Pharmacokinetics of morphine infusion in premature neonates

Archives of Disease in Childhood

Volumn 69, Issue 1 SUPPL., 1993, Pages 55-58

  Hartley, R ^a   Green, M ^a   Quinn, M ^a   Levene, M I ^a  

^a UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

MORPHINE;

ARTICLE; CLINICAL ARTICLE; CONTINUOUS INFUSION; DRUG EFFICACY; DRUG SAFETY; DRUG USE; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; MALE; MEAN ARTERIAL PRESSURE; NEWBORN; PREMATURITY; PRIORITY JOURNAL; RIGIDITY; SIDE EFFECT;

EID: 0027224052     PISSN: 00039888     EISSN: None     Source Type: Journal    
DOI: 10.1136/adc.69.1_spec_no.55     Document Type: Article

References (19)

1. Elias-Jones, A.C.; Barrett, D.A.; Rutter, N.; Shaw, P.N.; Davis, S.S. Diamorphine infusion in the preterm infant Arch Dis Child 1991 10.1136/adc.66.10_Spec_No.1155 66 1155
2. Quinn, M.W.; Otoo, F.; Rushforth, J.A. Effect of morphine and pancuronium on the stress response in ventilated preterm infants Early Hum Dev 1992 10.1016/0378-3782(92)90073-P 30 241
3. Greenough, A.; Morley, C.J.; Wood, S.; Davis, J.A. Pancuronium prevents pneumothoraces in ventilated premature babies who actively expire against positive pressure inflation Lancet 1984 10.1016/S0140-6736(84)90177-6 i: 1
4. Osborne, R.; Joel, S.; Trew, D.; Slevin, M. Morphine and metabolite behaviour after different routes of morphine administration: demonstration of the importance of the active metabolite morphine-6-glucuronide Clin Pharmacol Ther 1990 10.1038/clpt.1990.2 47 12
5. Hasselstrom, J.; Berg, U.; Lofgren, A.; Sawe, J. Long lasting respiratory depression induced by morphine-6-glucuronide? BrJ Clin Pharmacol 1989 10.1111/j.1365-2125.1989.tb05401.x 27 515
6. Smith, M.T.; Watt, J.A.; Cramond, T. Morphine-3-glucuronide-a potent antagonist of morphine analgesia Life Sci 1990 10.1016/0024-3205(90)90619-3 47 579
7. Watt, J.A.; Cramond, T.; Smith, M.T. Morphine-6glucuronide: analgesic effects antagonized by morphine3-glucuronide. Clin Exp PharmacolPhysiol 1990 83
8. Gong, Q.-L.; Hedner, T.; Hedner, J.; Bjorkman, R.; Nordberg, G. Antinociceptive and ventilatory effects of the morphine metabolites: morphine-6-glucuronide and morphine-3glucuronide EurJPharmacol 1991 193 47
9. Choonara, I.A.; McKay, P.; Hain, R.; Rane, A. Morphine metabolism in children BrJClin Pharmacol 1989 28 599
10. Mercurio, M.; Nelli, C.; Gettner, P.; Sherwonit, E.; Williams, J.; Ehrenkranz, R. Morphine pharmacokinetics in premature newborns PediatrRes 1989 408
11. Barrett, D.A.; Elias-Jones, A.C.; Rutter, N.; Shaw, P.N.; Davis, S.S. Morphine kinetics after diamorphine infusion in premature neonates Brj Clin Pharmacol 1991 10.1111/j.1365-2125.1991.tb05609.x 32 31
12. Perlman, J.M.; Goodman, S.; Kreusser, K.L.; Volpe, J.J. Reduction in intraventricular hemorrhage by elimination of fluctuating cerebral blood-flow velocity in preterm infants with respiratory distress syndrome N EnglJfMed 1985 10.1056/NEJM198505233122104 312 1353
13. Hartley, R.; Green, M.; Quinn, M.; Levene, M.I. Analysis of morphine and its 3-and 6-glucuronides by high performance liquid chromatography with fluorometric detection following solid phase extraction from neonatal plasma Biomed Chromatogr 1993 10.1002/bmc.1130070109 7 34
14. Rowland, M.; Tozer, T.N. Clinical pharmacokinetics: concepts and applications 2nd Ed 1989
15. Sawe, J.; Svensson, J.O.; Rane, A. Morphine metabolism in cancer patients on increasing oral doses-no evidence for autoinduction or dose-dependence Br J Clin Pharmacol 1983 10.1111/j.1365-2125.1983.tb02148.x 16 85
16. Dahlstrom, B.; Boline, P.; Feychting, H.; Noack, G.; Paalzour, L. Morphine kinetics in children Clin Pharmacol Ther 1979 10.1002/cpt1979263354 26 354
17. Lynn, A.M.; Slattery, J.T. Morphine pharmacolinetics in early infancy Anesthesiology 1987 10.1097/00000542-198702000-00005 66 136
18. Marlow, N.; Weindling, A.M.; Cooke, R.W.I. Hazards of analgesia for newborn infants Arch Dis Child 1988 10.1136/adc.63.10.1293 63 1293
19. Koren, G.; Butt, W.; Chinyanga, H.; Soldin, S.; Tan, Y.K.; Pape, K. Postoperative morphine infusion in newborn infants: assessment of disposition characteristics and safety J Pediatr 1985 10.1016/S0022-3476(85)80205-5 107 963