Striatal degeneration induced by mitochondrial blockade is prevented by biologically delivered NGF

Journal of Neuroscience Research

Volumn 35, Issue 4, 1993, Pages 452-458

  Frim, D M ^a,b   Simpson, J ^a   Uhler, T A ^a   Short, M P ^c   Bossi, S R ^a   Breakefield, X O ^c,d,e   Isacson, O ^a,c,d,e  

^a MCLEAN HOSPITAL   (United States)

^b Molecular Neuro Oncology Laboratories   (United States)

^c Neurology Service   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e HARVARD MEDICAL SCHOOL   (United States)

Author keywords

3 nitropropionic acid; genetically engineered cells; neural transplantation; neuroprotection

Indexed keywords

3 NITROPROPIONIC ACID; GLUTAMATE RECEPTOR; NERVE GROWTH FACTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL ENERGY; CELL PROTECTION; CORPUS STRIATUM; FIBROBLAST CULTURE; HUNTINGTON CHOREA; MALE; MITOCHONDRIAL RESPIRATION; NERVE DEGENERATION; NERVE TRANSPLANTATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ACETYLCHOLINESTERASE; ANIMAL; BRAIN TISSUE TRANSPLANTATION; CELL LINE; CORPUS STRIATUM; ENERGY METABOLISM; FIBROBLASTS; GENETIC ENGINEERING; IMMUNOHISTOCHEMISTRY; MALE; MITOCHONDRIA; NERVE DEGENERATION; NERVE GROWTH FACTORS; NEUROTOXINS; PROPIONIC ACIDS; RATS; RATS, SPRAGUE-DAWLEY; SUPPORT, U.S. GOV'T, P.H.S.; TYROSINE 3-MONOOXYGENASE;

EID: 0027221981     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.490350413     Document Type: Article

References (50)

1. What, if anything, is a neurotrophic factor?
2. Does impairment of energy metabolism result in excitotoxic neuronaldeath in neurodegenerative illnesses?
3. Nucleotide sequence and exact location of the neomycin phosphotransferase gene from transposon Tn5
4. The MPTP model: Versatile contributions to the treatment of idiopathic Parkinson's disease
5. Age dependence of striatal neuronal death caused by mitochondrial dysfunction
6. Combining CNS transplantation and gene transfer
7. Herpes simplex virus for gene delivery to neurons
8. Regional mitochondrial respiratory activity in Huntington's disease brain
9. Neuropathological changes in Huntington's chorea
10. Glutamate neurotoxicity and diseases of the nervous system
11. The role of glutamate neurotoxicity in hypoxic‐ischemic neuronal death
12. The emerging generality of the neurotrophic hypothesis
13. Local response to intracerebral grafts of NGF‐secreting fibroblasts: Induction of a peroxidative enzyme
14. Nerve growth factor‐secreting fibroblasts protect only locally against excitotoxic lesions in the rat striatum
15. MPTP‐induced neurotoxicity and the quest for a preventive therapy for Parkinson's disease
16. Gene therapy in the CNS: Intracerebral grafting ofgenetically modified cells
17. Distribution of acetylcholinesterase in the hippocampal region of the guinea pig
18. Evolutionary studies of the nerve growth factor family reveal a novel member abundantly expressed in Xenopus ovary
19. Nature and distribution of brain lesions in rats intoxicated with 3‐nitropropionic acid: A type of hypoxic (energy deficient) brain damage
20. Nerve growth factor promotes survival of septal cholinergic neurons after fimbrial transections
21. Identification and characterization of a novel member of the nerve growth factor/brain derived growth factor family
22. Role of nerve growth factor in oxidant‐antioxidant balance and neuronal injury. I. Stimulation of hydrogen peroxide resistance
23. A calcium set‐point hypothesis of neuronal dependence on neurotrophic factors
24. Massive increases in extracellular potassium and the indiscriminaterelease of glutamate following concussive brain injury
25. Calcium induced neuronal degeneration: A normal growth cone regulating signal gone awry?
26. The histochemical localization ofcholinesterases in the central nervous system of the rat
27. Molecular cloning and expression of brain derived neurotrophic factor
28. 3‐Nitropropionic acid: Abundant xenobiotic excitotoxin linked to putaminal necrosis and tardive dystonia
29. Neurotrophin‐3: A neurotrophic factor related to NGF and BDNF
30. Ghtamate dysfunction in Alzheimer's disease: An hypothesis
31. Excitatory amino acids, growth factors, and calcium: A teeter‐totter model for neural plasticity and degeneration
32. Considerations in the treatment of neurological disorders with trophic factors
33. Remodelling of early axonal projections through the selective elimination ofneurons and long axonal collaterals
34. Evidence for a defect in NADH: Ubiquinone oxireductase (complex I) in Huntington's disease
35. Heat shock protein protects cultured neurons from glutamate toicity
36. Grafting genetically modified cells to the damaged brain: Restorative effects of NGF expression
37. The neurotoxicity of excitatory amino acids is produced by passive chloride influx
38. Intracerebral implantation of nerve growth factor‐producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids
39. + pump necessary for NGF mediated neuronal survival?
40. Mechanism of neurotoxicity of MPTP
41. + pump may mediate the control of nerve cells by nerve growth factor
42. Neurotrophic molecules
43. Neurotrophic factors
44. + neurotoxicity by N‐methyl‐D‐aspartate antagonists
45. Nerve growth factor infusion into the primate brain reduces lesion‐induced cholinergic neuronal degeneration
46. Neuropathological classification of Huntington's disease
47. Mitochondrial genetics: A paradigm for aging and degenerative diseases?
48. Mechanisms underlying initiation of excitotoxicity associated with metabolic inhibition