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Volumn 104, Issue 6, 1993, Pages 1832-1847

Side effects of nonsteroidal anti-inflammatory drugs on the small and large intestine in humans

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLSALICYLIC ACID; DICLOFENAC; FENBUFEN; FLUFENAMIC ACID; IBUPROFEN; INDOMETACIN; MEFENAMIC ACID; METRONIDAZOLE; MISOPROSTOL; NAPROXEN; NONSTEROID ANTIINFLAMMATORY AGENT; PIROXICAM; SALAZOSULFAPYRIDINE;

EID: 0027244454     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/0016-5085(93)90667-2     Document Type: Review
Times cited : (983)

References (229)
  • 1
    • 0023986564 scopus 로고
    • Nonsteroidal antiinflammatory drugs-another look
    • (1989) Br J Rheumatol , vol.27 , pp. 87-90
    • Gibson1
  • 2
    • 0024338076 scopus 로고
    • Current controversies in rheumatology. Controversies in detection and management of non-steroidal anti-inflammatory drug induced side effects on upper gastrointestinal tract
    • (1989) Arthritis Rheum , vol.32 , pp. 926-929
    • Barrier1    Hirschowitz2
  • 4
    • 0016400623 scopus 로고
    • Aspirin use in patients with major gastrointestinal bleeding and peptic ulceration
    • (1974) N Engl J Med , vol.290 , pp. 1158-1162
    • Levi1
  • 5
    • 0016957157 scopus 로고
    • Aspirin in chronic gastric ulcer: an Australian experience
    • (1976) Gut , vol.17 , pp. 378-384
    • Duggen1
  • 6
    • 0016638732 scopus 로고
    • An endoscopic evaluation of the effects of non-steroidal anti-inflammatory agents on the gastric mucosa
    • (1975) Gastrointest Endosc , vol.21 , pp. 103-105
    • Lanza1    Royer2    Nelson3
  • 7
    • 0023513663 scopus 로고
    • Non-steroidal anti-inflammatory drug gastropathy recognition and response
    • (1987) Arch Int Med , vol.147 , pp. 2093-2100
    • Roth1    Bennett2
  • 9
    • 0018826501 scopus 로고
    • Comparison of the effects of regular and enteric-coated aspirin on gastroduodenal mucosa in man
    • (1980) Lancet , vol.1 , pp. 609-612
    • Hoftiezer1    Silvoso2    Burks3    Ivey4
  • 10
    • 0022641477 scopus 로고
    • Contrasting presentation and findings between patients with rheumatic complaints taking non-steroidal anti-inflammatory drugs and a general population referred to endoscopy
    • (1986) Br J Rheumatol , vol.25 , pp. 50-53
    • Collins1    Davies2    Dixon3
  • 11
    • 0024497798 scopus 로고
    • Epidemiological evidence on the association between peptic ulceration and antiinflammatory drugs
    • (1989) Gastroenterology , vol.96 , pp. 640-646
    • Langman1
  • 13
    • 0023697639 scopus 로고
    • Prevention of non-steroidal antiinflammatory drug induced gastric ulceration with Misoprostol; multicenter, double blind placebo controlled trial
    • (1988) Lancet , vol.2 , pp. 1277-1280
    • Graham1    Agrawal2    Roth3
  • 15
    • 0019496140 scopus 로고
    • Effects of aspirin on the human stomach in normals. Endoscopic comparison of damage produced at 1 hour, 24 hours and 2 weeks after administration
    • (1981) Scand J Gastroenterol , vol.16 , pp. 211-214
    • O'Laughlin1    Hofteizer2    Ivey3
  • 16
    • 0025666838 scopus 로고
    • Endoscopic evaluation of cimethidine and sucralfate for prevention of naproxen-induced gastroduodenal injury: effects of scoring method
    • (1990) Dig Dis Sci , vol.35 , pp. 1494-1499
    • Lanza1    Graham2    Davis3    Rack4
  • 17
    • 0019362571 scopus 로고
    • Gastroscopic findings after therapy with nonsteroidal anti-inflammatory drugs
    • (1981) J Rheumatol , vol.40 , pp. 179-181
    • Tympner1
  • 18
    • 84908829556 scopus 로고
    • Endoscopic and microscopic findings in symptomatic and asymptomatic patients on long term nonsteroidal anti-inflammatory drug treatment (abstr)
    • (1990) Gastroenterology , vol.98 , pp. A109
    • Quinn1    Price2    Bjarnason3
  • 19
    • 0023874092 scopus 로고
    • Chronic gastritis—a pathogenic approach
    • (1988) J Pathol , vol.154 , pp. 113-124
    • Wyatt1    Dixon2
  • 21
    • 0026529205 scopus 로고
    • Chemical gastritis and Helicobacter pylori related gastritis in patients receiving nonsteroidal anti-inflammatory drugs: Comparison and correlation with peptic ulceration
    • (1992) J Clin Pathol , vol.45 , pp. 135-139
    • Taha1    Nakshabendi2    Iee3    Sturrock4    Russell5
  • 25
    • 0024618389 scopus 로고
    • Non-steroidal anti-inflammatory drug-induced ulcers: management by traditional therapies
    • (1989) Gastroenterology , vol.96 , pp. 662-674
    • McCarthy1
  • 30
    • 0024356825 scopus 로고
    • Gastrointestinal events in patients prescribed NSAIDs: a controlled study using record linkage in Tayside
    • (1989) Quat J Med , vol.71 , pp. 497-505
    • Beardon1    Brown2    Mcdevitt3
  • 31
    • 0023217399 scopus 로고
    • Nonsteroidal anti-inflammatory drugs and life threatening complications of peptic ulcer disease
    • (1987) Gut , vol.28 , pp. 527-532
    • Armstrong1    Blower2
  • 35
    • 0021063898 scopus 로고
    • Enteritis and colitis associated with mefenamic acid
    • (1983) BMJ , vol.287 , pp. 1627
    • Edwards1    Heagerty2    Bing3
  • 36
    • 0021063898 scopus 로고
    • Enteritis and colitis associated with mefenamic acid
    • (1983) BMJ , vol.287 , pp. 1627
    • Rampton1    Trapping2
  • 38
    • 0021063898 scopus 로고
    • Enteritis and colitis associated with mefenamic acid
    • (1983) BMJ , vol.287 , pp. 1627
    • Williams1    Glazier2
  • 42
    • 0021050496 scopus 로고
    • Proctocolitis induced by salicylate and associated with asthma and recurrent nasal polyps (letter)
    • (1983) Br Med J , vol.287 , pp. 1675
    • Pearson1    Stones2    Bentley3    Reid4
  • 44
  • 45
    • 0026752358 scopus 로고
    • Diclofenac-induced pseudomembraneous colitis
    • (1992) Lancet , vol.340 , pp. 126-127
    • Gentric1    Pennec2
  • 47
    • 0024435795 scopus 로고
    • Non-steroidal anti-inflammatory drugs and the bowel
    • (1989) Lancet , vol.2 , pp. 1047-1048
    • Bunney1
  • 53
    • 0014030519 scopus 로고
    • Ulcer of the caecum during oxyphenylbutazone (Tanderil) therapy
    • (1966) Can Med Assoc J , vol.94 , pp. 1182-1184
    • Debenham1
  • 60
    • 0021959535 scopus 로고
    • Use of anti-inflammatory drugs by patients with small or large bowel perforation and haemorrhage
    • (1985) Br Med J , vol.290 , pp. 347-349
    • Langman1    Morgan2    Worrall3
  • 61
    • 0009361547 scopus 로고
    • Indomethacin suppositories
    • (1965) Br Med J , vol.1 , pp. 1497
    • Woolf1
  • 65
    • 0016845909 scopus 로고
    • Rectal bleeding and indomethacin suppositories
    • (1975) Lancet , vol.305 , pp. 577
    • Levy1    Gaspar2
  • 70
    • 0021026118 scopus 로고
    • Intestinal perforation associated with slow release indomethacin capsules
    • (1983) Br Med J , vol.287 , pp. 1671-1672
    • Day1
  • 71
    • 0019841030 scopus 로고
    • Lower gastrointestinal side effects of nonsteroidal antiinflammatory drugs
    • (1981) J Rheumatol , vol.8 , pp. 952-954
    • Schwartz1
  • 73
    • 0023472344 scopus 로고
    • Steroids, non-steroidal anti-inflammatory drugs and serious complications of diverticular disease
    • (1987) Br J Med , vol.295 , pp. 1238
    • Corder1
  • 75
    • 0025169347 scopus 로고
    • Complications of diverticular disease and nonsteroidal anti-inflammatory drugs: A prospective study
    • (1990) Br J Surg , vol.77 , pp. 1103-1104
    • Wilson1    Smith2    Macintyre3
  • 76
    • 0025981402 scopus 로고
    • Non-steroidal anti-inflammatory drugs and complicated diverticular disease: a case-control study
    • (1991) Br J Surg , vol.78 , pp. 190-191
    • Campbell1    Steele2
  • 78
    • 0022340674 scopus 로고
    • Prostaglandins and the gastrointestinal mucosa: are they important in its function, disease or treatment?
    • (1985) Gastroenterology , vol.89 , pp. 1162-1188
    • Hawkey1    Rampton2
  • 80
    • 0019444287 scopus 로고
    • Prostaglandin synthesis inhibition in ulcerative colitis. Flurbiprofen compared with conventional treatment
    • (1981) Prostaglandins , vol.21 , pp. 417-425
    • Rampton1    Sladen2
  • 83
    • 0020680648 scopus 로고
    • Analgesic ingestion and other factors preceding relapse in ulcerative colitis
    • (1983) Gut , vol.24 , pp. 187-189
    • Rampton1    McNeil2    Sarner3
  • 87
    • 0021995275 scopus 로고
    • Intestinal perforation following enteral administration of indomethacin
    • (1985) J Pediatr , vol.107 , pp. 484-485
    • Marshall1
  • 93
    • 0019938421 scopus 로고
    • Upper gastrointestinal lesions after potassium chloride supplements: A controlled trial
    • (1982) Lancet , vol.2 , pp. 1059-1060
    • McMahon1    Ryan2    Akdamar3    Ertan4
  • 95
    • 0013934123 scopus 로고
    • Drug induced ulceration and perforation of the small bowel
    • (1966) Ariz Med , vol.23 , pp. 517-523
    • Shack1
  • 96
    • 0015576440 scopus 로고
    • Ulcers and strictures of the jejunum in a patient on long term indomethacin therapy
    • (1973) Am J Gastroenterol , vol.59 , pp. 162-169
    • Sturges1    Krone2
  • 98
    • 0020683922 scopus 로고
    • Recurrent small bowel obstruction associated with phenylbutazone
    • (1983) Br J Surg , vol.70 , pp. 244-245
    • Neoptolemos1    Locke2
  • 101
    • 0023136835 scopus 로고
    • Recurrent small bowel obstruction with piroxicam
    • (1987) Br J Surg , vol.74 , pp. 186
    • Sukumar1
  • 105
    • 0345022097 scopus 로고
    • Endoscopic description of diaphragm disease induced by non-steroidal anti-inflammatory drugs
    • (1992) Gastroint Endosc , vol.38 , pp. 267
    • Hershfield1
  • 113
    • 0014116731 scopus 로고
    • Anatomy and embryology of congenital intrinsic obstruction of the duodenum
    • (1967) Am J Surg , vol.114 , pp. 190-202
    • Boyden1    Cope2    Bill3
  • 114
    • 0006945772 scopus 로고
    • Congenital intestinal atresia and stenosis in the newborn. Observation on its pathogenesis and treatment
    • (1959) Ann Roy Coll Surg , vol.25 , pp. 209-234
    • Louw1
  • 115
  • 116
    • 0023912898 scopus 로고
    • Sulphasalazine II. Some notes on the discovery and development of salazopyrin
    • (1988) Am J Gastroenterol , vol.83 , pp. 497-503
    • Svartz1
  • 117
    • 84914403868 scopus 로고
    • Editorial. Rheumatoid arthritis and the gut
    • (1979) Br Med J , vol.278 , pp. 1104
  • 120
    • 0015396743 scopus 로고
    • The primary cause of rheumatoid arthritis is an infection. The infectious agent exists in milk
    • (1972) Acta Med Scand , vol.192 , pp. 231-239
    • Svartz1
  • 121
    • 0023677493 scopus 로고
    • Historical aspects of the aetiology of rheumatoid arthritis
    • (1988) Br J Rheumatol , vol.27 , pp. 110-115
    • Bywaters1
  • 124
    • 0002408142 scopus 로고
    • The treatment of poly-arthritis with acid azo compounds
    • (1948) Rheumatism , vol.4 , pp. 56-60
    • Svartz1
  • 125
    • 0021989128 scopus 로고
    • Which component of sulphasalazine is active in rheumatoid arthritis?
    • (1985) Br Med J , vol.290 , pp. 1535-1538
    • Pullar1    Hunter2    Capell3
  • 127
    • 0025728830 scopus 로고
    • Sulphasalazine in inflammatory bowel disease-In memoriam?
    • (1991) Gut , vol.32 , pp. 462-463
    • Hayllar1    Bjarnason2
  • 129
    • 0021080390 scopus 로고
    • The cross tolerance hypothesis, HLA-B-27 and ankylosing spondylitis
    • (1983) Br J Rheumatol , vol.22 , pp. 53-66
    • Ebringer1
  • 130
    • 0023764413 scopus 로고
    • Molecular mimicry: Fact or fiction?
    • (1988) Br J Rheumatol , vol.27 , pp. 95-105
    • Yu1
  • 131
    • 0023182772 scopus 로고
    • Autoantibodies to HLA-B27 in sera of HLA-B27 patients with ankylosing spondylitis and Reiters syndrome: molecular mimicry with Klebsiella pneumonia as potential mechanism of autoimmune disease
    • (1987) J Exp Med , vol.166 , pp. 173-181
    • Schwimmbeck1    Yu2    Oldstone3
  • 136
    • 0022540252 scopus 로고
    • Lactulose, 51-Cr labelled ethylenediaminetetraacetate, l-rhamnose and polyethylene glycol 400 as probe markers for assessment of in vivo of human intestinal permeability
    • (1986) Clin Sci , vol.71 , pp. 71-80
    • Maxton1    Bjarnason2    Reynolds3    Catt4    Peters5    Menzies6
  • 141
    • 0025193854 scopus 로고
    • 51 Cr-ethylenediaminetetraacetic acid absorption test. Effects of naproxen, a non-steroidal anti-inflammatory drug
    • (1990) Scand J Gastroenterol , vol.25 , pp. 917-927
    • Aabakken1    Osnes2
  • 143
    • 0026019375 scopus 로고
    • The importance of local versus systemic effects of non-steroidal anti-inflammatory drugs to increase intestinal permeability in man
    • (1991) Gut , vol.32 , pp. 275-277
    • Bjarnason1    Fehilly2    Smethurst3    Menzies4    Levi5
  • 144
    • 0026320406 scopus 로고
    • The pro-drug sulindac may reduce the risk of intestinal damage associated with the use of conventional non-steroidal antiinflammatory drugs
    • (1991) Aliment Pharmacol Ther , vol.5 , pp. 593-598
    • Davies1    Rampton2
  • 146
    • 0024846128 scopus 로고
    • Cimetidine tablets or suspension in the prevention of gastrointestinal mucosal lesions caused by nonsteroidal anti-inflammatory drugs
    • (1989) Scand J Rheumatol , vol.18 , pp. 647-655
    • Aabakken1    Larsen2    Osnes3
  • 148
    • 85038138144 scopus 로고    scopus 로고
    • Jenkins RT, Rooney PJ, Hunt RH. Increased bowel permeability of 51 CrEDTA in controls caused by naproxen is not prevented by Cytotec.
  • 151
    • 0005476254 scopus 로고
    • Relevance of intestinal bacteria, prostaglandins and pro-drug administration to NSAID induced increase in gut permeability (abstr)
    • (1991) Gut , vol.32 , pp. A1224
    • Davies1    Rampton2
  • 162
    • 0007830083 scopus 로고
    • Clinical investigation of patients with malabsorption and diarrhoea
    • Fourth ed, I.A.D Bouchier, RN Allan, H.J.F Hodgson, M.R.B Keighley, Bailliere Tindall, London
    • (1984) Textbook of Gastroenterology , pp. 428-441
    • Chadwick1
  • 164
    • 0022558917 scopus 로고
    • 111-Indium-labelled polymorphonuclear leucocyte scans in rheumatoid arthritis—an important clinical cause of positive results
    • (1986) Br J Rheumatol , vol.25 , pp. 167-170
    • Rooney1    Jenkins2    Smith3    Coates4
  • 165
    • 0026772822 scopus 로고
    • Small bowel enteroscopy in undiagnosed gastrointestinal blood loss
    • (1992) Gut , vol.33 , pp. 887-889
    • Morris1    Wasson2    MacKenzie3
  • 166
    • 85044496998 scopus 로고
    • Small bowel enteroscopy (letter)
    • (1991) Lancet , vol.337 , pp. 1093
    • Lewis1
  • 167
    • 0023179884 scopus 로고
    • Upper gastrointestinal findings and faecal occult blood in patients with rheumatic disease taking non-steroidal anti-inflammatory drugs
    • (1987) Br J Rheumatol , vol.26 , pp. 295-298
    • Collins1    A du Toit2
  • 168
    • 0022905353 scopus 로고
    • Nonsteroidal anti-inflammatory drugs and gastrointestinal bleeding: A case-control study
    • (1986) Arch Int Med , vol.146 , pp. 2365-2367
    • Bartle1    Gupta2    Lazor3
  • 169
    • 0021689999 scopus 로고
    • Significance of a positive test for occult blood in stools of patients taking anti-inflammatory drugs
    • (1984) Arch Int Med , vol.144 , pp. 2165-2166
    • Bahrt1    Korman2    Nashel3
  • 171
    • 4243412815 scopus 로고
    • Intestinal inflammation and bleeding in NSAID enteropathy and inflammatory bowel disease (abstr)
    • (1990) Gut , vol.31 , pp. A593
    • Teahon1    Levi2    Bjarnason3
  • 175
    • 0023915988 scopus 로고
    • Decreased iron absorption in patients with active rheumatoid arthritis, with and without iron deficiency
    • (1988) Ann Rheum Dis , vol.47 , pp. 404-409
    • Weber1    Werre2    Julius3    Marx4
  • 176
  • 185
    • 0025044238 scopus 로고
    • Experience with the use of a gastrointestinal marker (51 CrCl3) in a combined study of ileal function using 75SeHCAT and 58CoVitB12 measured by whole body counting
    • (1990) Gut , vol.31 , pp. 1120-1125
    • Smith1    Bjarnason2
  • 186
  • 190
    • 85038146402 scopus 로고    scopus 로고
    • Somasundaram S, Hayllar J, Macpherson A, Bjarnason I. The biochemical basis of NSAID-induced gastrointestinal damage: A review and a hypothesis (submitted).
  • 193
    • 0015899017 scopus 로고
    • Effects of salicylate and related compounds in gastric HCl secretions
    • (1973) Am J Physiol , vol.225 , pp. 521-527
    • Kaedekar1
  • 194
    • 0017692109 scopus 로고
    • Effects of acetylsalicylic acid on gastric mucosa. II. Mucosal ATP and phosphocreatine content and salicylic effects on mitochondrial metabolism
    • (1977) Gastroenterology , vol.73 , pp. 995-999
    • Spenny1    Bhown2
  • 197
    • 0022451875 scopus 로고
    • Effects of cytochalasin D on occluding junctions of intestinal absorptive cells: further evidence that the cytoskeleton may influence paracellular permeability and junctional charge selectivity
    • (1986) J Cell Biol , vol.102 , pp. 2125-2136
    • Madara1    Barenberg2    Carlson3
  • 198
  • 199
    • 0023631266 scopus 로고
    • Alterations in intestinal tight junction structure and permeability by cytoskeletal contraction
    • (1987) Am J Physiol , vol.253 , pp. C854-C861
    • Madara1    Moore2    Carlson3
  • 200
    • 0019351569 scopus 로고
    • Temporal relationship between cyclooxygenase inhibition, as measured by prostacyclin biosynthesis, and gastrointestinal damage induced by indomethacin in the rat
    • (1981) Gastroenterology , vol.80 , pp. 94-98
    • Whittle1
  • 201
    • 0023727278 scopus 로고
    • Effects of nonsteroidal anti-inflammatory drugs on gastrointestinal injury and prostanoid generation in healthy volunteers
    • (1988) Dig Dis Sci , vol.33 , pp. 660-666
    • Levine1    Petokas2    Nandi3    Enthoven4
  • 203
    • 0024552168 scopus 로고
    • Role of prostaglandins in preventing gastrointestinal ulceration: Induction of ulcers by antibodies to prostaglandins
    • (1989) Gastroenterology , vol.96 , pp. 596-605
    • Redfern1    Feldman2
  • 206
    • 0017690751 scopus 로고
    • Resistance of germ free rats to indomethacin-induced intestinal lesions
    • (1977) Prostaglandins , vol.14 , pp. 331-341
    • Robert1    Asano2
  • 207
    • 0020678175 scopus 로고
    • Role of bacteria in gastric ulceration produced by indomethacin in the rat: cytoprotective action of antibiotics
    • (1983) Gastroenterology , vol.84 , pp. 483-489
    • Satoh1    Guth2    Grossman3
  • 208
    • 0023708676 scopus 로고
    • Mucosal lesions induced in the rat intestinal tract by the anti-inflammatory drug Wy-41770 a weak inhibitor of prostaglandin synthesis contrasted with those from the potent prostaglandin inhibitor indomethacin
    • (1988) Toxicologic Pathology , vol.16 , pp. 366-375
    • Rainsford1
  • 218
    • 0025078185 scopus 로고
    • Gastric ulceration induced by nonsteroidal antiinflammatory drugs is a neutrophil dependent process
    • (1990) Am J Physiol , vol.259 , pp. G462-G467
    • Wallace1    Keenan2    Granger3
  • 219
    • 0025727507 scopus 로고
    • A monoclonal antibody against the CD 18 leucocyte adhesion molecule prevents indomethacin-induced gastric damage in the rabbit
    • (1991) Gastroenterology , vol.100 , pp. 878-883
    • Wallace1    Arfors2    McKnight3
  • 223
    • 0024602827 scopus 로고
    • Tissue destruction by neutrophils
    • (1989) N Engl J Med , vol.320 , pp. 365-376
    • Weiss1


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