p53 gene mutations and 17p allelic deletions in hepatocellular Carcinoma from Japan

Cancer

Volumn 72, Issue 2, 1993, Pages 355-360

  Nose, Haruhiko ^a   Imazeki, Fumio ^a   Ohto, Masao ^a   Omata, Masao ^b  

^a CHIBA UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b UNIVERSITY OF TOKYO   (Japan)

Author keywords

hepatocellular carcinoma; p53 gene; polymerase chain reaction; restriction fragment length polymorphism

Indexed keywords

AFLATOXIN; PROTEIN P53;

ADULT; AGED; ALLELE; ARTICLE; CHINA; CHROMOSOME 17P; CHROMOSOME DELETION; CLINICAL ARTICLE; CODON; EXON; FEMALE; FOOD CONTAMINATION; GENE MUTATION; GENE SEQUENCE; HEPATITIS B; HEPATITIS C; HUMAN; HUMAN TISSUE; JAPAN; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; RISK FACTOR; SOUTH AFRICA;

ALLELES; BASE SEQUENCE; CARCINOMA, HEPATOCELLULAR; CHROMOSOME DELETION; CHROMOSOMES, HUMAN, PAIR 17; FEMALE; GENES, P53; HUMAN; JAPAN; LIVER NEOPLASMS; MALE; MOLECULAR SEQUENCE DATA; MUTATION; POLYMERASE CHAIN REACTION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH;

EID: 0027243142     PISSN: 0008543X     EISSN: 10970142     Source Type: Journal    
DOI: 10.1002/1097-0142(19930715)72:2<355::AID-CNCR2820720208>3.0.CO;2-W     Document Type: Article

References (45)

1. Hepatitis C and hepatitis B in the etiology of hepatocellular carcinoma in the Japanese population
2. Relation of the hepatitis B virus carrier state to hepatocellular carcinoma
3. HBx gene of hepatitis B virus induces liver cancer in transgenic mice
4. Hepatitis B virus DNA integration in a sequence homologous to v‐erb‐A and steroid receptor genes in a hepatocellular carcinoma
5. Hepatitis B virus integration in a cyclin A gene in a hepatocellular carcinoma
6. Molecular pathogenesis of hepatocellular carcinoma in hepatitis B virus transgenic mice
7. Genetic alterations during colorectal tumor development
8. Ras oncogene in human cancer: a review
9. Mutations in the p53 gene occur in diverse human tumor types
10. p53 mutations in human cancers
11. Analysis of ras gene mutations in human hepatic tumors by polymerase chain reaction and direct sequencing
12. Loss of heterozygosity suggests tumor suppressor gene responsible for primary hepatocellular carcinoma
13. Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma
14. Allelotype study of primary hepatocellular carcinoma
15. Abnormal structure and expression of the p53 gene in human hepatocellular carcinoma
16. Hepatitis B virus integration event in human chromosome 17p near the p53 gene identifies the region of the chromosome commonly deleted in virus‐positive hepatocellular carcinomas
17. Mutational hotspot in the p53 gene in human hepatocellular carcinomas
18. Selective G to T mutations of p53 gene in hepatocellular carcinoma from South Africa
19. RNA transcripts of hepatitis B virus in hepatocellular carcinoma
20. Detection of specific sequences among DNA fragments separated by gel electrophoresis
21. Isolation and mapping of a polymorphic DNA sequence (pYNZ22) on chromosome 17p [D17S30]
22. Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I
23. Genomic sequencing
24. Primer‐directed enzymatic amplification of DNA with a thermostable DNA polymerase
25. Characterization of the human p53 gene
26. A variation in the structure of the protein‐coding region of the human p53 gene
27. Nucleotide sequence of a cDNA encoding the chicken p53 nuclear oncoprotein
28. p53 mutations in human cancers
29. T antigen is bound to a host protein in SV40‐transformed cells
30. Participation of p53 cellular tumor antigen in transformation of normal embryonic cells
31. Cooperation between gene coding p53 tumor antigen and ras in cellular transformation
32. Mutation is required to activate the p53 gene for cooperation with the ras oncogene and transformation
33. The p53 gene proto‐oncogene can act as a suppressor of transformation
34. The p53 tumor suppressor gene
35. Alterations in the p53 gene and the clonal evolution of the blast crisis of chronic myelocytic leukemia
36. p53: a frequent target for genetic abnormalities in lung cancer
37. Frequency and structure of p53 rearrangements in human osteosarcoma
38. Major deletions in the gene encoding the p53 tumor antigen cause lack of p53 expression in HL‐60 cells
39. Rearrangement of the p53 gene in human osteogenic sarcomas
40. Molecular analysis of the p53 alleles in primary hepatocellular carcinomas and cell lines
41. Aberrations of the tumor suppressor p53 and retinoblastoma genes in human hepatocellular carcinomas
42. p53 mutation in hepatocellular carcinoma after aflatoxin exposure
43. Aflatoxin exposure in human populations: measurements and relationship to cancer