What determines the strength of noncovalent association of ligands to proteins in aqueous solution?

Proceedings of the National Academy of Sciences of the United States of America

Volumn 90, Issue 18, 1993, Pages 8402-8406

  Miyamoto, Shuichi ^a,b   Kollman, Peter A ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b KITASATO UNIVERSITY   (Japan)

Author keywords

Avidin; Free energy calculation; Molecular dynamics; chymotrypsin

Indexed keywords

BIOTIN; CHYMOTRYPSIN; LIGAND; N ACETYLTRYPTOPHAN; STREPTAVIDIN;

AQUEOUS SOLUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; DISPERSION; ENERGY; LIGAND BINDING; MATHEMATICAL MODEL; MOLECULAR RECOGNITION; PRIORITY JOURNAL; PROTEIN BINDING; THERMODYNAMICS;

BACTERIAL PROTEINS; BIOTIN; CALORIMETRY; CHYMOTRYPSIN; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEINS; STREPTAVIDIN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; TRYPTOPHAN;

EID: 0027239578     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.90.18.8402     Document Type: Article

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