"Diversomers": An approach to nonpeptide, nonoligomeric chemical diversity

Proceedings of the National Academy of Sciences of the United States of America

Volumn 90, Issue 15, 1993, Pages 6909-6913

  Dewitt, Sheila Hobbs ^a   Kiely, John S ^a,b   Stankovic, Charles J ^a   Schroeder, Mel C ^a   Cody, Donna M Reynolds ^a   Pavia, Michael R ^a,c  

^a PFIZER INC   (United States)

^b ISIS PHARMACEUTICALS   (United States)

^c Sphinx Pharmaceuticals   (United States)

Author keywords

Benzodiazepine; Hydantoin; Multiple synthesis; Solid phase synthesis

Indexed keywords

BENZODIAZEPINE; DIPEPTIDE; HYDANTOIN; OLIGOMER;

ARTICLE; BIOASSAY; ORGANIC CHEMISTRY; PRIORITY JOURNAL; SYNTHESIS;

ANIMAL; AUTOMATION; BENZODIAZEPINES; BINDING, COMPETITIVE; CATTLE; CHEMISTRY; DIPEPTIDES; HYDANTOINS; IN VITRO; NITRAZEPAM; RECEPTORS, GABA-A; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0027202613     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.90.15.6909     Document Type: Article

References (33)

1. Dower, W. J. & Fodor, S. P. A. (1991) Annu. Rep. Med. Chem. 26, 271-280.
2. Fodor, S. P. A., Read, J. L., Pirrung, M. C., Stryer, L., Lu, A. T. & Solas, D. (1991) Science 251, 767-773.
3. Jung, G. & Beck-Sickinger, A. G. (1992) Angew. Chem. Int. Ed. Engl. 31, 367-383.
4. Zuckermann, R. N., Kerr, J. M., Siani, M. A., Banville, S. C. & Santi, D. V. (1992) Proc. Natl. Acad. Sci. USA 89, 4505-4509.
5. Scott, J. K. & Smith, G. P. (1990) Science 249, 386-390.
6. Devlin, J. J., Panganiban, L. C. & Devlin, P. E. (1990) Science 249, 404-406.
7. Cwirla, S. E., Peters, E. A., Barrett, R. W. & Dower, W. J. (1990) Proc. Natl. Acad. Sci. USA 87, 6378-6382.
8. Simon, R. J., Kania, R. S., Zuckermann, R. N., Huebner, V. D., Jewell, D. A., Banville, S., Ng, S., Wang, L., Rosenberg, S., Marlowe, C. K., Spellmeyer, D. C., Tan, R., Frankel, A. D., Santi, D. V., Cohen, F. E. & Bartlett, P. A. (1992) Proc. Natl. Acad. Sci. USA 89, 9367-9371.
9. Bunin, B. A. & Ellman, J. A. (1992) J. Am. Chem. Soc. 114, 10997-10998.
10. Gausepohl, H., Kraft, M., Boulin, C. & Frank, R. W. (1990) in Peptides: Chemistry, Structure, and Biology, Proceedings of the 11th American Peptide Symposium, eds. Rivier, J. & Marshall, G. (ESCOM, Leiden, The Netherlands), pp. 1003-1004.
11. Schnorrenberg, G. & Gerhardt, H. (1989) Tetrahedron 45, 6031-6040.
12. Geyson, H. M., Meloen, R. H. & Barteling, S. J. (1984) Proc. Natl. Acad. Sci. USA 82, 5131-5135.
13. Wang, S.-S. (1973) J. Am. Chem. Soc. 95, 1328-1333.
14. Leznoff, C. C. (1978) Acc. Chem. Res. 11, 327-333.
15. Crowley, J. I. & Rapoport, H. (1976) Acc. Chem. Res. 9, 135-144.
16. Leznoff, C. C. (1974) Chem. Soc. Rev. 3, 65-85.
17. Larsen, B. D., Holm, A., Christensen, D. H., Werner, F. & Nielsen, O. F. (1992) in Innovation and Perspectives in Solid Phase Synthesis, ed. Epton, R. (Intercept, Andover, U.K.), pp. 363-366.
18. Kauppinen, J. K., Moffatt, D. J., Mantsch, H. H. & Cameron, D. G. (1981) Anal. Chem. 53, 1454-1457.
19. Byler, D. M. & Susi, H. (1986) Biopolymer 25, 469-487.
20. Mapelli, C. & Swerdloff, M. D. (1990) in Peptides, eds. Giralt, E. & Andreu, D. (ESCOM, Leiden, The Netherlands), pp. 316-319.
21. Epton, R., Goddard, P. & Ivin, K. J. (1980) Polymer 21, 1367-1371.
22. Giralt, E., Rizo, J. & Pedroso, E. (1984) Tetrahedron 40, 4141-4152.
23. Merrifield, R. B. (1963) J. Am. Chem. Soc. 85, 2149-2154.
24. Bayer, E. (1991) Angew. Chem. Int. Ed. Engl. 32, 113-129.
25. Stewart, J. M. & Young, J. D., eds. (1984) Solid Phase Peptide Synthesis (Pierce Chemical, Rockford, IL).
26. Atherton, E., Gait, E. J., Sheppard, R. C. & Williams, B. J. (1979) Bioorg. Chem. 8, 351-370.
27. Camps, F., Cartells, J. & Pi, J. (1974) An. Quim. 70, 848-849.
28. Schmitt, J., Suquet, M., Boitard, J., Comoy, P., Meingan, J. P., Gallet, G., Clim, T., Perrin, C. & LeMeur, J. (1967) Ind. Chim. Belge. 32, 184-187.
29. O'Donnell, M. J. & Polt, R. L. (1982) J. Org. Chem. 47, 2663-2666.
30. Meguro, K. & Kuwada, Y. (1972) U.S. Patent 3,587,941.
31. Sternbach, L. H. & Richen, G. S. (1967) U.S. Patent 3,297,755.
32. Sugasawa, T., Adachi, M., Sasakura, K., Matsushita, A., Eigyo, M., Shiomi, T., Shintaku, H., Takahara, Y. & Murata, S. (1985) J. Med. Chem. 28, 699-707.
33. Sternbach, L. H., Randall, L. O., Banziger, R. & Lehr, H. (1968) in Drugs Affecting the Central Nervous System, ed. Burger, A. (Dekker, New York), pp. 237-264.