4,5,6,7-Tetrahdryo-8-oxo-cycloheptimidazoles: a new class of potent non-peptide angiiotensin II receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 3, Issue 8, 1993, Pages 1559-1564

  Yanagisawa, Takashi ^a   Ueyama, Naoto ^a   Kawai, Tomoyuki ^a   Sonegawa, Motoharu ^a   Baba, Hiromi ^a   Mochizuki, Seiichiro ^a   Kozakai, Kazukiro ^a   Tomiyama, Tsuyoshi ^a  

^a Kotobuki Seiyaku Co Ltd   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

4,5,6,7 TETRAHYDRO 8 OXO 2 PROPYL 1 [[2' (1H TETRAZOL 5 YL)BIPHENYL 4 YL]METHYL]CYCLOHEPTIMIDAZOLE; ANGIOTENSIN ANTAGONIST; ANGIOTENSIN II ANTAGONIST; ANGIOTENSIN RECEPTOR; CYCLOHEPTIMIDAZOLE DERIVATIVE; IMIDAZOLE DERIVATIVE; LOSARTAN; LOSARTAN POTASSIUM; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; HYPERTENSION; LIVER; ORAL DRUG ADMINISTRATION; RABBIT; RAT; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; STRUCTURE ACTIVITY RELATION; VASOCONSTRICTION;

EID: 0027202115     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)80018-9     Document Type: Article

References (23)

1. The discovery of DuP 753, a potent, orally active nonpeptide angiotensin II receptor antagonist
2. 1-(Carboxybenzyl)imidazole-5-acrylic acids: potent and selective angiotensin II receptor antagonists
3. Perfluorocarbon-based antidiabetic agents
4. Characterization of Binding Sites for the Angiotensin II Antagonist125I-[Sarc1,Ile8]-Angiotensin II on Murine Neuroblastoma N1E-115 Cells