The effects of 6-hydroxydopamine lesions of the nucleus accumbens and the mesolimbic dopamine system on oral self-administration of ethanol in the rat

Brain Research

Volumn 623, Issue 1, 1993, Pages 16-24

  Rassnick, Stefanie ^a   Stinus, Luis ^b   Koob, George F ^a  

^a SCRIPPS RESEARCH INSTITUTE   (United States)

^b INSERM   (France)

Author keywords

6 Hydroxydopamine; Dopamine; Ethanol self administration; Mesolimbic; Nucleus Accumbens; Reinforcement

Indexed keywords

ALCOHOL; OXIDOPAMINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; CONTROLLED STUDY; DOPAMINE BRAIN LEVEL; DOPAMINERGIC SYSTEM; MALE; NONHUMAN; NUCLEUS ACCUMBENS; PRIORITY JOURNAL; RAT; REINFORCEMENT; SELF MEDICATION;

ADMINISTRATION, ORAL; ALCOHOL DRINKING; AMYGDALA; ANALYSIS OF VARIANCE; ANIMAL; BODY WEIGHT; CORPUS STRIATUM; DOPAMINE; FRONTAL LOBE; LIMBIC SYSTEM; MALE; MOTOR ACTIVITY; NUCLEUS ACCUMBENS; OLFACTORY BULB; OXIDOPAMINE; RATS; RATS, WISTAR; REFERENCE VALUES; SELF ADMINISTRATION; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027220050     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/0006-8993(93)90004-7     Document Type: Article

References (46)

1. Compensatory increase in tyrosine hydroxylase activity in rat brain after intraventricular injections of 6-hydroxydopamine
2. Dopamine and anticipatory behavior. I. Effects of pimozide
3. The effects of selective catecholamine depletions by 6-hydroxydopamine on ethanol preference in rats
4. Lack of effect of dopamine receptor blockade on voluntary ethanol consumption in rats
5. Limbic-striatal interactions in reward related processes: modulation by the dopaminergic system
6. Nigrostriatal lesions enhance striatal 3H-apomorphine and 3H-spiroperidol binding
7. Spontaneous ingestion of ethanol on brain dopamine metabolism
8. Determination of catecholamines in rat brain parts by reverse-phase ion-pair liquid chromatography
9. Possible substrates of ethanol reinforcement: GABA and dopamine
10. Opioidergic, serotonergic and dopaminergic manipulations and rats' intake of sweetened alcoholic beverage
11. Increased number of GABAergic terminals in the nucleus accumbens is associated with alcohol preference in rats
12. Preferential stimulation of dopamine release in the nucleus accumbens of freely moving rats by ethanol
13. Amphetamine-, scopolamine- and caffeine-induced locomotor activity following 6-hydroxydopamine lesions of the mesolimbic dopamine system
14. Amphetamine and apomorphine responses in the rat following 6-OHDA lesions of the nucleus accumbens septi and corpus striatum
15. Dopamine addiction and reward
16. Effects of 6-hydroxydopamine lesions of the nucleus accumbens septi and olfactory tubercle on feeding, locomotor activity and amphetamine anorexia in the rat
17. Neuroleptic-like disruption of the conditioned avoidance response requires destruction of both the mesolimbic and nigrostriatal dopamine systems
18. Effects of dopaminergic agents on alcohol consumption by rats in a limited access paradigm
19. Destruction of dopaminergic nerve terminals in nucleus accumbens: effect onD-amphetamine self-administration
20. Influence of dopaminergic and serotonergic neurons on intravenous ethanol self-administration in the rat
21. Effects of fluoxetine on the intragastric self-administration of ethanol in the alcohol preferring P lines of rats
22. Anatomical ‘circuitry’ in the brain mediating alcohol drinking revealed by THP reactive sites in the limbic system
23. Destruction of dopamine in the nucleus accumbens selectively attenuates cocaine but not heroin self-administration in rats
24. Haloperidol and apomorphine effects on ethanol reinforcement in free-feeding rats
25. GABA antagonist and benzodiazepine partial inverse agonist reduce motivated responding for ethanol
26. Oral ethanol self-administration in rats is reduced by the administration of dopamine and glutamate receptor antagonists into the nucleus accumbens
27. SDZ 205,152, a novel dopamine receptor agonist, reduces oral ethanol self-administration in rats
28. Initiation of ethanol reinforcement using a sucrose-substitution procedure in food- and water-sated rats
29. The role of the mesolimbic dopamine system in ethanol self-administration
30. Effect of dopamine agonists and antagonists on ethanol reinforced behavior: the involvement of the nucleus accumbens
31. Alcohol self-administration: role of mesolimbic dopamine
32. 5-HT and alcohol abuse
33. Increased dopamine efflux from striatal slices during development and after nigrostriatal bundle damage
34. Dopaminergic supersensitivity induced by denervation and chronic receptor blockade is additive
35. Postsynaptic supersensitivity after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system
36. Blockade of amphetamine but not opiate-induced locomotion following antagonism of dopamine function in the rat
37. Neurochemical correlates of cocaine and ethanol self-administration
38. Free-choice responding for ethanol versus water in alcohol-preferring (P) and unselected Wistar rats is differentially altered by naloxone, bromocriptine and methylsergide
39. Catecholamine theories of reward: a critical review
40. A preliminary study of PCP-like behavioral effects of 2-amino-5-phosphonovalerate in Rhesus monkeys
41. Focal application of alcohols elevate extracellular dopamine in rat brain: a microdialysis study
42. Alcohol stimulates the release of dopamine and serotonin in the nucleus accumbens
43. Supersensitivity after intraventricular 6-hydroxydopamine: relation to dopamine depletion