-
2
-
-
0025080333
-
Identification of Haematopoietic Progenitor Cells of Macrophages or Dendritic/Langerhans' Cells (DL-cfu) in Human Bone Marrow or Peripheral Blood
-
(1990)
Blood
, vol.76
, pp. 1139-1149
-
-
Reid1
Fryer2
Clifford3
Kirk4
Knight5
-
3
-
-
0026702360
-
+ Progenitors in Human Bone Marrow
-
+ Studies of single progenitor cells indicate that these precursors have a capacity for both macropahge and DC differentiation. Using serum-free medium, granulocyte-macrophage colony-stimulating factor and TNF are defined as the essential reqirements for growth from stem cells.
-
(1992)
J Immunol
, vol.149
, pp. 2681-2688
-
-
Reid1
Stackpoole2
Meager3
Tikerpae4
-
4
-
-
0026579716
-
Identification of Proliferation Dendritic Cell Precursors in Mouse Blood
-
+ stem cells from human cord blood. It relies on the evidence that granulocyte-macropahge colony-stimulating factor and TNF are required growth factors. Other papers use similar conditions for growth of DCs from mouse blood [4•] and mouse bone marro [5••,6•].
-
(1992)
J Exp Med
, vol.175
, pp. 1157-1167
-
-
Inaba1
Steinman2
Witmer Pack3
Aya4
Inaba5
Sudo6
Walpe7
Schuler8
-
5
-
-
0026481133
-
Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor
-
+ stem cells from human cord blood. It relies on the evidence that granulocyte-macropahge colony-stimulating factor and TNF are required growth factors. Other papers use similar conditions for growth of DCs from mouse blood [4•] and mouse bone marro [5••,6•].
-
(1992)
Journal of Experimental Medicine
, vol.176
, pp. 1693-1702
-
-
Aya1
Deguchi2
Ikehara3
Muramatsu4
Steinman5
-
6
-
-
0026793113
-
Dendritic Cells from Mouse Bone-Marrow: in Vitro Differentiation Using Low Doses of Recombinant Granulocyte-Macrophage Colony Stimulating Factor
-
+ stem cells from human cord blood. It relies on the evidence that granulocyte-macropahge colony-stimulating factor and TNF are required growth factors. Other papers use similar conditions for growth of DCs from mouse blood [4•] and mouse bone marro [5••,6•].
-
(1992)
J Immunol Methods
, vol.154
, pp. 253-264
-
-
Scheicher1
Mehug2
Zecher3
Reske4
-
7
-
-
0026446156
-
GM-CSF and TNF-a Co-operate in the Generation of Dendritic Langerhans' Cells
-
+ stem cells from human cord blood. It relies on the evidence that granulocyte-macropahge colony-stimulating factor and TNF are required growth factors. Other papers use similar conditions for growth of DCs from mouse blood [4 of special interest] and mouse bone marrow [5 of outstanding interest,6 of special interest].
-
(1992)
Nature
, vol.360
, pp. 258-261
-
-
Caux1
Dezutter-Dambuyant2
Schmi3
Banchereau4
-
8
-
-
0026512117
-
Development of a Langerhans' Cell Phenotype from Peripheral Blood Monocytes
-
(1992)
Immunol Lett
, vol.31
, pp. 189-198
-
-
Rossi1
-
9
-
-
0025733033
-
Morphology and Phenotype of Dendritic Cells from Peripheral Blood and Productive and Non-productive Infection with Human Immunodeficiency Virus Type 1
-
of outstanding interest, Dendritic cells from 24 hour cultures of peripheral blood mononuclear cells were identified from morphology and phenotype using immunogold labelling and electron microscopy. A series of cell types probably reflecting different stages of life-history was identified with small numbers of cells having blunter pseudopods (reminiscent of LCs) and a few with a very veiled/interdigitating cell type of morphology. Productive infection with HIV-1 was only seen with these two possibly more mature morphologies.
-
(1991)
Immunology
, vol.72
, pp. 361-367
-
-
Patterson1
Gross2
Bedford3
Knight4
-
11
-
-
0026603367
-
The MRC OX-62 Antigen: A Useful Marker in the Purification of Rat Veiled Cells with the Biochemical Properties of an Integrin
-
of special interest, A mouse anti-rat antibody staining a proportion of rat veiled (dendritic) cells was produced. This antibody precipitated material with the characteristics of an integrin and labelled the a-like subunit.
-
(1992)
J Exp Med
, vol.175
, pp. 1457-1465
-
-
Brenan1
Pukiavel2
-
17
-
-
0026775970
-
Processing and Presentation of Intact Hen Egg Lysozyme by Dendritic Cells
-
of special interest, Conflicting reports exist regarding the capacity of DCs to process large antigens. Here H-2k dendritic cells are shown to process and present intact hen egg-white Lyozyme, requiring 100 times less antigen than B-cell blasts for effective presentation.
-
(1992)
Eur J Immunol
, vol.22
, pp. 2347-2352
-
-
De Bruijn1
Nieland2
Harding3
Melief4
-
19
-
-
0021672885
-
Veiled Cells - ‘Dendritic Cells’ of the Peripheral Lymph
-
(1984)
Immunology
, vol.168
, pp. 349-361
-
-
Knight1
-
22
-
-
0026507383
-
Dermal Tumour Necrosis Factorα Induces Dendritic Cell Migration to Draining Lymph Nodes, and Possibly Provides One Stimulus for Langerhans' Cell Migration
-
(1992)
Immunology
, vol.75
, pp. 257-263
-
-
Cumberbatch1
Kimber2
-
23
-
-
0026664088
-
The Immunologic Properties of Epidermal Langerhans' Cells as a Part of the Dendritic Cell System
-
(1992)
Immunopathology
, vol.13
, pp. 265-279
-
-
Romani1
Schuler2
-
24
-
-
0026714743
-
Heterogeneity in Antigen Processing by Different Types of Antigen-presenting Cells. Effect of Cell Culture on Antigen Processing Ability
-
of special of interest, Reports that different epitopes of ovalbumin appear to be processed independently and differentially by B cells and by spleen cells. The precise peptides produced may also vary with the physiological state of the antigen-presenting cells.
-
(1992)
J Immunol
, vol.149
, pp. 1905-1911
-
-
Vidard1
Rock2
Benacerraf3
-
25
-
-
0026571275
-
Differential Sensitivity of Freshly Isolated and Cultured Murine Langerhans' Cells to UltravioletB Radiation and Chemical Fixation
-
(1992)
Eur J Immunol
, vol.22
, pp. 581
-
-
Tang1
Udey2
-
26
-
-
0026073427
-
Murine Epidermal Antigenpresenting Cells in Primary and Secondary T-cell Proliferative Responses to Herpes Simplex Virus in Vitro
-
(1992)
Immunotlogy
, vol.72
, pp. 34-39
-
-
Williams1
Hill2
Hooper3
-
29
-
-
0026712321
-
Functional Expression of the Costimulatory Molecule, B7/BB1, on Murine Dendritic Cell Populations
-
of outstanding interest, This, together with [29•,30•], emphasises the importance of B7/BB1 and CD28 in activation of T cells by DCs. In this particular example evidence that this interaction is important in the maintenance of T-cell competence is combined with evidence that blocking this interaction can result in a state of T-cell hyporeponsiveness.
-
(1992)
J Exp Med
, vol.176
, pp. 1215-1220
-
-
Larsen1
Ritchie2
Pearson3
Linsley4
Lowry5
-
30
-
-
0026686163
-
+ Lympho cytes by Human Blood Dendritic Cells in Vitro
-
of outstanding interest, This, together with [29•,30•], emphasises the importance of B7/BB1 and CD28 in activation of T cells by DCs. In this particular example evidence that this interaction is important in the maintenance of T-cell competence is combined with evidence that blocking this interaction can result in a state of T-cell hyporeponsiveness.
-
(1992)
J Clin Invest
, vol.90
, pp. 229-237
-
-
Young1
Koulova2
Soergel3
Clark4
Steinman5
Dupon6
-
31
-
-
0027397169
-
Induction of Alloantigen-specific Hyporesponsiveness in Human T Lymphocytes by Blocking Interaction of CD28 with Its Natural Ligand B7/BB1
-
of outstanding interest, This, together with [29•,30•], emphasises the importance of B7/BB1 and CD28 in activation of T cells by DCs. In this particular example evidence that this interaction is important in the maintenance of T-cell competence is combined with evidence that blocking this interaction can result in a state of T-cell hyporeponsiveness.
-
(1993)
J Exp Med
, vol.177
, pp. 165-173
-
-
Tan1
Anasetti2
Hansen3
Melrose4
Brunvard5
Bradshaw6
Ledbetter7
Linsley8
-
32
-
-
0026715045
-
Cytokine Gene Expression in Murine Epidermal Cell Suspensions: Interleukin 1β and Macrophage Inflammatory Protein la Are Selectively Expressed in Langerhans Cells but Are Differentially Regulated in Culture
-
of special interest
-
(1992)
J Exp Med
, vol.176
, pp. 1221-1226
-
-
Heufler1
Toper2
Koch3
Trockenbacher4
Kampgen5
Romani6
Schuler7
-
36
-
-
0026456714
-
Mechanisms of Induction of Primary Virus-specific Cytotoxic Lymphocyte-T Responses
-
of special interest, Dendritic cells and RMA-S lymphoma cells were the only antigen-presenting cells shown to stimulate primary cytotoxic T-cell responses but by divergent mechanisms. Dendritic cells presented either viral peptide or processed infectious virus but RMA-S cells presented only exogenous viral peptide and the latter required much higher quantities of antigen.
-
(1992)
Eur J Immunol
, vol.22
, pp. 3113
-
-
de Bruijn1
Nieland2
Schumacher3
Ploegh4
Kast5
Melief6
-
37
-
-
0026585493
-
Soluble Proteins Delivered to Dendritic Cells via pH Sensitive Liposomes Induce Primary Cytotoxic T Lymphocyte Responses in Vitro
-
(1992)
J Exp Med
, vol.175
, pp. 609-612
-
-
Nair1
Zhou2
Reddy3
Huang4
Rouse5
-
38
-
-
0026037261
-
Primary Prolifera tive and Cytotoxic Responses to HIV Induced in Vitro by Human Dendritic Cells
-
of outstanding interest, Primary stimulation with antigen-pulsed DCs using cells from donors not infected with HIV-1 and who are not, therefore, immunocompromised were used to identify a small peptide that is a T-cell epitope. In individuals of different MHC types, it initiated production of cytotoxic T cells that killed virus-infected target cells. This approach shows the efficiency of DCs in primary stimulation and should identify peptides with protective potential for vaccination purposes.
-
(1991)
Immunology
, vol.74
, pp. 407-413
-
-
MacAtonia1
Patmrson2
Knight3
-
39
-
-
0027213233
-
Primary human T-cell responses to the major outer membrane protein of Chlamydia trachomatis.
-
of special interest, in press, Primary proliferative T-cell responses and interferon γ production were produced using DCs pulsed with recombinant fragments of major outer membrane of Chlamydia tracbomatis One T-cell epitope of 12 amino acids was shown to stimulate responses in cells from 80 per cent of donors. This approach may be useful for vaccine development.
-
(1993)
Immunology
-
-
Stagg1
Elsley2
Ward3
Knight4
-
49
-
-
0026688409
-
Inefficient Positive Selection of T Cells Directed by Haematopoietic Cells
-
(1992)
Nature
, vol.359
, pp. 330-333
-
-
Bix1
Raulet2
-
52
-
-
0026509260
-
Capacity of Antigen Uptake by B Cells, Fibroblasts or Macrophages Determines Efficiency of Presentation of a Soluble Self Antigen (C5) to Lymphocyte
-
(1992)
Eur J Immunol
, vol.22
, pp. 1271-1278
-
-
Stockinger1
-
55
-
-
0026559329
-
Cells that Present Both Ligand and Costimulatory Activity Are the Most Efficient inducers of Clonal Expansion of Normal CD4 T Cells
-
of outstanding interest, Delivery of a ligand plus a co-stimulatory molecule, two neceassary signals for clonal expansion of T cells, was achieved either on a single cell or on two separate cells. Delivery of both signals on one cell appeared to be at least 30 times more efficient than separate delivery of the signals. The authors speculate that this could explain why tissues can express autoantigens and contain antigen-presenting cells without inducing autoimmunity.
-
(1992)
Proc Natl Acad Sci USA
, vol.89
, pp. 3845-3849
-
-
Liu1
Janeway2
-
57
-
-
0026604062
-
Cultured Human Follicular Dendritic Cells - Growth Characteristics and Interactions with Lymphocytes
-
(1992)
J Immunol
, vol.148
, pp. 3327-3335
-
-
Clark1
Grabstein2
Shu3
-
58
-
-
0026528275
-
Follicular Dendritic Celldependent Adhesion and Proliferation of B Cells in Vitro
-
(1992)
J Immunol
, vol.148
, pp. 2331-2339
-
-
Kosco1
Pflugfelder2
Gray3
-
59
-
-
0023521281
-
Localization of Antigen on Lymph Node Dendritic Cells After Exposure to the Contact Sensitizer Fluorescein Isothio cyanate Functional and Morphological Studies
-
(1987)
J Exp Med
, vol.166
, pp. 1654-1667
-
-
MacAtonia1
Knight2
Edwards3
Griffiths4
Fryer5
-
63
-
-
0026459253
-
Effect of Class I MHC-binding Peptides on Recognition by Natural Killer Cells
-
of special interest, Normal cells are lysed on incubation with IL-2 activated NK cells if peptides that can bind to the MHC class I molecules of the normal cells are also included in the assay.
-
(1992)
J Immunol
, vol.149
, pp. 3150-3156
-
-
Chadwick1
Samhara2
Sasakura3
Miller4
-
65
-
-
0026555698
-
Inhibition of Class I and Class II MHC-restricted Antigen Presentation by Cytotoxic T Lymphocytes Specific for an Exogenous Antigen
-
of special interest, MHC restricted, CD8+ cells cause inhibition of antigen presentation in the presence of the antigen recognized by the cytotoxic T cells present. The paper indicates that when antigen-presenting cells present antigen to cytotoxic cells they are inhibited or killed.
-
(1992)
J Immunol
, vol.148
, pp. 3028-3033
-
-
Rock1
Rothstein2
Fleischacker3
Gamble4
-
67
-
-
0026500111
-
Follicular Dendritic Cells and Their Role in HIV Infection
-
(1992)
Immunol Today
, vol.13
, pp. 81-83
-
-
Gerdes1
Flad2
-
68
-
-
0026720985
-
Immunosuppression by lymphocytic choriomeningitis virus infection: competent effector T and B cells but impaired antigen presentation
-
of special interest, Antigen presentation was severely impaired both histologically and functionally in lymphocytic choriomeningitis virus-immunosuppressed mice, although T and B cells were able to function in the normal range.
-
(1992)
European Journal of Immunology
, vol.22
, pp. 1803-1812
-
-
Althage1
Odermatt2
Moskophidis3
Kundig4
Hoffmanrohrer5
Hengartner6
Zinkernagel7
-
69
-
-
0025787430
-
Virus-triggered Acquired Immunodeficiency by Cytotoxic T Cell-dependent Destruction of Antigen-presenting Cells and Lymph Follicle Structure
-
of special interest, Immunosuppression induced by virus is shown to result following T cell dependent destruction of macropahges and DCs. A role for these cells in maintaining follicular structure is also suggested as severe destruction of follicular integrity results.
-
(1991)
Proc Natl Acad Sci USA
, vol.88
, pp. 8252-8256
-
-
Odermatt1
Eppler2
Leist3
Hengartner4
Zinkernagel5
-
71
-
-
0026683758
-
− Lymphocytes to a Microbial Antigen
-
of special interest, Evidence is presented for the antigen-presenting function of CDlb molecules, suggesting that the CD1 family plays a role in cell-mediated immunity to microbial pathogens.
-
(1992)
Nature
, vol.360
, pp. 593-597
-
-
Porcelli1
Morita2
Brenner3
-
79
-
-
0023691863
-
Killing of Antigen Reactive B Cells by Class II-restricted, Soluble Antigen-specific CD8+ Cytolytic T Lymphocytes
-
(1988)
Nature
, vol.336
, pp. 481-484
-
-
Shinohara1
Watanabe2
Sacho3
Hozumi4
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