Ulcerative colitis: A genetically heterogeneous disorder defined by genetic (HLA class II) and subclinical (antineutrophil cytoplasmic antibodies) markers

Journal of Clinical Investigation

Volumn 92, Issue 2, 1993, Pages 1080-1084

  Yang, Huiying ^a,b   Rotter, Jerome I ^a   Toyoda, Hiroo ^a   Landers, Carol ^a   Tyan, Dolly ^a   McElree, Colleen K ^a   Targan, Stephan R ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b CEDARS SINAI MEDICAL CENTER   (United States)

Author keywords

Antibodies; HLA association; Inflammatory bowel disease

Indexed keywords

BIOLOGICAL MARKER; HLA ANTIGEN CLASS 2;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CROHN DISEASE; DISEASE PREDISPOSITION; ENTERITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; GENETIC HETEROGENEITY; GENETIC MARKER; GENETIC PREDISPOSITION; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; ULCERATIVE COLITIS;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; AUTOANTIBODIES; BIOLOGICAL MARKERS; COLITIS, ULCERATIVE; COMPARATIVE STUDY; DNA; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; GENES, MHC CLASS I; GENES, MHC CLASS II; GENETIC MARKERS; HISTOCOMPATIBILITY TESTING; HLA-DQ ANTIGENS; HLA-DR ANTIGENS; HUMAN; LEUKOCYTES; MALE; MIDDLE AGE; NEUTROPHILS; REFERENCE VALUES; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027205545     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI116613     Document Type: Article

References (28)

1. Yang, H., T. Shohat, and J. I. Rotter. 1992. The genetics of inflammatory bowel disease. In Inflammatory Bowel Disease. R. P. MacDermott and W. F. Stenson, editors. Elsevier Science Publishing Co., Inc., New York. pp. 17-51.
2. Rotter, J. I., H. Yang, and T. Shohat. 1992. Genetic complexities of inflammatory bowel disease and its distribution among the Jewish people. In Genetic Diversity Among Jews: Diseases and Markers at the DNA Level. B. Bonne-Tamir and A. Adam, editors, Oxford University Press, New York. pp. 395-411.
3. Shanahan, F., R. H. Duerr, J. I. Rotter, H. Yang, L. R. Sutherland, C. McElree, C. J. Landers, and S. R. Targan. 1992. Neutrophil autoantibodies in ulcerative colitis: familial aggregation and genetic heterogeneity. Gastroenterology 103:456-461.
4. Toyoda, H., S.-J. Wang, H. Yang, A. Redford, D. Magalong, D. Tyan, C. McElree, S. Pressman, F. Shanahan, S. Targan, and J. I. Rotter. 1993. Distinct associations of HLA class II genes with inflammatory bowel disease. Gastroenterology. 104:741-748.
5. van der Woude, F. J., N. Rasmussen, S. Lobatto, A. Wiik, H. Permin, L. A. van Es, M. van der Giessen, and G. K. van der Hem. 1985. Autoantibodies against neutrophils and monocytes: tool for diagnosis and marker of disease activity in Wegener's granulomatosis. Lancet i:425-429.
6. Saxon, A., F. Shanahan, C. Landers, T. Ganz, and S. R. Targan. 1990. A distinct subset of antineutrophil cytoplasmic antibodies is associated with inflammatory bowel disease. J. Allergy Clin. Immunol. 86:202-210.
7. Duerr, R. H., S. R. Targan, C. J. Landers, L. R. Sutherland, and F. Shanahan. 1991. Anti-neutrophil cytoplasmic antibodies in ulcerative colitis. Comparison with other colitides/diarrheal illnesses. Gastroenterology 100:1590-1596.
8. Cambridge, G., D. S. Rampton, T. R. J. Stevens, D. A. McCarthy, M. Kamm, and B. Leaker. 1992. Anti-neutrophil antibodies in inflammatory bowel disease: prevalence and diagnostic role. Gut. 33:668-674.
9. Seibold, F., P. Weber, R. Klein, P. A. Berg, and K. H. Wiedmann. 1992. Clinical significance of antibodies against neutrophils in patients with inflammatory bowel disease and primary sclerosing cholangitis. Gut. 33:657-662.
10. Boyum, A. 1968. Separation of leukocytes from blood and bone marrow. Scand J Clin. Lab. Invest. 21:31-50.
11. Redford, A., D. Magalong, M. Onohara-Toyoda, D. Tyan, W. Riley, N. Maclaren, J. I. Rotter, and H. Toyoda. 1991. Restriction fragment length polymorphism (RFLP) heterogeneity of HLA-DQ beta genes associated with DNA fragment identical to the DR-I beta DNA structure. Dis. Markers. 9:257-263.
12. Toyoda, H. 1992. Application of synthetic oligonucleotide probes for gene analysis. Methods Enzymol. 216:108-115.
13. Southern, E. M. 1975. Detection of specific sequence among DNA fragments separated by gel electrophoresis. J Mol Biol. 98:503-517.
14. Feinberg, A. P., and B. Vogelstein. 1983. A technique for radiolabelling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem. 132:6-13.
15. Long, E. O., C. T. Wake, J. Gorski, and B. Mach. 1983. Complete sequence of an HLA-DR beta chain deduced from a cDNA clone and identification of multiple non-allelic DR beta chain genes. EMBO (Eur. Mol. Biol. Organ.) J. 2:389-394.
16. Larhammer, D. L., L. Schenning, K. Gustaffsson, K. Wiman, L. Claesson, L. Rask, and P. A. Peterson. 1982. Complete amino acid sequence of an HLA-DR antigen-like beta chain as predicted from the nucleotide sequence: Similarities with immunoglobulins and HLA-A, -B, and -C antigens. Proc. Natl. Acad. Sci. USA. 79:3687-3691.
17. Lizak, G. E., F. C. Grumet. 1980. A new micromethod for the in vitro detection of antiplatelet antibodies: C-FDA thrombocytotoxicity. Hum. Immunol. 1:87-96.
18. Snedecor, G. W., and W. G. Cochran. 1982. Statistical methods. The Iowa State University Press, Ames, IA. pp. 107-134.
19. Schlesselman, J. J. 1982. Case-Control Studies: Design, Conduct, Analysis. Oxford University Press, New York. pp. 183-190.
20. Neigut, D., R. Proujansky, M. Trucco, J. S. Dorman, S. Kocoshis, A. B. Carpenter, and E. J. Ball. 1992. Association of an HLA-DQB-I genotype with Crohn's disease in children. Gastroenterology. 102:A671. (Abstr.).
21. Reumaux, D., L. Delecourt, J. F. Colombel, P. Duthilleul, C. Gower-Rousseau, L. H. Nöel, and A. Cortot. 1992. Prevalence of antineutrophil cytoplasmic auto-antibodies (ANCA) in relatives of patients with ulcerative colitis (UC). Gastroenterology. 102:A683. (Abstr.).
22. Nepom, G. T., and H. Erlich. 1991. MHC class-II molecules and autoimmunity. Annu. Rev. Immunol. 9:493-525.
23. Snook, J. A., H. J. de Silva, and D. P. Jewell. 1989. The association of autoimmune disorders with inflammatory bowel disease. Q. J. Med (New Series) 72:835-840.
24. Tiwari, J. L., and P. I. Terasaki. 1985. HLA and Disease Associations. Springer-Verlag New York Inc., New York. pp. 32-48.
25. Sadovnick, A. D., D. W. Paty, G. Yannakoulias. 1989. Concurrence of multiple sclerosis and inflammatory bowel disease. N. Engl. J. Med. 321:762-763.
26. Rang, E. H., B. N. Brooke, J. Hermon-Taylor. 1982. Association of ulcerative colitis and multiple sclerosis. Lancet ii:555.
27. Roth, M. -P., G. M. Petersen, C. McElree, C. M. Vadheim, J. F. Panish, and J. I. Rotter. 1989. Familial recurrence risk estimates of inflammatory bowel disease in Ashkenazi Jews. Gastroenterology. 96:1016-1020.
28. Yang, H., C. McElree, M.-P. Roth, F. Shanahan, S. R. Targan, and J. I. Rotter 1992. Familial empiric risks for inflammatory bowel disease. Difference between Jews and non-Jews. Gut. In press.