Acute ethanol intoxication increases the risk of infection following penetrating abdominal trauma

Journal of Trauma - Injury, Infection and Critical Care

Volumn 34, Issue 5, 1993, Pages 669-675

  Gentilello, Larry M ^a   Cobean, Roy A ^a   Walker, Alonzo P ^b   Moore, Ernest E ^c,d   Wertz, Margaret J ^a   Dellinger, E Patchen ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^b MEDICAL COLLEGE OF WISCONSIN   (United States)

^c UNIVERSITY OF COLORADO   (United States)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL; CEFOXITIN; PIPERACILLIN;

ABDOMINAL PENETRATING TRAUMA; ADULT; ALCOHOL BLOOD LEVEL; ALCOHOL INTOXICATION; ALCOHOLISM; ARTICLE; HOSPITAL INFECTION; HUMAN; INFECTION RISK; MAJOR CLINICAL STUDY; PRIORITY JOURNAL;

ABDOMINAL INJURIES; ALCOHOL DRINKING; BACTERIAL INFECTIONS; BLOOD TRANSFUSION; COLON; CROSS INFECTION; HUMAN; RISK FACTORS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; WOUNDS, PENETRATING;

EID: 0027246603     PISSN: 00225282     EISSN: 15298809     Source Type: Journal    
DOI: 10.1097/00005373-199305000-00009     Document Type: Article

References (34)

1. MacGregor RR: Alcohol and immune defense. JAMA 256:1474, 1986.
2. Grossman CJ, Mendenhall CL, Roselle GA: Alcohol and immune regulation: In vivo effects of ethanol on concanavalin A sensitive thymic lymphocyte function. Int J Immunopharmacol 10:187, 1988.
3. Malt SH, Baue AE: The effects of ethanol as related to trauma in the awake dog. J Trauma 11:76, 1971.
4. Levallois C, Rouahi N, Balmes JL, et al: The effects of ethanol in vitro on some parameters of the immune response. Drug Alcohol Depend 24:239,1989.
5. Oreskovich MR, Dellinger EP, Lennard ES, et al: Duration of preventive antibiotic administration for penetrating abdominal trauma. Arch Surg 117:200,1982.
6. Dellinger EP, Oreskovich MR, Wertz MJ, et al: Risk of infection following laparotomy for penetrating abdominal injury. Arch Surg 119:20,1984.
7. Dellinger EP, Wertz MJ, Lennard ES, et al: Efficacy of short- course antibiotic prophylaxis after penetrating intestinal injury. Arch Surg 121:23, 1986.
8. Moore EE, Dunn EL, Moore JB, et al: Penetrating Abdominal Trauma Index. J Trauma 21:439, 1981.
9. Champion HR, Sacco WJ, Carnazzo AJ, et al: The Trauma Score. Crit Care Med 9:672, 1981.
10. Knaus WA, Draper EA, Wagner DP, et al: APACHE II: A severity of disease classification. Crit Care Med 13:818, 1985.
11. Fullen WD, Hunt J, Altemeier WA: Prophylactic antibiotics in penetrating wounds of the abdomen. J Trauma 12:282, 1972.
12. Haygood FD, Polk HC Jr: Gunshot wounds of the colon: A review of 100 consecutive patients, with emphasis on complications and their causes. Am J Surg 131:213,1976.
13. Josen AS, Ferrer JM Jr, Forde KA, et al: Primary closure of civilian colorectal wounds. Ann Surg 176:782, 1972.
14. Stone HH, Fabian TC: Management of perforating colon trauma: Randomization between primary closure and exteriorization. Ann Surg 190:430, 1979.
15. Flint LM, Vitale GC, Richardson JD, et al: The injured colon: Relationships of management to complications. Ann Surg 193:619, 1981.
16. Esrig BC, Frazee L, Stephenson SF, et al: The predisposition to infection following hemorrhagic shock. Surg Gynecol Obstet 128:713, 1969.
17. Dellinger, EP: Antibiotic prophylaxis in trauma: Penetrating abdominal injuries and open fractures. Rev Infect Dis 13 (suppl):S847, 1991.
18. Nichols RL, Smith JW, Klein DB, et al: Risk of infection after penetrating abdominal trauma. N Engl J Med 311:1065, 1984.
19. Liu YK: Effects of alcohol on granulocytes and lymphocytes. Semin Hematol 17:130, 1980.
20. Jerrels TR, Marietta CA, Eckardt MJ, et al: Effects of ethanol administration on parameters of immunocompetency in rats. J Leukoc Biol 39:499,1986.
21. Kawakami M, Switzer BR, Herzog SR, et al: Immune suppression after acute ethanol ingestion and thermal injury. J Surg Res 51:210,1991.
22. MacGregor RR, Gluckman SG: Effect of acute alcohol intoxication on granulocyte mobilization and kinetics. Blood 52:551, 1979.
23. Pickrell KL: The effect of alcoholic intoxication and ether anesthesia on resistance to pneumococcal infection. Bull Johns Hopkins Hosp 63:238, 1938.
24. Gluckman SJ, Dvorak VC, MacGregor RR: Host defenses during prolonged alcohol consumption in a controlled environment. Arch Intern Med 137:1539, 1977.
25. Brayton RG, Stokes PE, Schwartz MS, et al: Effect of alcohol and various diseases on leukocyte mobilization, phagocytosis and intracellular bacterial killing. N Engl J Med 282:123, 1970.
26. Louria DB: Susceptibility to infection during experimental alcoholic intoxication. Trans Assoc Am Physicians 76:102, 1963.
27. Green GM, Kass EH: Factors influencing the clearance of bacteria by the lung. J Clin Invest 43:769, 1964.
28. Lowenstein SR, Weissberg MP, Terry BA: Alcohol intoxication, injuries, and dangerous behaviors—and the revolving emergency department door. J Trauma 30:1252, 1990.
29. Waller JA: Management issues for trauma patients with alcohol. J Trauma 30:1448, 1990.
30. Simel D, Feusner J: Blood alcohol measurements in the emergency department: Who needs them? Am J Public Health 78:1478,1988.
31. Chan G, Astrachan B: The emergency department surveillance of alcohol intoxication after motor vehicle accidents. JAMA 260:2533, 1988.
32. Gentilello LM, Duggan P, Drummond D, et al: Major injury as a unique opportunity to initiate treatment in the alcoholic. Am J Surg 156:558,1988.
33. Söderström CA, Cowley R: A national alcohol and trauma center survey: Missed opportunities, failures of responsibility. Arch Surg 122:1067, 1987.
34. US Public Health Service, Office of the Surgeon General. Surgeon General’s Workshop on Drunk Driving. Rockville, Md, U.S. Department of Health and Human Services, 1989