Radiotherapy after Breast-Preserving Surgery in Women with Localized Cancer of the Breast

New England Journal of Medicine

Volumn 328, Issue 22, 1993, Pages 1587-1591

  Veronesi, Umberto ^a   Luini, Alberto ^b   Del Vecchio, Marcella ^b   Greco, Marco ^b   Galimberti, Viviana ^b   Merson, Mirella ^b   Rilke, Franco ^b   Sacchini, Virgilio ^b   Saccozzi, Roberto ^b   Savio, Tommaso ^b   Zucali, Roberto ^b   Zurrida, Stefano ^b   Salvadori, Bruno ^b  

^a NATIONAL CANCER INSTITUTE   (Italy)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

TAMOXIFEN;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER ADJUVANT THERAPY; CANCER LOCALIZATION; CANCER RADIOTHERAPY; CANCER SIZE; CANCER STAGING; CANCER SURVIVAL; DISSEMINATED CANCER; FEMALE; HUMAN; HUMAN TISSUE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; SECOND CANCER; SEGMENTAL MASTECTOMY; SURGICAL TECHNIQUE;

BREAST NEOPLASMS; CARCINOMA, INTRADUCTAL, NONINFILTRATING; CHEMOTHERAPY, ADJUVANT; COMBINED MODALITY THERAPY; COMPARATIVE STUDY; FEMALE; FOLLOW-UP STUDIES; HUMAN; LIFE TABLES; LYMPH NODE EXCISION; MASTECTOMY, SEGMENTAL; MIDDLE AGE; NEOPLASM RECURRENCE, LOCAL;

EID: 0027233530     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJM199306033282202     Document Type: Article

References (19)

1. Veronesi U, Saccozzi R, Del Vecchio M, Comparing radical mastectomy with quadrantectomy, axillary dissection, and radiotherapy in patients with small cancers of the breast. N Engl J Med 1981; 305:6-11
2. Sarrazin D, Le MG, Fontaine MF, Arriagada R. Conservative treatment versus mastectomy in T1 or small T2 breast cancer – a randomized clinical trial. In: Harris JR, Hellman S, Silen W, eds. Conservative management of breast cancer: new surgical and radiotherapeutic techniques. Philadelphia: J.B. Lippincott, 1983:101-11.
3. Fisher B, Bauer M, Margolese R, Five-year results of a randomized clinical trial comparing total mastectomy and segmental mastectomy with or without radiation in the treatment of breast cancer. N Engl J Med 1985; 312:665-673
4. van Dongen JA, Bartelink H, Fentiman IS, et al. Randomized clinical trial to assess the value of breast-conserving therapy in stage I and II breast cancer, EORTC 10801 trial. In: National Institutes of Health Consensus Development Conference on the Treatment of Early-Stage Breast Cancer. NCI monographs. No. 11. Washington, D.C.: Government Printing Office, 1992:15-8. (NIH publication no. 90-3187.)
5. Veronesi U, Volterrani F, Luini A, Quadrantectomy versus lumpectomy for small size breast cancer. Eur J Cancer 1990; 26:671-673
6. Stewart HJ, Prescott RJ, Forrest PA Conservation therapy of breast cancer. Lancet 1989; 2:168-169
7. Ribeiro GG, Dunn G, Swindell R, Harris M, Banerjee SS Conservation of the breast using two different radiotherapy techniques: interim report of a clinical trial. Clin Oncol (R Coll Radiol) 1990; 2:27-34
8. The Uppsala-Orebro Breast Cancer Study Group. Sector resection with or without postoperative radiotherapy for stage I breast cancer: a randomized trial. J Natl Cancer Inst 1990; 82:277-280
9. Kalbfleisch JD, Prentice RL. The statistical analysis of failure time data. New York: John Wiley, 1980.
10. Kaplan EL, Meier P Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958; 53:457-481
11. Harris JR, Connolly JL, Schnitt SJ, The use of pathologic features in selecting the extent of surgical resection necessary for breast cancer patients treated by primary radiation therapy. Ann Surg 1985; 201:164-169
12. Veronesi U, Salvadori B, Luini A, Conservative treatment of early breast cancer: long-term results of 1232 cases treated with quadrantectomy, axillary dissection, and radiotherapy. Ann Surg 1990; 211:250-259
13. Schnitt SJ, Connolly JL, Recht A, Silver B, Harris JR Breast relapse following primary radiation therapy for early breast cancer. II. Detection, pathologic features and prognostic significance. Int J Radiat Oncol Biol Phys 1985; 11:1277-1284
14. Solin LJ, Fowble BL, Schultz DJ, Goodman RL The significance of the pathology margins of the tumor excision on the outcome of patients treated with definitive irradiation for early stage breast cancer. Int J Radiat Oncol Biol Phys 1991; 21:279-287
15. Fourquet A, Campana F, Zafrani B, Prognostic factors of breast recurrence in the conservative management of early breast cancer: a 25-year follow-up. Int J Radiat Oncol Biol Phys 1989; 17:719-725
16. Chauvet B, Reynaud-Bougnoux A, Calais G, Prognostic significance of breast relapse after conservative treatment in node-negative early breast cancer. Int J Radiat Oncol Biol Phys 1990; 19:1125-1130
17. Chu AM, Cope O, Russo R, Lew R Patterns of local-regional recurrence and results in stages I and II breast cancer treated by irradiation following limited surgery. Am J Clin Oncol 1984; 7:221-229
18. Rose MA, Henderson IC, Gelman R, Premenopausal breast cancer patients treated with conservative surgery, radiotherapy and adjuvant chemotherapy have a low risk of local failure. Int J Radiat Oncol Biol Phys 1989; 17:711-717
19. Fisher B, Redmond C. Lumpectomy for breast cancer: an update of the NSABP experience. In: National Institutes of Health Consensus Development Conference on the Treatment of Early-Stage Breast Cancer. NCI monographs. No. 11. Washington, D.C.: Government Printing Office, 1991:7-13. (NIH publication no. 90-3187.)