The effects of recombinant insulin-like growth factor I administration on growth hormone levels and insulin requirements in adolescents with Type 1 (insulin-dependent) diabetes mellitus

Diabetologia

Volumn 36, Issue 7, 1993, Pages 678-681

  Cheetham, T D ^a   Jones, J ^b   Taylor, A M ^b   Holly, J ^c   Matthews, D R ^d   Dunger, D B ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c ST BARTHOLOMEW S HOSPITAL   (United Kingdom)

^d RADCLIFFE INFIRMARY   (United Kingdom)

Author keywords

adolescence; growth hormone; insulin requirements; insulin like growth factor I; Type 1 (insulin dependent) diabetes mellitus

Indexed keywords

GLUCOSE; GROWTH HORMONE; INSULIN; RECOMBINANT SOMATOMEDIN C;

ADOLESCENT; ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; INSULIN DEPENDENT DIABETES MELLITUS; MALE; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION;

ADOLESCENT; BLOOD GLUCOSE; DIABETES MELLITUS, INSULIN-DEPENDENT; DOUBLE-BLIND METHOD; FEMALE; GLUCOSE CLAMP TECHNIQUE; GROWTH HORMONE; HUMAN; INSULIN; INSULIN-LIKE GROWTH FACTOR I; MALE; PLACEBOS; RECOMBINANT PROTEINS;

EID: 0027230860     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/BF00404081     Document Type: Article

References (10)

1. Increased overnight growth hormone concentrations in diabetic compared with normal adolescents
2. Changes in growth hormone concentrations during puberty in adolescents with insulin dependent diabetes
3. Characterization of the insulin-antagonistic effect of growth hormone in man
4. Contrasting metabolic effects of continuous and pulsatile growth hormone administration in young adults with type 1 (insulin-dependent) diabetes mellitus
5. Nocturnal spikes of growth hormone secretion cause the dawn phenomenon in type 1 (insulin-dependent) diabetes mellitus by decreasing hepatic (and extrahepatic) sensitivity to insulin in the absence of insulin waning
6. Impact of increased growth hormone secretion on carbohydrate metabolism in adolescents with diabetes
7. Effect of diabetes and its control on insulin-like growth factors in the young subject with type 1 diabetes
8. Somatomedin-C/IGF-1 measured by radioimmunoassay and somatomedin bioactivity in adolescents with insulin dependent diabetes compared with puberty matched controls
9. An unbiased glucose clamp method using a variable insulin infusion: its application in diabetic adolescents
10. Pharmacokinetic profile of recombinant human insulin-like growth factor 1 subcutaneously in normal subjects