerance, insulin levels, and insulin secretion. J. Clin. Invest. 89:1908-1913.
20. DeFronzo, R. A., J. D. Tobin, and R. Andres. 1979. Glucose clamp technique: a method for quantifying insulin secretion and resistance. Am. J. Physiol. 237:E214-E223.
21. Ho, K. Y., J. D. Veldhuis, M. L. Johnson, R. Furlanetto, W. S. Evans, K. G. M. M. Alberti, and M. O. Thorner. 1988. Fasting enhances growth hormone secretion and amplifies the complex rhythms of growth hormone secretion in man. J. Clin. Invest. 81:968-975.
22. Hartman, M. L., J. D. Veldhuis, M. L. Johnson, M. M. Lee, K. G. M. M. Alberti, E. Samojlik, and M. O. Thorner. 1992. Augmented growth hormone (GH) secretory burst frequency and amplitude mediate enhanced GH secretion during a two day fast in normal men. J. Clin. Endocrinol Metab. 74:757-765.
23. Veldhuis, J. D., and M. L. Johnson. 1992. Deconvolution analysis of hormone data. Methods Enzymol. 210:539-575.
24. Lieberman S. A., J. Bukar, S. A. Chen, A. C. Celniker, P. G. Compton, J. Cook, J. Albu, A. J. Perlman, and A. R. Huffman. 1992. Effects of recombinant human insulin-like growth factor-I (rhIGF-1) on total and free IGF-I concentrations. IGF-binding proteins, and glycemic response in humans. J. Clin. Endocrinol. Metab. 75:30-36.
25. Daughaday, W. H., I. K. Mariz, and S. L. Blethen. 1980. Inhibition of access of bound somatomedin to membrane receptor and immunobinding sites: a comparison of radioreceptor and radioimmunoassay of somatomedin in native and acid-ethanol-extracted serum. J. Clin. Endocrinol. Metab. 51:781-788.
26. Freedlender, A. E., G. E. Vandenhoff, M. S. MacLeod, and R. R. Malcolm. 1984. Radioimmunoassay of insulin. In Methods in Diabetes Research. Vol. 1B. J. Larner and S. L. Pohl, editors. John Wiley & Sons, New York. 295-305.
27. Von Schenck, H. 1984. Radioimmunoassay of glucagon. In Methods in Diabetes Research. Vol. 1B. J. Larner and S. L. Pohl, editors. John Wiley & Sons. New York. 327-345.
28. Harrison, J., A. W. Hodson, A. W. Skillen, R. Stappenbeck, L. Agius, and K. G. M. M. Alberti. 1988. Blood glucose, lactale, pyruvate, 3-hydroxybutyrate and acetoacetate measurements in man using a centrifugal analyzer with fluorimetric attachment. J. Clin. Chem. din. Biochem. 26:141-146.
29. Knox, D. P., and D. G. Jones. 1984. Automated enzymatic determination of plasma free fatty acids by centrifugal analysis. J. Automatic Chem. 6:152-154.
30. Hartman, M. L., J. D. Veldhuis, M. L. Vance, A. C. S. Faria, R. W. Furlanetto, and M. O. Thorner. 1990. Somatotropin pulse frequency and basal concentrations are increased in acromegaly and are reduced by successful therapy. J. Clin. Endocrinol. Metab. 70:1375-1384.
31. Faria, A. S. C., J. D. Veldhuis, M. O. Thorner, and M. L. Vance. 1989. Half-time of endogenous growth hormone (GH) disappearance in normal man after stimulation of GH secretion by GH-releasing hormone and suppression with somatostatin. J. Clin. Endocrinol. Metab. 68:535-541.
32. Johnson, M. L., and S. G. Frazier. 1985. Non-linear least-squares analysis. Methods Enzymol. 117:301-342.
33. Daniel, W. W. 1987. Biostatistics: A Foundation for Analysis in the Health Sciences. John Wiley & Sons, New York.
34. O'Brien, P. C., and M. A. Shampo. 1988. Statistical considerations for performing multiple tests in a single experiment. 3. Repeated measures overtime. Mayo Clin. Proc. 63:918-920.
35. Hoeffler, J. P., S. A. Hicks, and S. L. Frawley. 1987. Existence of somatotrope subpopulations which are differentially responsive to insulin-like growth factor I and somatostatin. Endocrinology. 120:1936-1941.
36. Ceda, G. P., R. G. Davis, R. G. Rosenfeld, and A. R. Hoffman. 1987. The growth hormone (GH)-releasing hormone (GHRH)-GH-somatostatin axis: evidence for rapid inhibition of GHRH-elicited GH release by insulin-like growth factors I and II. Endocrinology. 120:1658-1662.
37. Lamberts, S. W. J., F. Den Holder, and L. J. Hofland. 1989. The interrelationship between the effects of insulin-like growth factor I and somatostatin on growth hormone secretion by normal rat pituitary cells: the role of glucocorticoids. Endocrinology. 124:905-911.
38. Namba H., S. Morita, and S. Melmed. 1989. Insulin-like growth factor-I action on growth hormone secretion and messenger ribonucleic acid levels: interaction with somatostatin. Endocrinology. 124:1794-1799.
39. Winer, L. M., M. A. Shaw, and G. Baumann. 1990. Basal plasma growth hormone levels in man: new evidence for rhythmicity of growth hormone secretion. J. Clin. Endocrinol. Metab. 70:1678-1686.
40. Rosenfeld, R. G., G. Ceda, D. M. Wilson, L. A. Dollar, and A. R. Hoffman. 1984. Characterization of high affinity receptors for insulin-like growth factors I and II on rat anterior pituitary cells. Endocrinology. 114:1571-1575.
41. Werner, H., M. Woloschak, B. Stannard, Z. Shen-Orr, C. T. Roberts, Jr., and D. LeRoith. 1991. The insulin-like growth factor I receptor: molecular biology, heterogeneity, and regulation. In Insulin-like Growth Factors: Molecular and Cellular Aspects. D. LeRoith, editor. CRC Press. Boca Raton, FL. 17-47.
42. Zapf, J., C. Schmid, H. P. Guler, M. Waldvogel, C. Hauri, P. Hossenlopp, M. Binoux, and E. R. Froesch. 1990. Regulation of binding proteins for insulin-like growth factors (IGF) in humans: increased expression of IGF binding protein 2 during IGF I treatment of healthy adults and in patients with extrapancreatic tumor hypoglycemia. J. Clin. Invest. 86:952-961.
43. Young, S. C. J., L. E. Underwood, A. Celniker, and D. R. Clemmons. 1992. Effects of recombinant insulin-like growth factor-I (IGF-I) and growth hormone on serum IGF-binding proteins in calorically restricted adults. J. Clin. Endocrinol. Metab. 75:603-608.
44. Bar, R. S., M. Boes, D. R. Clemmons, W. H. Busby, A. Sandra, B. L. Dake, and B. A. Booth. 1990. Insulin differentially alters transcapillary movement of intravascular IGFBP-1, IGFBP-2 and endothelial cell IGF-binding proteins in the rat heart. Endocrinology. 127:497-499.
45. Clemmons, D. R., A. Smith-Banks, and L. E. Underwood. 1992. Reversal of diet-induced catabolism by infusion of recombinant insulin-like growth factor-I in humans. J. Clin. Endocrinol. Metab. 75:234-238.
46. Takano, K., N. Hizuka, K. Shizume, K. Asakawa, I. Fukuda, and H. Demura. 1991. Repeated sc administration of recombinant human insulin-like growth factor I (IGF-I) to human subjects for 7 days. Growth Regul 1:23-28.
47. Boulware, S. D., N. J. Rennert, L. S. Matthews, W. V. Tamborlane, and R. S. Sherwin. 1991. The scope of IGF-I's actions in humans extend to carbohydrate, protein and lipid metabolism. Prog. 73rd Meet. Endocr. Soc. 434. (Abstr. 1613).
48. Dohm, G. L., C. W. Elton, M. S. Raju, N. D. Mooney, R. DiMarchi, W. J. Pories, E. G. Flickinger, S. M. Atkinson, and J. F. Caro. 1990. IGF-I-stimulated glucose transport in human skeletal muscle and IGF-I resistance in obesity and NIDDM. Diabetes. 39:1028-1032.
49. Hartman, M. L., and P. E. Clayton. 1992. IGF-I suppression of pulsatile GH secretion is not mediated by glucose uptake in man. Prog. 74th Meet. Endocr. Soc. 321. (Abstr. 1080).
50. Press, M., S. Caprio, W. V. Tamborlane, R. Bhushan, M. Thorner, W. Vale, J. Rivier, and R. S. Sherwin. 1992. Pituitary responses to growth hormone-releasing hormone in IDDM: abnormal responses to insulin and hyperglycemia. Diabetes. 41:17-21.
51. Van Schravendijk, C. F. H., A. Foriers, J. L. Van den Brande, and D. G. Pipeleers. 1987. Evidence for the presence of type 1 insulin-like growth factor receptors on rat pancreatic A and B cells. Endocrinology. 121:1784-1788.
52. Otonkoski, T., M. Knip, I. Wong, and O. Simell. 1988. Effects of growth hormone and insulin-like growth factor I on endocrine function of human fetal islet-like cell clusters during long-term tissue culture. Diabetes. 37:1678-1683.
53. Kawai, K., S. Suzuki, K. Takano, N. Hizuka, Y. Watanabe, and K. Yamashita. 1990. Effects of insulin-like growth factor-I on insulin and glucagon release from isolated perfused rat pancreas. Endocrinol. J. 37:867-874.
54. Leahy, J. L., and K. M. Vandekerkhove. 1990. Insulin-like growth factor-I at physiological concentration is a potent inhibitor of insulin secretion. Endocrinology. 126:1593-1598.
55. Zapf, J., C. Hauri, M. Waldvogel, and E. R. Froesch. 1986. Acute metabolic effects and half-lives of intravenously administered insulin-like growth factors I and II in normal and hypophysectomized rats. J. Clin. Invest. 77:1768-1775.
56. Jacob, R., E. Barrett, G. Plewe, K. D. Fagin, and R. S. Sherwin. 1989. Acute effects of insulin-like growth factor I on glucose and amino acid metabolism in the awake fasted rat. J. Clin. Invest. 83:1717-1723.
57. Sinha, M. K., C. Buchanan, N. Leggett, L. Martin, P. G. Khazanie, R. DiMarchi, W. J. Pones, and J. F. Caro. 1989. Mechanism of IGF-I-stimulated glucose transport in human adipocytes: demonstration of specific IGF-I receptors not involved in stimulation of glucose transport. Diabetes. 38:1217-1225.
58. Caro, J. F., J, Poulos, O. Ittoop, W. J. Pories, E. G. Flickinger, and M. K. Sinha. 1988. Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal liver. J. Clin. Invest. 81:976-981.
59. Clemmons, D. R., and L. E. Underwood. 1991. Nutritional regulation of IGF-I and IGF binding proteins. Annu. Rev. Nutr. 11:393-412.
60. Hartman, M. L., and M. O. Thorner. 1990. Fasting-induced enhancement of pulsatile growth hormone (GH) secretion is rapidly abolished by refeeding. Prog. 72nd Meeting of the Endocrine Soc. 55. (Abstr. 123).