Peptidomimetic HIV Protease Inhibitors: Phosphate Prodrugs with Improved Biological Activities

Journal of Medicinal Chemistry

Volumn 36, Issue 17, 1993, Pages 2575-2577

  Chong, Kong Teck ^a   Ruwart, Mary J ^a   Hinshaw, Roger R ^a   Wilkinson, Karen F ^a   Rush, Bob D ^a   Yancey, Mark F ^a   Strohbach, Joseph W ^a   Thaisrivongs, Suvit ^a  

^a PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 (NAPHTHOXYACETYL)HISTIDYL(5 AMINO 6 CYCLOHEXYL 3,4 DIHYDROXY 2 ISOPROPYLHEXANOYL)ISOLEUCINE N (2 PYRIDYLMETHYL)AMIDE; AMINO ACID; ANTIGEN P24; N [6 CYCLOHEXYL 4 HYDROXY 2 ISOPROPYL 5 [(1 NAPHTHOXYACETYLHISTIDYL)AMINO]HEXANOYL]ISOLEUCINE N (2 PYRIDYLMETHYL)AMIDE; PRODRUG; PROTEINASE INHIBITOR; UNCLASSIFIED DRUG; VIRUS ENZYME;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG POTENCY; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMAL; ANTIVIRAL AGENTS; HALF-LIFE; HIV PROTEASE INHIBITORS; HUMAN; MALE; ORGANOPHOSPHORUS COMPOUNDS; PRODRUGS; RATS; RATS, SPRAGUE-DAWLEY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0027220895     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm00069a018     Document Type: Editorial

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