Quinolone Antibacterials: Synthesis and Biological Activity of Carbon Isosteres of the 1-Piperazinyl and 3-Amino-1-pyrrolidinyl Side Chains

Journal of Medicinal Chemistry

Volumn 36, Issue 14, 1993, Pages 1964-1970

  Laborde, Edgardo ^a   Kiely, John S ^a   Culbertson, Townley P ^a   Lesheski, Lawrence E ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

6 FLUORO 1,4 DIHYDRO 4 OXO 1,8 NAPHTHYRIDINE 3 CARBOXYLIC ACID DERIVATIVE; 6 FLUORO 1,4 DIHYDRO 4 OXO 3 QUINOLINECARBOXYLIC ACID DERIVATIVE; DNA TOPOISOMERASE (ATP HYDROLYSING); QUINOLINE DERIVED ANTIINFECTIVE AGENT; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; ANTI-INFECTIVE AGENTS, QUINOLONE; DNA TOPOISOMERASES, TYPE II; FEMALE; MICE; MICROBIAL SENSITIVITY TESTS; PIPERAZINES; PYRROLIDINES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0027240178     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00066a005     Document Type: Article

References (26)

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