Solution Conformation of the (+)-cis-anti-[BP]dG Adduct in a DNA Duplex: Intercalation of the Covalently Attached Benzo[a]pyrenyl Ring into the Helix and Displacement of the Modified Deoxyguanosine

Biochemistry

Volumn 32, Issue 16, 1993, Pages 4145-4155

  Cosman, Monique ^a,b   de los Santos, Carlos ^a,b   Fiala, Radovan ^a,b   Hingerty, Brian E ^c   Ibanez, Victor ^d   Luna, Ernestina ^e   Harvey, Ronald ^e   Geacintov, Nicholas E ^d   Broyde, Suse ^e   Patel, Dinshaw J ^a,b  

^a Columbia University ^*  (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c OAK RIDGE NATIONAL LABORATORY   (United States)

^d UNIVERSITY OF CHICAGO   (United States)

^e NEW YORK UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZO[A]PYRENE; DEOXYGUANOSINE;

ARTICLE; CONFORMATIONAL TRANSITION; COVALENT BOND; DNA ADDUCT; DNA CONFORMATION; DNA DAMAGE; DNA HELIX; EQUILIBRIUM CONSTANT; INTERCALATION COMPLEX; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; BASE COMPOSITION; BASE SEQUENCE; BENZO(A)PYRENE; DEOXYGUANOSINE; DNA; HYDROGEN BONDING; INTERCALATING AGENTS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; OLIGODEOXYRIBONUCLEOTIDES; SOLUTIONS; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, NON-P.H.S.; SUPPORT, U.S. GOV'T, P.H.S.; THERMODYNAMICS;

EID: 0027215240     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi00067a001     Document Type: Article

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