Restricted immunoglobulin VH usage and VDJ combinations in the human response to Haemophilus influenzae type b capsular polysaccharide: Nucleotide sequences of monospecific anti-Haemophilus antibodies and polyspecific antibodies cross-reacting with self antigens

Journal of Clinical Investigation

Volumn 91, Issue 6, 1993, Pages 2734-2743

  Adderson, Elisabeth E ^a   Shackelford, Penelope G ^b   Quinn, Anthony ^c   Wilson, Patricia M ^b   Cunningham, Madeleine W ^c   Insel, Richard A ^d   Carroll, William L ^a  

^a UNIVERSITY OF UTAH   (United States)

^b WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF OKLAHOMA   (United States)

^d UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

Author keywords

Antibody repertoire; Autoimmunity; Immunoglobulin heavy chain; Polysaccharide; Somatic mutation

Indexed keywords

AUTOANTIGEN; BACTERIUM ANTIBODY; CROSS REACTING ANTIBODY; DNA; IMMUNOGLOBULIN HEAVY CHAIN; POLYSACCHARIDE;

ADULT; ANTIGEN SPECIFICITY; ARTICLE; BACTERIAL INFECTION; BACTERIAL MEMBRANE; CHILD; DNA RESTRICTION; ENZYME LINKED IMMUNOSORBENT ASSAY; HAEMOPHILUS INFLUENZAE TYPE B; HUMAN; HYBRIDOMA; IMMUNE RESPONSE; NONHUMAN; NUCLEOTIDE SEQUENCE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; SOMATIC MUTATION;

AMINO ACID SEQUENCE; ANTIBODIES, BACTERIAL; AUTOANTIBODIES; BACTERIAL CAPSULES; BASE SEQUENCE; COMPARATIVE STUDY; GENE REARRANGEMENT, B-LYMPHOCYTE; GENES, IMMUNOGLOBULIN; HAEMOPHILUS INFLUENZAE; HUMAN; HYBRIDOMAS; IMMUNOGLOBULIN VARIABLE REGION; MOLECULAR SEQUENCE DATA; POLYSACCHARIDES, BACTERIAL; SEQUENCE ANALYSIS; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027216150     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI116514     Document Type: Article

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