Investigations into the Adenosine Outflow from Hippocampal Slices Evoked by Ischemia‐Like Conditions

Journal of Neurochemistry

Volumn 61, Issue 1, 1993, Pages 284-289

  Pedata, Felicita ^a   Latini, Serena ^a   Pugliese, Anna Maria ^a   Pepeu, Giancarlo ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

Adenosine outflow; Excitatory amino acids; Hippocampal slices; Inosine outflow; Ischemia

Indexed keywords

2 AMINO 7 PHOSPHONOHEPTANOIC ACID; 6,7 DINITRO 2,3 QUINOXALINEDIONE; 8 PHENYLTHEOPHYLLINE; ADENOSINE; ALPHA,BETA METHYLENEADENOSINE DIPHOSPHATE; DIHYDROKAINIC ACID; EXCITATORY AMINO ACID; GUANOSINE PHOSPHATE; INOSINE; TETRODOTOXIN;

AMINO ACID ANALYSIS; ANIMAL MODEL; ARTICLE; BRAIN ELECTROPHYSIOLOGY; BRAIN ISCHEMIA; BRAIN SLICE; CONTROLLED STUDY; ELECTROSTIMULATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; MALE; METABOLIC REGULATION; NEUROCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; RAT;

5'-NUCLEOTIDASE; ADENOSINE; AMINO ACIDS; ANIMAL; BRAIN ISCHEMIA; CALCIUM; ELECTRIC STIMULATION; ELECTROPHYSIOLOGY; HIPPOCAMPUS; IN VITRO; INOSINE; MALE; RATS; RATS, WISTAR; SUPPORT, NON-U.S. GOV'T; TETRODOTOXIN;

EID: 0027230731     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.1993.tb03566.x     Document Type: Article

References (32)

1. Effect of propentofylline (HWA 285) on extracellular purine and excitatory amino acids in CA, of rat hippocampus during transient ischemia
2. Adenosine‐containing neurons in the brain localized by immunochemistry
3. Serotonin blocks the long‐term potentiation induced by primed burst stimulation in the CA1 region of rat hippocampal slices
4. Protective effect of adenosine and a novel xanthine derivative propentofylline on the cell damage after bilateral carotid occlusion in the gerbil hippocampus
5. Adenosine antagonists delay hypoxia‐induced depression of neuronal activity in hippocampal brain slices
6. Adenosine antagonists alter the synaptic response to in vitro ischemia in the rat hippocampus
7. Levels of adenosine and adenine nucleotides in slices of rat hippocampus
8. The adenosine antagonist 8‐cyclopentyltheophylline reduces the depression of hippocampal neuronal responses during hypoxia
9. Blockade of N‐methyl‐d aspartate‐sensitive acidic amino acid receptors inhibits ischemia‐induced accumulation of purine catabolites in the rat striatum
10. Effects of anoxia on ion distribution in the brain
11. +‐ and glutamate‐evoked release of endogenous adenosine from rat cortical slices
12. Glutamate‐evoked release of endogenous adenosine from rat cortical synaptosomes is mediated by glutamate uptake and not by receptors
13. N‐methyl‐d‐aspartate, kainate, and quisqualate release endogenous adenosine from rat cortical slices
14. Extracellular accumulation of glutamate in the hippocampus induced by ischemia is not calcium dependent: in vitro and in vivo evidence
15. Release of purines, noradrenaline, and GABA from rat hippocampal slices by field stimulation
16. Nonsynaptic epileptogenesis in the mammalian hippocampus in vitro. I. Development of seizure‐like activity in low extracellular calcium
17. + and veratridine
18. Oxygen‐derived free radicals in postischemic tissue injury
19. Adenosine production and metabolism
20. Sites of adenosine formation, action, and inactivation in the brain
21. Adenosine formation and release by embryonic chick neurons and glia in cell culture
22. Protective effect of adenosine on the anoxic damage of hippocampal slice
23. Critical evaluation of the role of ecto‐ and cytosolic 5′‐nucleotidase in adenosine formation
24. Muscarinic modulation of purine release from electrically stimulated rat cortical slices
25. Regional differences in the electrically stimulated release of endogenous and radioactive adenosine and purine derivatives from rat brain slices
26. Endogenous adenosine release from hippocampal slices: excitatory amino acid agonists stimulate release; antagonists reduce the electrically evoked release
27. Excitatory amino acid release and free radical formation may cooperate in the genesis of ischemia‐induced neuronal damage
28. NMDA receptor activation accelerates ischemic energy depletion in the hippocampal slice and the demonstration of a threshold for ischemic damage to protein synthesis
29. 2+‐independent release of glutamate during anoxia in isolated nerve terminals (synaptosomes)
30. An “in vitro” model of ischemia: metabolic and electrical alterations in the hippocampal slice
31. Adenosine measurement by a rapid HPLC‐fluorometric method: induced changes of adenosine content in regions of rat brain
32. Effect of anoxia and recovery on the neurotransmission and level of high‐energy phosphates in thin hippocampal slices from the guinea pig