Phospholipase C-γ1 and phosphatidylinositol 3 kinase are the downstream mediators of the PDGF receptor's mitogenic signal

Cell

Volumn 73, Issue 2, 1993, Pages 321-334

  Valius, Mindaugas ^a   Kazlauskas, Andrius ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; INOSITOL PHOSPHATE; PHOSPHATIDYLINOSITOL KINASE; PHOSPHOLIPASE C; PLATELET DERIVED GROWTH FACTOR; PLATELET DERIVED GROWTH FACTOR RECEPTOR; RAS PROTEIN;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DNA SYNTHESIS; ENZYME ACTIVITY; EPITHELIUM CELL; HEPATOMA CELL; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOREGULATION; MITOGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; DNA; DNA MUTATIONAL ANALYSIS; ENZYME ACTIVATION; GTPASE-ACTIVATING PROTEINS; HUMAN; IN VITRO; MITOSIS; PHOSPHOLIPASE C; PHOSPHOTRANSFERASES; PHOSPHOTYROSINE; PLATELET-DERIVED GROWTH FACTOR; PROTEIN-TYROSINE KINASE; PROTEINS; RAS GTPASE-ACTIVATING PROTEINS; RECEPTORS, PLATELET-DERIVED GROWTH FACTOR; SIGNAL TRANSDUCTION; SUPPORT, U.S. GOV'T, P.H.S.; TUMOR CELLS, CULTURED; TYROSINE;

ANIMALIA;

EID: 0027211693     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(93)90232-F     Document Type: Article

References (68)

1. PDGF-dependent tyrosine phosphorylation stimulates production of novel polyphosphoinositides in intact cells
2. Phosphatidylinositol 3-kinase and its novel product, phosphatidylinositol 3-phosphate, are present in Saccharomyces cerevisiae
3. Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation
4. Cell death and control of cell survival in the oligodendrocyte lineage
5. Oncogenes and signal transduction
6. Purification and characterization of phosphoinositide e-kinase from rat liver
7. Role of phosphatidylinositol kinase in PDGF receptor signal transduction
8. Phosphoinositide 3-kinase: a new effector in signal transduction?
9. Mutations of the platelet-derived growth factor receptor that cause a loss of ligand-induced conformation change, subtle changes in kinase activity, and impaired ability to stimulate DNA synthesis
10. Distinct phosphotyrosines on a growth factor receptor bind to specific molecules that mediate different signalling pathways
11. Inhibition of neointimal smooth muscle accumulation after antioplasty by an antibody to PDGF
12. src protein
13. Expression of the normal human sis/PDGF-2 coding sequence induces cellular transformation
14. Modulation of guanine nucleotides bound to Ras in NIH 3T3 cells by oncogenes, growth factors, and the GTPase activating protein (GAP)
15. Regulation of phospholipase C-γ1 by profilin and tyrosine phosphorylation
16. Platelet-derived growth factor mechanism of action and possible in vivo function
17. Characterization of VPS34, a gene required for vacuolar protein sorting and vacuole segregation in Saccharomyces cerevisiae
18. Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit
19. PDGF-induced activation of phospholipase C is not required for induction of DNA synthesis
20. q protein induces malignant transformation in NIH 3T3 cells
21. PDGF β-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex
22. Phosphorylation sites at the C-terminus of the platelet-derived growth factor receptor bind phospholipase Cγ1
23. Phosphorylation sites in the PDGF receptor with different specificities for binding GAP and PI3 kinase in vivo
24. Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins
25. Binding of GAP to activated PDGF receptors
26. Functions of the major tyrosine phosphorylation site of the PDGF receptor β subunit
27. GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor β subunit
28. PDGF stimulation of inositol phospholipid hydrolysis requires PLC-γ1 phosphorylation on tyrosine residues 783 and 1254
29. SH2 and SH3 domains: elements that control interactions of cytoplasmic signaling proteins
30. Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C
31. Association between the PDGF receptor and members of the src family of tyrosine kinases
32. The SH2 and SH3 domain-containing Nck protein is oncogenic and a common target for phosphorylation by different surface receptors
33. Transformation-defective mutants of polyomavirus middle T antigen associate with phosphotidylinositol 3-kinase (PI 3-kinase) but are unable to maintain wild-type levels of PI 3-kinase products in intact cells
34. Phosphatidylinositol 3-phosphate is present in normal and transformed fibroblasts and is resistant to hydrolysis by bovine brain phospholipase C II
35. The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling
36. Improved retroviral vectors for gene transfer and expression
37. Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF β-receptor
38. ras GTPase-activating protein
39. Platelet-derived growth factor (PDGF)-dependent association of phospholipase C-γ with the PDGF receptor signaling complex
40. A PDGF receptor mutation in the mouse (Patch) perturbs the development of a non-neuronal subset of neural crest-derived cells
41. Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 cells
42. IRS-1 activates phosphatidylinositol 3′-kinase by associating with src homology 2 domains of p85
43. Activation of the ζ isoenzyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate
44. Increase of the catalytic activity of phospholipse C-γ1 by tyrosine phosphorylation
45. Studies and perspectives of protein kinase C
46. Intracellular signaling by hydrolysis of phospholipids and activation of protein kinase C
47. Activation of phosphatidylinositol-3 kinase by nerve growth factor involves indirect coupling of the trk proto-oncogene with src homology 2 domains
48. Phosphatidylinositol 3-kinase: a novel effector
49. Oncogenic forms of the neu/HER2 tyrosine kinase are permanently coupled to phospholipase Cγ
50. Studies of inositol phospholipid-specific phospholipase C
51. Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases
52. Identification of two C-terminal autophosphorylation sites in the PDGF β-receptor: involvement in the interaction with phospholipase C-γ
53. ras GTP complex in Swiss mouse 3T3 cells
54. Function of ras as a molecular switch in signal transduction
55. Two different subunits associate to create isoform-specific platelet-derived growth factor receptors
56. Binding of the H-ras p21 GTPase activating protein by the activated epidermal growth factor receptor leads to inhibition of the p21 GTPase activity in vitro
57. Polyphosphoinositides produced by phosphatidylinositol 3-kinase are poor substrate for phospholipases C from rat liver and bovine brain
58. Production of novel polyphosphoinositides in vivo is linked to cell transformation by polymavirus middle T antigen
59. Molecular cloning of cDNAs encoding the RasGAP-associated protein p190: implications for a signaling pathway from ras to the nucleus
60. ras with phosphatidylinositol 3-kinase
61. Platelet-derived growth factor receptor α-subunit gene (Pdgfra) is deleted in the mouse patch (Ph) mutation
62. q class of G proteins
63. Tyrosines 1021 and 1009 are phosphorylation sites in the carboxy terminus of the platelet-derived growth factor receptor β subunit and are required for binding of phospholipase Cγ and a 64-kilodalton protein, respectively
64. Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-γ in quiescent BALB/c 3T3 cells
65. Type I phosphatidylinositol kinase makes a novel inositol phospholipid, phosphatidylinositol-3-phosphate
66. Signal transduction by the platelet-derived growth factor receptor
67. Molecular cloning and nucleic acid biding properties of the GAP-associated tyrosine phosphoprotein p62
68. Mechanistic aspects of signalling through Ras in NIH 3T3 cells