Unveiling the mysteries of inherited disorders of bilirubin glucuronidation

Gastroenterology

Volumn 105, Issue 1, 1993, Pages 288-293

  Roy Chowdury, Jayanta ^a   Roy Chowdury, Namita ^a  

^a MARION BESSIN LIVER RESEARCH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; COMPLEMENTARY DNA; GLUCURONOSYLTRANSFERASE; MEMBRANE LIPID; MESSENGER RNA;

ALCOHOL LIVER DISEASE; BILIRUBIN BINDING; CRIGLER NAJJAR SYNDROME; EDITORIAL; ENZYME ACTIVITY; ENZYME DEFICIENCY; GILBERT DISEASE; GLUCURONIDATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; SURVIVAL;

BILIRUBIN; CRIGLER-NAJJAR SYNDROME; GILBERT DISEASE; GLUCURONATES; GLUCURONOSYLTRANSFERASE; HUMAN; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.;

EID: 0027200576     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1016/0016-5085(93)90041-A     Document Type: Editorial

References (50)

1. Studies on bilirubin kinetics in normal adults
2. Disorders of bilirubin conjugation
3. Reverse-phase HPLC separation, quantification and preparation of bilirubin and its conjugates from native bile
4. Constitutional nonhemolytic hyperbilirubinemia in the rat: defect of bilirubin conjugation
5. Gunn rat: An animal model for deficiency of bilirubin conjugation
6. Congenital defects in bilirubin metabolism (abstr)
7. Congenital familial non-hemolytic jaundice with kernicterus
8. Cloning of cDNAs coding for rat hepatic microsomal UDP-glucurono syltransferases
9. Rat liver UDP-glucuronosyltransferase: cDNA sequence and expression of a form glucuronidating 3-hydroxy androgens
10. Isolation and sequencing of rat liver bilirubin-UDP-glucuronosyltransferase cDNA: possible alternate splicing of a common primary transcript
11. Cloning and characterization of cDNA encoding 3-methylcholanthrene inducible rat messenger RNA for UDP-glucuronosyltransferase
12. The full length coding sequence of rat liver androsterone UDP-glucuronosyltransferase cDNA and comparison with other members of this gene family
13. Cloning ans substrate-specificity of a human phenol-UDP-glucuronosyl-transferase expressed in COS-7 cells
14. Cloning of two human liver bilirubin-UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells
15. Cloning and stable expression of a new member of a human liver phenol/bilirubin UDP-glucuronosyltransferase cDNA family
16. A novel complex locus UGT1 encodes human bilirubin, phenol and other UDP-glucuronosyltransferase isozymes with identical carboxy termini
17. A mutation in bilirubin undine 5′-diphosphate-glucuronosyltransferase isoform 1 causing Crigler-Najjar syndrome type I
18. Newer aspects of glucuronidation
19. Isolation and characterization of multiple forms of rat liver UDP-glucuronate glucuronosyltransferase
20. Isolation and characterization of a new rat bilirubin-UDP-glucuronosyltransferase that also mediates the glucuronidation of morphine (abstr)
21. Substrates and products of purified rat liver bilirubin-UDP-glucuronosyltransferase
22. Distribution of uridine diphosphoglucuronate glucuronosyl transferase in rat tissues
23. The influence of charge and the distribution of charge in the polar region of phospholipids on the activity of UDP-glucuronosyltransferase
24. A membrane transporter mediates access of uridine-5′-diphosphoglucuronic acid from the cytosol into the endoplasmic reticulum of rat hepatocytes. Implications for glucuronidation reactions
25. Comparison of compartmented and of conformational phospholipid-constraint models for the intramembranous arrangement of UDP-glucuronyltransferase
26. Studies on UDP glucuronyl transferase
27. Application of 5-azido-UDP-glucose and 5-azido-UDP-glucuronic acid photoaffinity probes for the determination of the active site orientation of microsomal UDP-glucosyltransferases and UDP-glucuronosyltransferases
28. Expression of chimeric cDNAs in cell culture defines a region of UDP-glucuronosyltransferase involved in substrate seletion
29. The UDP-glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence
30. Odorant signal termination by olfactory UDP glucuronosyl transferase
31. The novel bilirubin/phenol UDP-glucurono-syltransferase UGT1 gene locus: implications for multiple nonhemolytic familial hyperbilirubinemia phenotypes
32. As Assignment of the human UDP-glucuronosyltransferase gene UGT1A1 to chromosome 2 region 2q37
33. Functional heterogengeneity of UDP glucuronosyl transferase as indicated by its differential development and inducibility by glucocorticoids
34. Effects of phenobarbital and 3-methylcholanthrene on substrate specificity of rat liver microsomal UDP-glucuronyltransferase
35. Expression of specific UDP-glucuronosyltransferase isoforms in carcinogen-induced preneoplastic rat liver nodules
36. Crigler-Najjar syndrome (Type I) in an adult male
37. Sequence of exons and the flanking regions of human bilirubin-UDP-glucuronosyl-transferase gene complex and identification of a genetic mutation in a patient with Crigler-Najjar syndrome, Type I
38. Mechanism of inherited deficiencies of multiple UDP-glucuronosyltransferase isoforms in two patients with Crigler-Najjar syndrome, type I
39. Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar syndrome, Type I
40. Immunochemical analysis of uridine diphosphate-glucuronosyltransferase in four patients with the Crigler-Najjar syndrome Type I
41. Hereditary acholuric jaundice in a new mutant strain of rats
42. Induction of UDP-glucuronosyltransferase activities in Gunn, heterozygous, and Wistar rat livers by pregnenolone-16α-carbonitrile
43. Molecular basis for the lack of bilirubin-specific and 3-methylcholanthrene-inducible UDP-glucuronosyltransferase ac ac activities in Gunn rats The two isoforms are encoded by distinct mRNA species that share an identical single base deletion
44. Mechanism of the lack of induction of UDP-glucuronosyltransferase activity by 3-methylcholanthrene in Gunn rats
45. Chronic nonhemolytic unconjugated hyperbilirubinemia with glucuronyl transferase deficiency: clinical, biochemical, pharmacologie, and genetic evidence for heterogeneity
46. Unconjugated bilirubin and an increased proportion of bilirubin monoconjugates in the bile of patients with Gilbert's syndrome and Crigler-Najjar syndrome
47. Inheritance of type II Crigler-Najjar hyperbilirubinemia
48. La cholamae simple familiale
49. Idiopathic unconjugated hyperbilirubinemia (Gilbert's syndrome): A study of 42 families
50. Constitutional hepatic dysfunction (Gilbert's syndrome): A new definition based on kinetic studies with unconjugated radiobilirubin