메뉴 건너뛰기




Volumn 62, Issue 3, 1993, Pages 289-296

n Vitro Effects of the New Calcium Antagonist Lacidipine

Author keywords

Cardiac muscle; diethyl 4 2 3 ( ) l,1 dimethylethoxy) 3 ; Lacidipine; Nifedipine; Organ selectivity; Vascular smooth muscle

Indexed keywords

CALCIUM ANTAGONIST; LACIDIPINE; NIFEDIPINE; POTASSIUM ION;

EID: 0027234761     PISSN: 00215198     EISSN: None     Source Type: Journal    
DOI: 10.1254/jjp.62.289     Document Type: Article
Times cited : (6)

References (26)
  • 1
    • 0010988762 scopus 로고
    • GX 1048 (GR 43659X), a new dihydropyridine calcium antagonist with potent and long-lasting antihypertensive action.
    • Carpi, C., Gaviraghi, G. and Semeraro, C.; GX 1048 (GR 43659X), a new dihydropyridine calcium antagonist with potent and long-lasting antihypertensive action. Br. J. Pharmacol. 89, Supp. 758 P (1986)
    • (1986) Br. J. Pharmacol. , vol.89 , pp. 758
    • Carpi, C.1    Gaviraghi, G.2    Semeraro, C.3
  • 2
    • 0025255628 scopus 로고
    • Lacidipine: A calcium antagonist with potent and long-lasting antihypertensive effects in animal studies.
    • Micheli, D., Collodel, A., Semeraro, C., Gaviraghi, G. and Carpi, C.: Lacidipine: A calcium antagonist with potent and long-lasting antihypertensive effects in animal studies. J. Cardiovasc. Pharmacol. 15, 666-675 (1990)
    • (1990) J. Cardiovasc. Pharmacol. , vol.15 , pp. 666-675
    • Micheli, D.1    Collodel, A.2    Semeraro, C.3    Gaviraghi, G.4    Carpi, C.5
  • 3
    • 0014847523 scopus 로고
    • Calcium-dependent action potentials produced by catecholamine in guinea pig atrial muscle fibers depolarized by potassium.
    • Pappano, A.J.: Calcium-dependent action potentials produced by catecholamine in guinea pig atrial muscle fibers depolarized by potassium. Circ. Res. 27, 379-390 (1970)
    • (1970) Circ. Res. , vol.27 , pp. 379-390
    • Pappano, A.J.1
  • 4
    • 0018897559 scopus 로고
    • Evidence for greater sus-ceptibihty of isolated dog cerebral arteries to Ca antagonists than peripheral arteries.
    • Shimizu, K., Ohta, T. and Toda, N.: Evidence for greater sus-ceptibihty of isolated dog cerebral arteries to Ca antagonists than peripheral arteries. Stroke 11, 261-266 (1980)
    • (1980) Stroke , vol.11 , pp. 261-266
    • Shimizu, K.1    Ohta, T.2    Toda, N.3
  • 5
    • 0345140655 scopus 로고
    • Differences between dihydropyridine and non-dihydropyridine calcium antagonists in inotropic, chronotropic, dromotropic and vascular effects: Differences in underlying mechanism.
    • Edited by Fleckenstein, A., Van Breemen, C. and Hoffmeister, F., Springer-Verlag, Berlin
    • Taira, N.: Differences between dihydropyridine and non-dihydropyridine calcium antagonists in inotropic, chronotropic, dromotropic and vascular effects: Differences in underlying mechanism. In Bayer Symposium I.X., Cardiovascular Effects of Dihydropyridine-Type Calcium Antagonists and Agonists, Edited by Fleckenstein, A., Van Breemen, C. and Hoffmeister, F., pp. 370-378, Springer-Verlag, Berlin (1985)
    • (1985) Bayer Symposium I.X., Cardiovascular Effects of Dihydropyridine-Type Calcium Antagonists and Agonists , pp. 370-378
    • Taira, N.1
  • 6
    • 0021134336 scopus 로고
    • Coronary vasodilator compared to cardiac effects of PY 108-068, a new dihydropyridine vasodilator, on isolated, blood-perfused dog-heart preparations.
    • Wada, Y., Satoh, K. and Taira, N.: Coronary vasodilator compared to cardiac effects of PY 108-068, a new dihydropyridine vasodilator, on isolated, blood-perfused dog-heart preparations. J. Cardiovasc. Pharmacol. 6, 881-887 (1984)
    • (1984) J. Cardiovasc. Pharmacol. , vol.6 , pp. 881-887
    • Wada, Y.1    Satoh, K.2    Taira, N.3
  • 7
    • 0023881118 scopus 로고
    • Cardiac versus vascular effects of a new dihydropyridine derivative, CV-4093. In vitro comparison with other calcium antagonists.
    • Nakaya, H., Hattori, Y., Nakao, Y. and Kanno, M.: Cardiac versus vascular effects of a new dihydropyridine derivative, CV-4093. In vitro comparison with other calcium antagonists. Eur. J. Pharmacol. 146, 35-43 (1988)
    • (1988) Eur. J. Pharmacol. , vol.146 , pp. 35-43
    • Nakaya, H.1    Hattori, Y.2    Nakao, Y.3    Kanno, M.4
  • 8
    • 0018927320 scopus 로고
    • Selective abolition of Ca-de-pendent responses of smooth and cardiac muscles by flunarizine.
    • Nakayama, K. and Kasuya, Y.: Selective abolition of Ca-de-pendent responses of smooth and cardiac muscles by flunarizine. Japan. J. Pharmacol. 30, 731-742 (1980)
    • (1980) Japan. J. Pharmacol. , vol.30 , pp. 731-742
    • Nakayama, K.1    Kasuya, Y.2
  • 10
    • 0017684030 scopus 로고
    • Effects of calcium-antagonistic coronary vasodilator on myocardial contractility and membrane potentials.
    • Nabata, H.: Effects of calcium-antagonistic coronary vasodilator on myocardial contractility and membrane potentials. Japan. J. Pharmacol. 27, 239-249 (1977)
    • (1977) Japan. J. Pharmacol. , vol.27 , pp. 239-249
    • Nabata, H.1
  • 11
    • 0023518468 scopus 로고
    • Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones.
    • Fox, A.P., Now'ycky, M.C. and Tsien, R.W.: Kinetic and pharmacological properties distinguishing three types of calcium currents in chick sensory neurones. J. Physiol. (Lond.) 394, 149-172 (1987)
    • (1987) J. Physiol. (Lond.) , vol.394 , pp. 149-172
    • Fox, A.P.1    Now'ycky, M.C.2    Tsien, R.W.3
  • 12
    • 0021069612 scopus 로고
    • Relationship of binding of a calcium channel blocker to Inhibition of contraction in intact cultured embryonic chick ventricular cells.
    • Marsh, J.D., Loh, E., Lachance, D., Barry, W.H. and Smith, T.W.: Relationship of binding of a calcium channel blocker to Inhibition of contraction in intact cultured embryonic chick ventricular cells. Circ. Res. 53, 539-543 (1983)
    • (1983) Circ. Res. , vol.53 , pp. 539-543
    • Marsh, J.D.1    Loh, E.2    Lachance, D.3    Barry, W.H.4    Smith, T.W.5
  • 13
    • 0026378761 scopus 로고
    • Analysis of factors involved in the tissue selectivity of calcium antagonists.
    • Godfraind, T.: Analysis of factors involved in the tissue selectivity of calcium antagonists. Adv. Exp. Med. Biol. 311, 103-122 (1992)
    • (1992) Adv. Exp. Med. Biol. , vol.311 , pp. 103-122
    • Godfraind, T.1
  • 14
    • 0026645447 scopus 로고
    • Mechanisms of pharmacologic intervention at the level of the calcium channel.
    • Fozzard, H.A.: Mechanisms of pharmacologic intervention at the level of the calcium channel. Am. J. Cardiol. 69, 4D-lOD (1992)
    • (1992) Am. J. Cardiol. , vol.69 , pp. 4D-lOD
    • Fozzard, H.A.1
  • 15
    • 0010452459 scopus 로고
    • Nitrendipine block of cardiac calcium channels: High-afffnity binding to the inactivated state.
    • U.S.A.
    • Bean, B.P.: Nitrendipine block of cardiac calcium channels: High-afffnity binding to the inactivated state. Proc. Natl. Acad. Sci. U.S.A. 81, 6388-6392 (1984)
    • (1984) Proc. Natl. Acad. Sci. , vol.81 , pp. 6388-6392
    • Bean, B.P.1
  • 16
    • 0021922721 scopus 로고
    • Effect of membrane depolarization on binding of [3H]nitrendipine to rat cardiac myocytes.
    • Green, F.J., Farmer, B.B., Wiseman, G.L., Jose, M.J.L. and Watanabe, A.M.: Effect of membrane depolarization on binding of [3H]nitrendipine to rat cardiac myocytes. Circ. Res. 56, 576-585 (1985)
    • (1985) Circ. Res. , vol.56 , pp. 576-585
    • Green, F.J.1    Farmer, B.B.2    Wiseman, G.L.3    Jose, M.J.L.4    Watanabe, A.M.5
  • 17
    • 0024466621 scopus 로고
    • Pharmacological properties of voltage-dependent calcium channels in functional microvessels isolated from rat brain.
    • Morel, N. and Godfraind, T.: Pharmacological properties of voltage-dependent calcium channels in functional microvessels isolated from rat brain. Naunyn Schmiedebergs Arch. Pharmacol. 340, 442-451 (1989)
    • (1989) Naunyn Schmiedebergs Arch. Pharmacol. , vol.340 , pp. 442-451
    • Morel, N.1    Godfraind, T.2
  • 18
    • 0025945183 scopus 로고
    • Hydrophobic properties of novel dihydronaphthyridine calcium antagonist and biological activity in porcine isolated cardiac and vascular smooth muscle.
    • Werner, G., Klaus, W., Kojda, G. and Fricke, U.; Hydrophobic properties of novel dihydronaphthyridine calcium antagonist and biological activity in porcine isolated cardiac and vascular smooth muscle. Arch. Pharmacol. 344, 337-344 (1991)
    • (1991) Arch. Pharmacol. , vol.344 , pp. 337-344
    • Werner, G.1    Klaus, W.2    Kojda, G.3    Fricke, U.4
  • 19
    • 0025912736 scopus 로고
    • Molecular diversity of voltage-dependent Ca2+ channels.
    • Tsien, R.W., Ellinor, P.T. and Horn, W.A.: Molecular diversity of voltage-dependent Ca2+ channels. Trends Pharmacol. Sci. 12, 349-354 (1991)
    • (1991) Trends Pharmacol. Sci. , vol.12 , pp. 349-354
    • Tsien, R.W.1    Ellinor, P.T.2    Horn, W.A.3
  • 20
    • 0025343260 scopus 로고
    • Towards an understanding of the dihydropyridine-sensitive calcium channel.
    • McKenna, E., Koch, W.J., Slish, D.F. and Schwartz, A.; Towards an understanding of the dihydropyridine-sensitive calcium channel. Biochem. Pharmacol. 39, 1145-1150 (1990)
    • (1990) Biochem. Pharmacol. , vol.39 , pp. 1145-1150
    • McKenna, E.1    Koch, W.J.2    Slish, D.F.3    Schwartz, A.4
  • 21
    • 0025783198 scopus 로고
    • Vascular protection of lacidipine in salt-loaded Dahl-S rats at nonsustained antihypertensive doses.
    • Cristofori, P., Terron, A., Micheli, D., Bertolini, G., Gaviraghi, G. and Carpi, C.: Vascular protection of lacidipine in salt-loaded Dahl-S rats at nonsustained antihypertensive doses. J. Cardiovasc. Pharmacol. 17, Supp. 4, S75-S86 (1991)
    • (1991) J. Cardiovasc. Pharmacol. , vol.17 , Issue.4 , pp. S75-S86
    • Cristofori, P.1    Terron, A.2    Micheli, D.3    Bertolini, G.4    Gaviraghi, G.5    Carpi, C.6
  • 22
    • 0025875513 scopus 로고
    • Pharmacology of lacidipine, a vascular-selective calcium antagonist.
    • Micheli, D., Ratti, E., Toson, G. and Gaviraghi, G.: Pharmacology of lacidipine, a vascular-selective calcium antagonist. J. Cardiovasc. Pharmacol. 17, Supp. 4, S1-S8 (1991)
    • (1991) J. Cardiovasc. Pharmacol. , vol.17 , Issue.4 , pp. S1-S8
    • Micheli, D.1    Ratti, E.2    Toson, G.3    Gaviraghi, G.4
  • 23
    • 0024464119 scopus 로고
    • Antihypertensive effects of CS-905, a novel dihydropyridine Ca2+ channel Blocker.
    • Oizumi, K., Nishino, H., Koike, H., Sada, T., Miyamoto, M. and Kimura, T.: Antihypertensive effects of CS-905, a novel dihydropyridine Ca2+ channel Blocker. Japan. J. Pharmacol. 51, 57-64 (1989)
    • (1989) Japan. J. Pharmacol. , vol.51 , pp. 57-64
    • Oizumi, K.1    Nishino, H.2    Koike, H.3    Sada, T.4    Miyamoto, M.5    Kimura, T.6
  • 24
    • 0025945754 scopus 로고
    • A comparative in vitro study of transdermal absorption of a series of calcium channel antagonists.
    • Diez, I., Colom, H., Moreno, J., Obach, R., Peraire, C. and Domenech, J.; A comparative in vitro study of transdermal absorption of a series of calcium channel antagonists. J. Pharmaceut. Sci. 80, 931-934 (1991)
    • (1991) J. Pharmaceut. Sci. , vol.80 , pp. 931-934
    • Diez, I.1    Colom, H.2    Moreno, J.3    Obach, R.4    Peraire, C.5    Domenech, J.6
  • 25
    • 0008644638 scopus 로고
    • Lacidipine, a new 1,4-dihydropyridine calcium channel antagonist possessing a potent and long-lasting antihypertensive activity.
    • Edited by Van der Groot, N., Domany, G., Pallos, L. and Timmerman, H., Elsevier, Amsterdam
    • Gaviraghi, G.: Lacidipine, a new 1,4-dihydropyridine calcium channel antagonist possessing a potent and long-lasting antihypertensive activity. In Trends in Medical Chemistry '88, Edited by Van der Groot, N., Domany, G., Pallos, L. and Timmerman, H., pp. 675-690, Elsevier, Amsterdam (1989)
    • (1989) Trends in Medical Chemistry '88 , pp. 675-690
    • Gaviraghi, G.1
  • 26
    • 0026303980 scopus 로고
    • Functional interaction of lacidipine with calcium channels in vascular smooth muscle.
    • Godfraind, T. and Salomone, S.: Functional interaction of lacidipine with calcium channels in vascular smooth muscle. J. Cardiovasc. Pharmacol. 18, Supp. 11, S1-S6 (1991)
    • (1991) J. Cardiovasc. Pharmacol. , vol.18 , Issue.11 , pp. S1-S6
    • Godfraind, T.1    Salomone, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.