Isocytosine H2-receptor histamine antagonists. IV. The synthesis and biological activity of donetidine (SK&F 93574) and related compounds

European Journal of Medicinal Chemistry

Volumn 28, Issue 7-8, 1993, Pages 601-608

  Brown, TH ^a   Blakemore, RC ^a   Durant, GJ ^a   Ganellin, CR ^a   Parsons, ME ^a   Rasmussen, AC ^a   Rawlings, DA ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

2 amino 4 pyrimidones (isocytosines); 2 guanidinothiazoles; donetidine (SK F 93574); furans; H2 receptor antagonists; imidazoles; pyridines; thiazoles

Indexed keywords

CIMETIDINE; DONETIDINE; HISTAMINE H2 RECEPTOR; ISOCYTOSINE DERIVATIVE; LUPITIDINE; PYRIMIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GUINEA PIG; HEART ATRIUM; HUMAN; HUMAN EXPERIMENT; ILEUM; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; NORMAL HUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE CONTRACTION; STOMACH ACID SECRETION; TACHYCARDIA;

EID: 0027223829     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/0223-5234(93)90091-R     Document Type: Article

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