Correlation of metabolism, covalent binding and toxicity for a series of bromobenzene derivatives using rat liver slices in vitro

Chemico-Biological Interactions

Volumn 88, Issue 2-3, 1993, Pages 191-208

  Fisher, Robyn ^a   Brendel, Klaus ^b   Hanzlik, Robert P ^b  

^a UNIVERSITY OF ARIZONA   (United States)

^b UNIVERSITY OF KANSAS   (United States)

Author keywords

Bromobenzene; Covalent binding; Hepatotoxicity; Liver slices; Metabolism; o Bromoanisole; o Bromobenzonitrile; o Bromotoluene; o Dibromobenzene

Indexed keywords

BENZENE DERIVATIVE; BROMOBENZENE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COVALENT BOND; LIVER SLICE; LIVER TOXICITY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; XENOBIOTIC METABOLISM;

ANIMAL; BROMOBENZENES; COMPARATIVE STUDY; IN VITRO; LIVER; MALE; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027227702     PISSN: 00092797     EISSN: None     Source Type: Journal    
DOI: 10.1016/0009-2797(93)90091-C     Document Type: Article

References (52)

1. Possible mechanism of liver necrosis caused by aromatic organic compounds
2. 3-Methylcholanthrene blocks hepatic necrosis induced by administration of bromobenzene or carbon tetrachloride
3. Bromobenzene metabolism and hepatic necrosis
4. Bromobenzene-induced hepatic necrosis: species differences and protection by SKF 525-A
5. Role of detoxifying enzymes in bromobenzene-induced liver necrosis
6. Biliary excretion of metabolities of bromobenzene
7. Stereoselective formation of bromobenzene glutathione conjugates
8. Metabolic activation and hepatotoxicity — metabolism of bromobenzene in isolated hepatocytes
9. Metabolic activation and hepatotoxicity — toxicity of bromobenzene in hepatocytes isolated from phenobarbital- and diethylmaleate-treated rats
10. Mechanisms of cell injury in the killing of cultured hepatocytes by bromobenzene
11. Centrolobular hepatic necrosis related to covalent binding of metabolites of halogenated aromatic hydrocarbons
12. Bromobenzene-induced liver necrosis, protective role of glutathione and evidence for 3,4-bromobenzene oxide as the hepatotoxic metabolite
13. Effect of substituents on arene oxide-mediated liver toxicity among substituted bromobenzenes
14. Effect of substituents on in vitro metabolism and covalent binding of substituted bromobenzenes
15. In vitro metabolism and covalent binding among ortho-substituted bromobenzenes of varying hepatotoxicity
16. Toxicity of ortho-substituted bromobenzenes to isolated hepatocytes: comparison to in vivo results
17. In vitro cytotoxicity of allyl alcohol and bromobenzene in a novel organ culture system
18. Toxicity of ortho-substituted bromobenzenes in rat liver slices: a comparison to isolated hepatocytes and the whole animal
19. 14C]-bromobenzene, evidence for quinones as reactive metabolites
20. 14C]-aniline
21. Chromatographic resolution of amino acid adducts of aliphatic halides
22. A new instrument for the rapid preparation of tissue slices
23. Toxicity of chlorobenzenes in cultured rat liver slices
24. Metabolism of dichlorobenzenes in organ cultured liver slices
25. The contribution of bromobenzene to our current understanding of chemically-induced toxicities
26. Metabolic activation and protein covalent binding chemistry of bromobenzene and derivatives
27. Enzymatic activation of chemicals to toxic metabolites
28. N-Dealkylation of tertiary amides by cytochrome P-450
29. Mechanisms of catechol formation from aromatic compounds in isolated rat hepatocytes
30. Identification of epoxide- and quinone-derived bromobenzene adducts to protein sulfur nucleophiles
31. Dihydroxylated mercapturic acid metabolites of bromobenzene
32. The metabolism and excretion of mononitrotoluenes by Fischer 344 rats
33. 2-Chlorotoluene metabolism by rats
34. Mercapturic acids as metabolites of aromatic aldehydes and alcohols
35. Effect of chronic ethanol administration on bromobenzene liver toxicity in the rat
36. 14C-bromobenzene catalysed by rat liver microsomes
37. Bromobenzene and p-bromophenol toxicity and covalent binding in vivo
38. Liver glutathione depletion induced by bromobenzene, iodobenzene, and diethyimaleate poisoning and its relation to lipid peroxidation and necrosis
39. Comparison of the effects of metals on cellular injury and lipid peroxidation in isolated rat hepatocytes
40. Paracetamol toxicity in isolated rat hepatocytes
41. Effects of diphenyl-phenylenediamine on gentamicin-induced lipid peroxidation and toxicity in rat renal cortex
42. Toxic drug effects associated with oxygen metabolism: redox cycling and lipid peroxidation
43. Free-radical mechanisms in tissue injury
44. Interrelationship between lipid peroxidation and other hepatotoxic events
45. The effects of bromobenzene and carbon tetrachloride exposure in vitro on the phospholipase C activity of rat liver cells
46. The role of phospholipid metabolism in bromobenzene- and carbon tetrachloride-dependent hepatocyte injury
47. Menadione-induced bleb formation in hepatocytes associated with the oxidation of thiol groups in actin
48. 2+ in toxic cell killing
49. Effect of sodium selenite upon bromobenzene toxicity in rats: hepatotoxicity
50. Effect of sodium selenite upon bromobenzene toxicity in rats: metabolism
51. Antagonism of bromobenzene-induced hepatotoxicity by the α-adrenergic blocking agents, phentolamine and idazoxan
52. Redox cycling and sulphydryl arylation: their relative importance in the mechanism of quinone cytotoxicity to isolated hepatocytes